Review of Human Herpes Viruses in Burns
Human Herpes Viruses in Burn Victims: A Systematic Review
1 other identifier
observational
10,267
0 countries
N/A
Brief Summary
Herpes simplex virus, cytomegalovirus and varicella zoster virus infection are purported to play a pivotal role in morbidity and mortality in burns. Thus far, there is no existing systematic review (Level of Evidence III or higher) describing the unique role as well as concurrent infections of these viruses in burns. The aim of this review is to point out the clinical differences between these human herpes virus subtypes, to outline established therapy approaches, and to provide evidence for virus related morbidity and mortality in burns.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2015
CompletedFirst Submitted
Initial submission to the registry
May 14, 2015
CompletedFirst Posted
Study publicly available on registry
May 22, 2015
CompletedMay 22, 2015
May 1, 2015
2 months
May 14, 2015
May 19, 2015
Conditions
Outcome Measures
Primary Outcomes (1)
Prevalence of Human Herpes Virus (HHV) Infections
HHV include the herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr viruses (EBV) and human herpes virus 6 to 8
Participants will be followed for the duration of hospital stay, an expected average of 3 months.
Secondary Outcomes (1)
Treatment of Human Herpes Virus (HHV) Infections
Participants will be followed for the duration of hospital stay, an expected average of 3 months.
Study Arms (1)
Burn patients
The included patient are burn victims who sustained a burn of at least 1 % total body surface are (TBSA); with no restriction on age.
Interventions
Review of the Medline database (PubMed and Ovid interface) for human herpes virus infections in burns as well as Web of Science interface. PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist were used.
Eligibility Criteria
Every year, about 500,000 citizens of the United States of America were burned; 50,000 of them were admitted to Burn Center. Bacterial and viral infections including cellulitis, pneumonia, wound infections and septicemia are among the top ten complications of burn injuries. Severe burn injury causes an increased inflammatory response and an overall immunosuppression. As a result severely burned patients are more prone to infections and septicemia. Early treatment of sepsis and prevention of infections are key to reducing morbidity and improving the long-term outcome of burn victims.
You may qualify if:
- Patients who presented with at least 1% TBSA burned
- Patients who presented with a viral infections during their hospitalization
You may not qualify if:
- Patients who had no burns
- Patients who had no viral infections during their hospitalization
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010;8(5):336-41. doi: 10.1016/j.ijsu.2010.02.007. Epub 2010 Feb 18. No abstract available.
PMID: 20171303BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
David N Herndon, MD, FACS
Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas, USA
Study Design
- Study Type
- observational
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 14, 2015
First Posted
May 22, 2015
Study Start
March 1, 2015
Primary Completion
May 1, 2015
Last Updated
May 22, 2015
Record last verified: 2015-05