Predictors of Airway Extubation/Weaning Failure

NCT02450669 | Completed

• 2 other identifiers: 9242ID-RCB
• Study Type: observational
• Target: 417
• Locations: 1 country
• Sites: 1

Brief Summary

Airway management in intensive care unit (ICU) patients is challenging. Benefit risk ratio of extubation has to be daily assessed in intubated patients. The investigators aimed to assess incidence and risk factors of airway failure after extubation procedure in critically ill patients in a prospective multicenter study.

Conditions

Intubation in Intensive Care Units

Keywords

Intubation; Extubation; Weaning; Mechanical ventilation

Outcome Measures

Primary Outcomes (1)

• Risk factors of airway failure (logistic regression will be used to identify risk factors)

  48 hours

Secondary Outcomes (1)

• Risf factors of extubation failure and weaning failure (Quantitative variables will be expressed as means (standard deviation) or medians (interquartiles 25%-75%) and compared using the student t test or the Wilcoxon test as appropriate

  48 hours

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All the adult patients extubated in the ICU

You may qualify if:

• Adult patient extubated in the ICU

You may not qualify if:

• Decision not to reintubate

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

CHU Montpellier

Montpellier, 34090, France

Location

Related Publications (18)

• Marini JJ, Smith TC, Lamb VJ. External work output and force generation during synchronized intermittent mechanical ventilation. Effect of machine assistance on breathing effort. Am Rev Respir Dis. 1988 Nov;138(5):1169-79. doi: 10.1164/ajrccm/138.5.1169.

  PMID: 3202477 RESULT

• Moschietto S, Doyen D, Grech L, Dellamonica J, Hyvernat H, Bernardin G. Transthoracic Echocardiography with Doppler Tissue Imaging predicts weaning failure from mechanical ventilation: evolution of the left ventricle relaxation rate during a spontaneous breathing trial is the key factor in weaning outcome. Crit Care. 2012 May 14;16(3):R81. doi: 10.1186/cc11339.

  PMID: 22583512 RESULT

• Montgomery AB, Holle RH, Neagley SR, Pierson DJ, Schoene RB. Prediction of successful ventilator weaning using airway occlusion pressure and hypercapnic challenge. Chest. 1987 Apr;91(4):496-9. doi: 10.1378/chest.91.4.496.

  PMID: 3829740 RESULT

• Epstein SK, Ciubotaru RL. Independent effects of etiology of failure and time to reintubation on outcome for patients failing extubation. Am J Respir Crit Care Med. 1998 Aug;158(2):489-93. doi: 10.1164/ajrccm.158.2.9711045.

  PMID: 9700126 RESULT

• Witt NJ, Zochodne DW, Bolton CF, Grand'Maison F, Wells G, Young GB, Sibbald WJ. Peripheral nerve function in sepsis and multiple organ failure. Chest. 1991 Jan;99(1):176-84. doi: 10.1378/chest.99.1.176.

  PMID: 1845860 RESULT

• Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE Jr, Inouye SK, Bernard GR, Dittus RS. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004 Apr 14;291(14):1753-62. doi: 10.1001/jama.291.14.1753.

  PMID: 15082703 RESULT

• Annane D, Sebille V, Charpentier C, Bollaert PE, Francois B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troche G, Chaumet-Riffaud P, Bellissant E. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA. 2002 Aug 21;288(7):862-71. doi: 10.1001/jama.288.7.862.

  PMID: 12186604 RESULT

• Boles JM, Bion J, Connors A, Herridge M, Marsh B, Melot C, Pearl R, Silverman H, Stanchina M, Vieillard-Baron A, Welte T. Weaning from mechanical ventilation. Eur Respir J. 2007 May;29(5):1033-56. doi: 10.1183/09031936.00010206.

  PMID: 17470624 RESULT

• Epstein SK, Ciubotaru RL, Wong JB. Effect of failed extubation on the outcome of mechanical ventilation. Chest. 1997 Jul;112(1):186-92. doi: 10.1378/chest.112.1.186.

  PMID: 9228375 RESULT

• Rothaar RC, Epstein SK. Extubation failure: magnitude of the problem, impact on outcomes, and prevention. Curr Opin Crit Care. 2003 Feb;9(1):59-66. doi: 10.1097/00075198-200302000-00011.

  PMID: 12548031 RESULT

• Francon D, Jaber S, Pean D, Bally B, Marciniak B. [Difficult extubation: extubation criteria and management of risk situations: question 6. Societe Francaise d'Anesthesie et de Reanimation]. Ann Fr Anesth Reanim. 2008 Jan;27(1):46-53. doi: 10.1016/j.annfar.2007.10.026. Epub 2007 Dec 31. No abstract available. French.

  PMID: 18164897 RESULT

• Jaber S, Chanques G, Matecki S, Ramonatxo M, Vergne C, Souche B, Perrigault PF, Eledjam JJ. Post-extubation stridor in intensive care unit patients. Risk factors evaluation and importance of the cuff-leak test. Intensive Care Med. 2003 Jan;29(1):69-74. doi: 10.1007/s00134-002-1563-4. Epub 2002 Nov 22.

  PMID: 12528025 RESULT

• Tanaka A, Isono S, Ishikawa T, Nishino T. Laryngeal reflex before and after placement of airway interventions: endotracheal tube and laryngeal mask airway. Anesthesiology. 2005 Jan;102(1):20-5. doi: 10.1097/00000542-200501000-00007.

  PMID: 15618782 RESULT

• Jaber S, Jung B, Matecki S, Petrof BJ. Clinical review: ventilator-induced diaphragmatic dysfunction--human studies confirm animal model findings! Crit Care. 2011 Mar 11;15(2):206. doi: 10.1186/cc10023.

  PMID: 21457528 RESULT

• Jaber S, Petrof BJ, Jung B, Chanques G, Berthet JP, Rabuel C, Bouyabrine H, Courouble P, Koechlin-Ramonatxo C, Sebbane M, Similowski T, Scheuermann V, Mebazaa A, Capdevila X, Mornet D, Mercier J, Lacampagne A, Philips A, Matecki S. Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans. Am J Respir Crit Care Med. 2011 Feb 1;183(3):364-71. doi: 10.1164/rccm.201004-0670OC. Epub 2010 Sep 2.

  PMID: 20813887 RESULT

• Aarab Y, Pensier J, Garnier F, Monet C, Lakbar I, Chanques G, de Jong A, Capdevila M, Jaber S; FreeRea study group. Incidence and outcomes of extubation failure in mechanically ventilated patients with cirrhosis: a post-hoc analysis of a prospective multicenter study. Ann Intensive Care. 2025 Oct 16;15(1):160. doi: 10.1186/s13613-025-01576-3.

  PMID: 41099917 DERIVED

• De Jong A, Capdevila M, Aarab Y, Cros M, Pensier J, Lakbar I, Monet C, Quintard H, Cinotti R, Asehnoune K, Arnal JM, Guitton C, Paugam-Burtz C, Abback P, Mekontso-Dessap A, Lakhal K, Lasocki S, Plantefeve G, Claud B, Pottecher J, Corne P, Ichai C, Molinari N, Chanques G, Papazian L, Azoulay E, Jaber S; FREE-REA Study Group. Incidence, Risk Factors, and Long-Term Outcomes for Extubation Failure in ICU in Patients With Obesity: A Retrospective Analysis of a Multicenter Prospective Observational Study. Chest. 2025 Jan;167(1):139-151. doi: 10.1016/j.chest.2024.07.171. Epub 2024 Sep 7.

  PMID: 39182573 DERIVED

• Jaber S, Quintard H, Cinotti R, Asehnoune K, Arnal JM, Guitton C, Paugam-Burtz C, Abback P, Mekontso Dessap A, Lakhal K, Lasocki S, Plantefeve G, Claud B, Pottecher J, Corne P, Ichai C, Hajjej Z, Molinari N, Chanques G, Papazian L, Azoulay E, De Jong A. Risk factors and outcomes for airway failure versus non-airway failure in the intensive care unit: a multicenter observational study of 1514 extubation procedures. Crit Care. 2018 Sep 23;22(1):236. doi: 10.1186/s13054-018-2150-6.

  PMID: 30243304 DERIVED

Study Officials

• Samir JABER, PU-PH

  Hospital of Montpellier

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 18, 2015
• First Posted: May 21, 2015
• Study Start: December 19, 2013
• Primary Completion: July 4, 2015
• Study Completion: July 30, 2015
• Last Updated: April 21, 2017

Record last verified: 2017-03

Locations

FR (1)