Memory and Exercise Training Study in Older Adults With Subjective Memory Complaints

NCT02433691 | Completed DMC

• 1 other identifier: 14-001411
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This pilot study is a first step in a rapidly growing area of clinical research to create the most effective means to combat age-related losses in cognitive function through preventive lifestyle strategies such as physical exercise and memory training. This study will develop innovative simultaneous exercise and memory training programs in non-demented volunteers with subjective memory complaints (controls or MCI). Our primary goal is to assess the cognitive impact of 4-week memory training programs done twice weekly: 1. during simultaneous aerobic exercise (SIM-AR-MET), 2. sequentially after aerobic exercise (SEQ-AR-MET), or 3. without aerobic exercise (replaced with sequential stretching and toning) (SEQ-ST-MET). The investigators will also measure potential metabolic (e.g., glucose, lipid panel) and molecular (serum BDNF) mediators of observed cognitive changes in a subset of participants (those at the UCLA CTRC/IPCN site).

Conditions

Memory Impairment

Keywords

(An)aerobic exercise; memory training; cognitive benefits

Outcome Measures

Primary Outcomes (1)

• Effects of the MET interventions on cognition (comparing baseline vs. end-of-study NP testing)

  Change from baseline in composite measure of memory related tasks including retention, attention, and mood.

  up to 9 months

Secondary Outcomes (2)

• Changes in BDNF levels in response to the interventions

  up to 9 months

• Physical health measures

  up to 9 months

Study Arms (3)

Sequential Exercise and Memory Training

ACTIVE COMPARATOR

Aerobic exercise via stationary bicycling followed by memory training.

Other: sequential aerobic exercise

Simultaneous Exercise & Memory Training

EXPERIMENTAL

Simultaneous aerobic exercise via stationary bicycling while receiving memory training.

Other: simultaneous aerobic exercise

Stretching and Toning

PLACEBO COMPARATOR

Anerobic stretching and toning followed by memory training

Other: stretching and toning

Interventions

simultaneous aerobic exercise OTHER

stationary bicycling at 65% of heart rate reserve for 30 minutes while receiving memory training.

Simultaneous Exercise & Memory Training

sequential aerobic exercise OTHER

stationary bicycling at 65% of heart rate reserve for 30 minutes followed by memory training.

Sequential Exercise and Memory Training

stretching and toning OTHER

anaerobic stretching and toning followed by memory training.

Stretching and Toning

Eligibility Criteria

• Age: 60 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• In good health
• Have memory problems or complaints
• Living independently

You may not qualify if:

• History of neurodegenerative disease or dementia
• Major psychiatric conditions
• Neurological disorders
• Active alcohol or substance abuse
• Head trauma or systemic diseases affecting brain function
• Uncontrolled hypertension or cardiovascular disease

Sponsors & Collaborators

• David Merrill, MD, PhD: lead

Study Sites (1)

UCLA Longevity Center

Los Angeles, California, 90095, United States

Location

Related Publications (11)

• Miller KJ, Siddarth P, Gaines JM, Parrish JM, Ercoli LM, Marx K, Ronch J, Pilgram B, Burke K, Barczak N, Babcock B, Small GW. The memory fitness program: cognitive effects of a healthy aging intervention. Am J Geriatr Psychiatry. 2012 Jun;20(6):514-23. doi: 10.1097/JGP.0b013e318227f821.

  PMID: 21765343 RESULT

• Barnes DE, Yaffe K, Satariano WA, Tager IB. A longitudinal study of cardiorespiratory fitness and cognitive function in healthy older adults. J Am Geriatr Soc. 2003 Apr;51(4):459-65. doi: 10.1046/j.1532-5415.2003.51153.x.

  PMID: 12657064 RESULT

• Erickson KI, Miller DL, Roecklein KA. The aging hippocampus: interactions between exercise, depression, and BDNF. Neuroscientist. 2012 Feb;18(1):82-97. doi: 10.1177/1073858410397054. Epub 2011 Apr 29.

  PMID: 21531985 RESULT

• Goodwin VA, Richards SH, Taylor RS, Taylor AH, Campbell JL. The effectiveness of exercise interventions for people with Parkinson's disease: a systematic review and meta-analysis. Mov Disord. 2008 Apr 15;23(5):631-40. doi: 10.1002/mds.21922.

  PMID: 18181210 RESULT

• Hillman CH, Erickson KI, Kramer AF. Be smart, exercise your heart: exercise effects on brain and cognition. Nat Rev Neurosci. 2008 Jan;9(1):58-65. doi: 10.1038/nrn2298.

  PMID: 18094706 RESULT

• Petzinger GM, Fisher BE, McEwen S, Beeler JA, Walsh JP, Jakowec MW. Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease. Lancet Neurol. 2013 Jul;12(7):716-26. doi: 10.1016/S1474-4422(13)70123-6.

  PMID: 23769598 RESULT

• Barnes DE, Santos-Modesitt W, Poelke G, Kramer AF, Castro C, Middleton LE, Yaffe K. The Mental Activity and eXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults. JAMA Intern Med. 2013 May 13;173(9):797-804. doi: 10.1001/jamainternmed.2013.189.

  PMID: 23545598 RESULT

• Oswald WD, Rupprecht R, Gunzelmann T, Tritt K. The SIMA-project: effects of 1 year cognitive and psychomotor training on cognitive abilities of the elderly. Behav Brain Res. 1996 Jun;78(1):67-72. doi: 10.1016/0166-4328(95)00219-7.

  PMID: 8793039 RESULT

• Berchtold NC, Castello N, Cotman CW. Exercise and time-dependent benefits to learning and memory. Neuroscience. 2010 May 19;167(3):588-97. doi: 10.1016/j.neuroscience.2010.02.050. Epub 2010 Feb 26.

  PMID: 20219647 RESULT

• Rasmussen P, Brassard P, Adser H, Pedersen MV, Leick L, Hart E, Secher NH, Pedersen BK, Pilegaard H. Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp Physiol. 2009 Oct;94(10):1062-9. doi: 10.1113/expphysiol.2009.048512. Epub 2009 Aug 7.

  PMID: 19666694 RESULT

• McEwen SC, Siddarth P, Rahi B, Kim Y, Mui W, Wu P, Emerson ND, Lee J, Greenberg S, Shelton T, Kaiser S, Small GW, Merrill DA. Simultaneous Aerobic Exercise and Memory Training Program in Older Adults with Subjective Memory Impairments. J Alzheimers Dis. 2018;62(2):795-806. doi: 10.3233/JAD-170846.

  PMID: 29480182 DERIVED

MeSH Terms

Conditions

Memory Disorders

Condition Hierarchy (Ancestors)

Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Sarah McEwen, Ph.D.

  UCSD

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Clinical Professor

Study Record Dates

• First Submitted: April 13, 2015
• First Posted: May 5, 2015
• Study Start: January 1, 2015
• Primary Completion: June 1, 2017
• Study Completion: June 1, 2017
• Last Updated: May 2, 2018

Record last verified: 2018-04

Locations

US (1)