Longitudinal Follow-up of High School Athletes

NCT02432183 | Completed Results

• 1 other identifier: S53448
• Study Type: observational
• Target: 134
• Locations: 1 country
• Sites: 1

Brief Summary

In this study the investigators will study the lung function and airway inflammation in elite athletes starting at the elite sport school (age: 12-13 year) and the change in lung function parameters and airway inflammation after 1 and 2 years at the elite sport school in comparison to age-matched controls (exercising at a recreational level, \<4 hours/week).

Conditions

Elite Athlete; Healthy

Keywords

individual

Outcome Measures

Primary Outcomes (1)

• Maximal Fall in Forced Expiratory Volume in One-second (FEV1) After Eucapnic Voluntary Hyperventilation (EVH) Test

  percentage change in FEV1 after EHV test compared to baseline EVH test will be performed for 6 min at a target ventilation of 85% of the maximal voluntary ventilation (MVV), which will be determined before initiation of the test. Ventilation will be monitored during the 6-min test by a flow sensor (Jaeger Oxycon Mobile, Carefusion), FEV1 will be measured immediately after challenge and at 5, 10 and 15 min. A reduction in FEV1 ≥ 10% at one of the time points compared with the value before the test will be considered positive. Salbutamol (400 μg) will be given after the last spirometry (post-EVH) to check bronchodilator reversibility.

  change from baseline compared to 15 minutes after EVH test

Secondary Outcomes (1)

• Number of Participants With Allergies Determined by Positive Skin Prick Test

  baseline

Other Outcomes (1)

• Number of Sputum Uric Acid-high Subjects (Determined by ELISA on Sputum Supernatants)

  baseline

Study Arms (4)

Football players

Football players of the first grade of high school are recruited from the topsportschool in Leuven.

Basketball players

Basketball players of the first grade of high school are recruited from the topsportschool in Leuven.

Swimmers

Swimmers of the first grade of high school are recruited from the future team of the Flemish Swimming Federation

Control group

Age-matched controls are recruited (exercising at a recreational level, \>4 hours).

Eligibility Criteria

• Age: 11 Years - 15 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

A group of elite athletes at the start of their career (both from the elite sport school in Wilrijk (n=15) and Leuven (n=35) in cooperation with 'Sportmedisch Advies Centrum' (SMAC) UZ Leuven) are recruited. Three sport disciplines are included: basketball players, football players and swimmers. A group of healthy subjects (n=20) is recruited to serve as a control.

You may qualify if:

• Elite athletes from the elite sport school in Wilrijk and Leuven
• First grade of high school

You may not qualify if:

• Performing \>4hours/week sports

Sponsors & Collaborators

• Universitaire Ziekenhuizen KU Leuven: lead

Study Sites (1)

UZ Leuven

Leuven, Vlaams Brabant, 3000, Belgium

Location

Related Publications (3)

• Bonini M, Braido F, Baiardini I, Del Giacco S, Gramiccioni C, Manara M, Tagliapietra G, Scardigno A, Sargentini V, Brozzi M, Rasi G, Bonini S. AQUA: Allergy Questionnaire for Athletes. Development and validation. Med Sci Sports Exerc. 2009 May;41(5):1034-41. doi: 10.1249/MSS.0b013e318193c663.

  PMID: 19346984 BACKGROUND

• Van der Eycken S, Schelpe A, Marijsse G, Dilissen E, Troosters T, Vanbelle V, Aertgeerts S, Dupont LJ, Peers K, Bullens DM, Seys SF. Feasibility to apply eucapnic voluntary hyperventilation in young elite athletes. Respir Med. 2016 Feb;111:91-3. doi: 10.1016/j.rmed.2015.12.012. Epub 2016 Jan 4.

  PMID: 26790574 RESULT

• Jonckheere AC, Seys SF, Dilissen E, Marijsse G, Schelpe AS, Van der Eycken S, Verhalle T, Vanbelle V, Aertgeerts S, Troosters T, Peers K, Dupont LJ, Bullens DMA. AQUA(c) Questionnaire as prediction tool for atopy in young elite athletes. Pediatr Allergy Immunol. 2018 Sep;29(6):648-650. doi: 10.1111/pai.12949. Epub 2018 Jul 9. No abstract available.

  PMID: 29908073 RESULT

Biospecimen

Retention: SAMPLES WITH DNA

induced sputum sample and venous blood (serum)

Results Point of Contact

• Title: Dominique MA Bullens
• Organization: KU Leuven

dominique.bullens@kuleuven.be

3216341338

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: March 27, 2015
• First Posted: May 4, 2015
• Study Start: September 1, 2012
• Primary Completion: June 1, 2015
• Study Completion: December 1, 2015
• Last Updated: January 10, 2024
• Results First Posted: February 5, 2021

Record last verified: 2023-12

Locations

BE (1)