The Association Between Psoriasis and Intestinal Bacterial Population

NCT02417792 | Completed

• 1 other identifier: 2
• Study Type: observational
• Target: 46
• Locations: 0 countries
• Sites: N/A

Brief Summary

At least 20 psoriasis patients will be compared to at least 20 participants without psoriasis Bacterial genomic DNA will be extracted from stool samples of participants. The intestinal bacterial populations will be compared in order to examine whether there are differences between the groups.

Conditions

Psoriasis

Keywords

psoriasis; microbiota

Outcome Measures

Primary Outcomes (1)

• A significant change (P<0.05) in enteric bacterial composition of psoriasis patients (n=20) vs controls (n=20) as assessed by alpha diversity, beta diversity and taxonomic analysis.

  To examine whether fecal bacterial populations of psoriasis patients (not treated by enteral medications) are different compared to healthy participants

  2 years

Study Arms (3)

control

group of healthy participants

Topical psoriasis treatment

Group of patients who are treated with topical medications for psoriasis

Systemic psoriasis treatment

Group of patients who are treated with systematic medications for psoriasis

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Both psoriasis patients and healthy participants (as a control group) will be recruited for the study.

You may qualify if:

• Dermal psoriasis patients diagnosed by a dermatologist.

You may not qualify if:

• Treatment with antibiotics or probiotics within the prior 3 months.
• incapable of signing an inform concent.

Sponsors & Collaborators

• Assuta Hospital Systems: lead
• Tel Aviv Medical Center: collaborator

Related Publications (5)

• Shaw SY, Blanchard JF, Bernstein CN. Association between early childhood otitis media and pediatric inflammatory bowel disease: an exploratory population-based analysis. J Pediatr. 2013 Mar;162(3):510-4. doi: 10.1016/j.jpeds.2012.08.037. Epub 2012 Oct 17.

  PMID: 23084703 BACKGROUND

• Shaw SY, Blanchard JF, Bernstein CN. Association between the use of antibiotics in the first year of life and pediatric inflammatory bowel disease. Am J Gastroenterol. 2010 Dec;105(12):2687-92. doi: 10.1038/ajg.2010.398. Epub 2010 Oct 12.

  PMID: 20940708 BACKGROUND

• Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, Fierer N, Pena AG, Goodrich JK, Gordon JI, Huttley GA, Kelley ST, Knights D, Koenig JE, Ley RE, Lozupone CA, McDonald D, Muegge BD, Pirrung M, Reeder J, Sevinsky JR, Turnbaugh PJ, Walters WA, Widmann J, Yatsunenko T, Zaneveld J, Knight R. QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 2010 May;7(5):335-6. doi: 10.1038/nmeth.f.303. Epub 2010 Apr 11. No abstract available.

  PMID: 20383131 BACKGROUND

• Edgar RC. Search and clustering orders of magnitude faster than BLAST. Bioinformatics. 2010 Oct 1;26(19):2460-1. doi: 10.1093/bioinformatics/btq461. Epub 2010 Aug 12.

  PMID: 20709691 BACKGROUND

• Henseler T, Christophers E. Psoriasis of early and late onset: characterization of two types of psoriasis vulgaris. J Am Acad Dermatol. 1985 Sep;13(3):450-6. doi: 10.1016/s0190-9622(85)70188-0.

  PMID: 4056119 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

stool

MeSH Terms

Conditions

Psoriasis

Condition Hierarchy (Ancestors)

Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Jonathan Shapiro, Dr.

  Maccabi Healthcare Services, Israel

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 13, 2015
• First Posted: April 16, 2015
• Study Start: May 14, 2015
• Primary Completion: January 6, 2019
• Study Completion: February 18, 2019
• Last Updated: September 25, 2019

Record last verified: 2015-03