NCT02417025

Brief Summary

The purpose of this study is to determine whether a scientifically validated treatment for Posttraumatic Stress Disorder (PTSD) called Prolonged Exposure (PE) can be delivered effectively to Veterans with Military Sexual Trauma (MST) related PTSD using videoconferencing technology, which allows a therapist and patient who are not in the same room as one another to communicate. The investigators are interested in learning if this form of mental health service delivery is an acceptable alternative to traditional face-to-face therapy delivered with the therapist in the same room as the patient. This study is being conducted at the Charleston VA Medical Center and surrounding Community-Based Outpatient Clinics (CBOCs), and will involve approximately 100 female participants.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
136

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Aug 2014

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2014

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

December 15, 2014

Completed
4 months until next milestone

First Posted

Study publicly available on registry

April 15, 2015

Completed
4.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 29, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 29, 2019

Completed
Last Updated

December 24, 2019

Status Verified

December 1, 2019

Enrollment Period

5.3 years

First QC Date

December 15, 2014

Last Update Submit

December 23, 2019

Conditions

Keywords

MilitaryHealth Service DeliveryTelepsychologyProlonged ExposureOff-duty Activity of Military Personnel

Outcome Measures

Primary Outcomes (1)

  • Number of Participants Receiving Prolonged Exposure Treatment via Telemedicine with significantly decreased PTSD symptoms Compared to Number of Participants Receiving Prolonged Exposure Treatment with Standard In-Person Delivery

    36 weeks

Secondary Outcomes (40)

  • Veteran (VR) Short Form (SF) -12 Health Survey (VR-12)

    Baseline

  • Veteran (VR) Short Form (SF) -12 Health Survey (VR-12)

    13 weeks

  • Veteran (VR) Short Form (SF) -12 Health Survey (VR-12)

    24 weeks

  • Veteran (VR) Short Form (SF) -12 Health Survey (VR-12)

    36 weeks

  • Index of Functional Impairment (IFI)

    Baseline

  • +35 more secondary outcomes

Study Arms (2)

PE-HBT

EXPERIMENTAL

Prolonged Exposure via home-based telehealth (i.e., completed using videoconferencing technology)

Behavioral: PE

PE-SD

ACTIVE COMPARATOR

Prolonged Exposure via standard delivery (i.e., completed in person at the therapist's office)

Behavioral: PE

Interventions

PEBEHAVIORAL

Prolonged Exposure

PE-HBTPE-SD

Eligibility Criteria

Age21 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • MST-related index event
  • Diagnosis of PTSD-related MST
  • Female

You may not qualify if:

  • Having a household member of spouse who is already enrolled in the study
  • Active psychosis or dementia
  • Suicidal and/or homicidal ideation with clear intent
  • Current substance dependence
  • Concurrent enrollment in another clinical trial for PTSD or depression

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Ralph H. Johnson VAMC

Charleston, South Carolina, 29401, United States

Location

Related Publications (1)

  • Acierno R, Jaffe AE, Gilmore AK, Birks A, Denier C, Muzzy W, Lopez CM, Tuerk P, Grubaugh AL. A randomized clinical trial of in-person vs. home-based telemedicine delivery of Prolonged Exposure for PTSD in military sexual trauma survivors. J Anxiety Disord. 2021 Oct;83:102461. doi: 10.1016/j.janxdis.2021.102461. Epub 2021 Aug 8.

MeSH Terms

Conditions

Stress Disorders, Post-TraumaticCombat DisordersAnxiety DisordersMental DisordersStress Disorders, Traumatic

Condition Hierarchy (Ancestors)

Trauma and Stressor Related Disorders

Study Officials

  • Ronald E Acierno, PhD

    Ralph H. Johnson VA Medical Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 15, 2014

First Posted

April 15, 2015

Study Start

August 1, 2014

Primary Completion

November 29, 2019

Study Completion

November 29, 2019

Last Updated

December 24, 2019

Record last verified: 2019-12

Locations