Vitamin D Status and Immune Function
Vitamin D Status and in Vivo Immune Function
1 other identifier
observational
264
1 country
1
Brief Summary
The purpose of this study is to examine the relationship between Vitamin D status and immunity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2014
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2014
CompletedFirst Submitted
Initial submission to the registry
March 25, 2015
CompletedFirst Posted
Study publicly available on registry
April 15, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2015
CompletedApril 5, 2017
March 1, 2017
1.7 years
March 25, 2015
April 4, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
Vitamin D measured by liquid chromatography tandem mass spectroscopy
Circulating 25-hydroxy-vitamin D
Up to 20 months
Secondary Outcomes (1)
Immune function measured by analytic biochemistry assay
Up to 20 months
Study Arms (1)
Army recruits
Army recruits at the start of basic training will complete an in vivo immunity model
Interventions
Eligibility Criteria
Young adults who are starting basic training in the army.
You may qualify if:
- Passed medical assessment by medical doctor
- Passed audio test (this is part of medical assessment)
- Met physical fitness requirements
You may not qualify if:
- Medically deferred by medical doctor
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Bangor Universitylead
- University of East Angliacollaborator
Study Sites (1)
Infantry Training Centre
Catterick, North Yorkshire, DL9 3PS, United Kingdom
Related Publications (2)
Kashi DS, Oliver SJ, Wentz LM, Roberts R, Carswell AT, Tang JCY, Jackson S, Izard RM, Allan D, Rhodes LE, Fraser WD, Greeves JP, Walsh NP. Vitamin D and the hepatitis B vaccine response: a prospective cohort study and a randomized, placebo-controlled oral vitamin D3 and simulated sunlight supplementation trial in healthy adults. Eur J Nutr. 2021 Feb;60(1):475-491. doi: 10.1007/s00394-020-02261-w. Epub 2020 May 10.
PMID: 32390123DERIVEDTang JCY, Jackson S, Walsh NP, Greeves J, Fraser WD; Bioanalytical Facility team. The dynamic relationships between the active and catabolic vitamin D metabolites, their ratios, and associations with PTH. Sci Rep. 2019 May 6;9(1):6974. doi: 10.1038/s41598-019-43462-6.
PMID: 31061425DERIVED
Biospecimen
Blood serum collected at Week 1 (start of training) and Week 13 (end of training).
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Julie Greeves, PhD
HQ Army Research and Training Division
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 25, 2015
First Posted
April 15, 2015
Study Start
April 1, 2014
Primary Completion
December 1, 2015
Study Completion
December 1, 2015
Last Updated
April 5, 2017
Record last verified: 2017-03