Meibomian Gland Dysfunction (MGD) and Tear Cytokines After Cataract Surgery According to Preoperative Meibomian Gland Status
1 other identifier
observational
50
1 country
1
Brief Summary
To investigate the possible mechanisms by which cataract surgery aggravates meibomian gland dysfunction (MGD), the investigators evaluated the changes in tear cytokines and ocular surface parameters after cataract surgery according to the preoperative MGD grade.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Mar 2015
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 5, 2015
CompletedStudy Start
First participant enrolled
March 16, 2015
CompletedFirst Posted
Study publicly available on registry
April 8, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 3, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
August 3, 2015
CompletedJanuary 25, 2017
January 1, 2017
5 months
March 5, 2015
January 23, 2017
Conditions
Outcome Measures
Primary Outcomes (6)
inflammatory tear cytokine concentration
comparison of tear cytokines (IL-2,4,10,17a, INF-r, TNF-a) concentrations in patients with or without newly diagnosed chronic GVHD after SCT using a multiplex immunobead assay
1 month after cataract surgery
ocular surface staining
1 month after cataract surgery
tear film break-up time,
1 month after cataract surgery
conjunctival injection,
1 month after cataract surgery
Schirmer's test I
1 month after cataract surgery
ocular surface disease index
1 month after cataract surgery
Eligibility Criteria
A total of 55 eyes from 55 patients who underwent cataract surgery were included.
You may qualify if:
- males or non-pregnant females aged between 55 to 80 years-old.
You may not qualify if:
- had a history of ocular diseases, such as ocular infection, ocular allergy, and autoimmune disease, as well as patients with continuous use of topical ocular medications before surgery, or histories of ocular surgery or ocular injury.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Ophthalmology
Seoul, Seoul, 120-752, South Korea
Related Publications (2)
Li XM, Hu L, Hu J, Wang W. Investigation of dry eye disease and analysis of the pathogenic factors in patients after cataract surgery. Cornea. 2007 Oct;26(9 Suppl 1):S16-20. doi: 10.1097/ICO.0b013e31812f67ca.
PMID: 17881910BACKGROUNDCyclin-dependent kinase inhibitory protein expression in human choroidal melanoma tumors. Mouriaux F,*(1) Maurage CA, Labalette P, Sablonniere B, Malecaze F, Darbon JM. Inv Ophthalmol Vis Sci 2000;41:2837-2843. Am J Ophthalmol. 2001 Jan;131(1):157. doi: 10.1016/s0002-9394(00)00922-3. No abstract available.
PMID: 11341889BACKGROUND
Biospecimen
TEAR
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 5, 2015
First Posted
April 8, 2015
Study Start
March 16, 2015
Primary Completion
August 3, 2015
Study Completion
August 3, 2015
Last Updated
January 25, 2017
Record last verified: 2017-01