Intraocular Pressure and Hemodialysis Midwestern Brazil

NCT02405884 | Completed

• 1 other identifier: 20328813.0.0000.0037
• Study Type: interventional
• Target: 39
• Locations: 0 countries
• Sites: N/A

Brief Summary

Objective: To evaluate the variation in intraocular pressure in patients with chronic kidney disease, according to the time interval between hemodialysis sessions and to the influence of weight and blood pressure on intraocular pressure. Methods: This was a cross-sectional study in which 78 eyes of 39 patients on hemodialysis, at the Santa Casa de Misericordia de Goiânia hospital, were analyzed in June 2014. Patients were divided into groups according to the days on which they underwent hemodialysis. The mean, standard deviation, and median of the intraocular pressure, blood pressure, and weight were calculated. P-values \<0.05 were considered statistically significant.

Conditions

Renal Insufficiency, Chronic; Glaucoma

Keywords

Glaucoma; Renal Insufficiency, Chronic; Low Tension Glaucoma; Ocular Hypertension

Outcome Measures

Primary Outcomes (1)

• assess changes in intraocular pressure (mmHg) before and after hemodialysis

  baseline (before hemodialysis ) and end of hemodialysis ( four hours late)

Study Arms (1)

measurement of intraocular pressure

OTHER

Patients were divided into groups according to the days on which they underwent hemodialysis. Intraocular pressure was measured with a Kowa HA-2 Perkins applanation tonometer. The tonometry included three measurements in the central region of the cornea before and after hemodialysis. In all patients, the measurements were performed three times on the days when hemodialysis sessions were performed, with 24 hours between each session, and the means of the measurements were obtained. All parameters were measured under prior corneal anesthesia with 0.1% proparacaine and 0.25% fluorescein eye drops.

Other: Kowa HA-2 Perkins applanation tonometer.

Interventions

Kowa HA-2 Perkins applanation tonometer. OTHER

Patients were divided into groups according to the days on which they underwent hemodialysis. Intraocular pressure was measured with a Kowa HA-2 Perkins applanation tonometer. The tonometry included three measurements in the central region of the cornea before and after hemodialysis. In all patients, the measurements were performed three times on the days when hemodialysis sessions were performed, with 24 hours between each session, and the means of the measurements were obtained. All parameters were measured under prior corneal anesthesia with 0.1% proparacaine and 0.25% fluorescein eye drops.

measurement of intraocular pressure

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• chronic renal patients
• Patientes signed the informed consent form and were able to undergo a physical examination
• Patients between 18-75 years of age

You may not qualify if:

• Patients with chronic eye disease and / or eye surgery
• Patients allergic to anesthetic drops or dyes.
• Patients who had no physical condition to the eye examination
• Patients who refused to participate in the study

Sponsors & Collaborators

• VER Excelência em Oftalmologia: lead

Related Publications (1)

• Hu J, Bui KM, Patel KH, Kim H, Arruda JA, Wilensky JT, Vajaranant TS. Effect of hemodialysis on intraocular pressure and ocular perfusion pressure. JAMA Ophthalmol. 2013 Dec;131(12):1525-31. doi: 10.1001/jamaophthalmol.2013.5599.

  PMID: 24232671 BACKGROUND

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Glaucoma; Low Tension Glaucoma; Ocular Hypertension

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Eye Diseases; Optic Nerve Diseases

Study Officials

• Francisco W Rodrigues, Professor

  PUC Goias

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: ophthalmologist

Study Record Dates

• First Submitted: March 24, 2015
• First Posted: April 1, 2015
• Study Start: January 1, 2014
• Primary Completion: July 1, 2014
• Study Completion: October 1, 2014
• Last Updated: April 3, 2015

Record last verified: 2015-03