Importance of Patient Selection for Treatment of Infected Total Knee Prosthesis

NCT02405702 | Completed

• 1 other identifier: 007-14
• Study Type: observational
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

The infection of a total knee replacement often imposes changing implants. The change in two step is currently considered the gold standard. The change in one step is a much debated attitude: strictly contra-indicated for some professionals, but others agree to reserve these for favorable suspected cases selected. Several criteria have been proposed in the literature: age, condition, duration of infection, known bacterium responsible, not virulent and sensitive to antibiotics, no fistula, no significant bone destruction. But these criteria are poorly validated, standing over an experience of surgical teams rather than high-level scientific studies. Some authors have proposed to achieve change in one step systematically. The results of these cohorts on healing the infection does not seem very different from the changes in two steps. But it is most often single-center series, uncontrolled, with small numbers.

Conditions

Knee Infection

Keywords

Infection; Knee; knee replacement

Outcome Measures

Primary Outcomes (1)

• Recovery from the infection measured visually

  show that the selection process of patients used improve treatment outcomes of infection in total knee replacement

  for the duration of hospital stay, up to 1 year

Interventions

restrospective study OTHER

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients over 18 years having surgery for the management of knee infection after change in one step of a knee replacement prothesis in the participating services between 2000 and 2010.

You may qualify if:

• Patients over 18 years
• Patient having surgery for the management of knee infection after change in one step of a knee replacement prothesis in the participating services between 2000 and 2010.

You may not qualify if:

• Patients under 18 years

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

MeSH Terms

Conditions

Infections

Study Officials

• Jean-Yves JENNY, MD

  University Hospital, Strasbourg, France

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 25, 2015
• First Posted: April 1, 2015
• Study Start: March 1, 2015
• Primary Completion: January 31, 2016
• Study Completion: January 31, 2016
• Last Updated: September 5, 2025

Record last verified: 2025-09