NCT02403583

Brief Summary

The purpose of the study is to develop and pilot-test a home-based intervention to facilitate sate HIV testing and disclosure within pregnant couples in order to increase use of prevention-of-mother-to-child-transmission (PMTCT) and family health services in Kenya.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
233

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Aug 2014

Typical duration for not_applicable

Geographic Reach
1 country

5 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2014

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

February 24, 2015

Completed
1 month until next milestone

First Posted

Study publicly available on registry

March 31, 2015

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 31, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2017

Completed
Last Updated

April 6, 2017

Status Verified

April 1, 2017

Enrollment Period

2.7 years

First QC Date

February 24, 2015

Last Update Submit

April 4, 2017

Conditions

Keywords

HIV TransmissionPrevention of Mother to Child TransmissionSerodiscordancyHome-based testingHome-based counselingLinkage to careCouples HIV Testing and CounselingAcceptance of repeat HIV testing during pregnancyRetention in care

Outcome Measures

Primary Outcomes (2)

  • Utilization of maternal and child health (MCH) services (outcome for all couples in the study)

    Composite variable including at having completed least four antenatal care (ANC) visits during pregnancy (Y/N), childbirth with a skilled attendant (Y/N), and postnatal check-ups for woman (Y/N) and infant (Y/N). These are assessed in the follow-up questionnaire completed at three months after the baby's estimated due date.

    3 months after the expected due date of the baby

  • Use of PMTCT interventions (for HIV+ women only)

    Composite variable including mothers use of antiretrovirals (ARVs) (Y/N), prophylactic ARVs given to the infant (Y/N), and appropriate infant feeding mode (Y/N). These are assessed in the questionnaire completed at three months after the baby's estimated due date.

    3 months after the expected due date of the baby

Other Outcomes (2)

  • Couple HIV testing (all couples)

    3 months after the expected due date of the baby

  • Antenatal HIV testing (outcome for women who initially tested HIV-negative)

    3 months after the expected due date of the baby

Study Arms (2)

Intervention- Home visits

OTHER

Participants randomized to intervention arm receive 3 home visits conducted by one female and one male lay health worker.

Behavioral: Intervention- Home Visits

Standard Care

NO INTERVENTION

Participants will receive current standard clinic-based services including the option for women and partners to return to the clinic for male partner HIV testing or CHCT.

Interventions

If a woman has been randomized to the intervention arm, a lay health worker will obtain detailed locator information (including cell phone contacts) and consult with the woman about optimal times for a home visit. The woman will be given a letter for her male partner to inform him about the study and potential upcoming visits, given that our preliminary research revealed that notifying the male partner beforehand is important. As described above, the intervention arm will consist of three home visits conducted by one female and one male lay health worker.

Intervention- Home visits

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • (a) 18 years of age or older (b) 36 weeks of pregnancy or less (c) has been offered HIV testing at ANC, (d) is currently in a stable relationship (married or cohabiting) with a male partner of duration of at least 6 months (e) is currently living with a male partner who will be in residence at least one night a week at the home during the study period, (f) has not yet participated in couple HIV counseling and testing during this pregnancy (g) has not disclosed current HIV status to male partner (h) does not know with certainty the HIV-positive status of her male partner.

You may not qualify if:

  • (a) Currently pregnant (b) Greater than 36 weeks of pregnancy (c) Less than 18 years of age (d) Not currently in a stable relationship of at least 6 months (e) Does not currently live with male partner at least one night a week at the home (f) Has not been offered HIV testing (g) Has received CHCT with current male partner (h) has disclosed current HIV status to male partner (i) Knows with certainty current male partner is HIV-positive

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (5)

Macalder District Hospital

Migori, Migori County, Kenya

Location

Oyani Health Center

Migori, Migori County, Kenya

Location

Wath Onger

Othoch Rakuom, Migori County, Kenya

Location

Rongo District Hospital

Rongo, Migori County, Kenya

Location

God Jope Dispensary

Suna, Mirgori, Kenya

Location

Related Publications (1)

  • Turan JM, Darbes LA, Musoke PL, Kwena Z, Rogers AJ, Hatcher AM, Anderson JL, Owino G, Helova A, Weke E, Oyaro P, Bukusi EA. Development and Piloting of a Home-Based Couples Intervention During Pregnancy and Postpartum in Southwestern Kenya. AIDS Patient Care STDS. 2018 Mar;32(3):92-103. doi: 10.1089/apc.2017.0285.

MeSH Terms

Conditions

Acquired Immunodeficiency Syndrome

Condition Hierarchy (Ancestors)

HIV InfectionsBlood-Borne InfectionsCommunicable DiseasesInfectionsSexually Transmitted Diseases, ViralSexually Transmitted DiseasesLentivirus InfectionsRetroviridae InfectionsRNA Virus InfectionsVirus DiseasesSlow Virus DiseasesGenital DiseasesUrogenital DiseasesImmunologic Deficiency SyndromesImmune System Diseases

Study Officials

  • Janet M Turan, PhD

    University of Alabama at Birmingham

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

February 24, 2015

First Posted

March 31, 2015

Study Start

August 1, 2014

Primary Completion

March 31, 2017

Study Completion

March 31, 2017

Last Updated

April 6, 2017

Record last verified: 2017-04

Locations