An Analysis of Presentation and Outcome Following Treatment of Pancreatic Endocrine Neoplasms

NCT02400996 | Completed Results

• 1 other identifier: SGRH-SGLT-MTA
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

A single institutional study of Pancreatic Endocrine Neoplasms over 18 years.

Conditions

Pancreatic Endocrine Neoplasms

Keywords

Endocrine Pancreas; Pancreatic Endocrine Neoplasm

Outcome Measures

Primary Outcomes (1)

• Nonfunctioning and Malignant Pancreatic Endocrine Neoplasms

  Of the 40 patients operated for Pancreatic Endocrine Neoplasms, using clinical criteria, histopathological analysis and preoperative imaging as gold standard, nonfunctioning and functioning tumours were identified. Similarly the number of benign and malignant lesions identified were recorded as per the WHO Classification of pancreatic endocrine tumours.

  Each participant was followed up for a period of 5 years

Study Arms (1)

Pancreatic Endocrine Neoplasms

We did an observational analysis from a prospectively maintained database of patients who underwent pancreatic surgery for neoplasms of the pancreas at Sir Ganga Ram Hospital, New Delhi, India from 1995 to 2013 and using pathological reports and preoperative CT scan as gold standard, we identified 40 patients with PENs.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Medical files and electronic records were reviewed to collect information. Patients were categorized into functioning and nonfunctioning PENs based on their clinical behaviour, pathology reports and serum radioimmunoassay for offending hormones. Preoperative CT scans were used to characterize PENs and record neoplasm size and location in the pancreas. Review of operative notes was done for the type of surgery performed and peroperative findings recorded. Discharge summaries were used to study the surgical outcome in terms of duration of postoperative hospital stay and postoperative complications. Patients were followed up and any disease recurrence or disease related mortality was recorded. Evaluation of the pathology reports was done.

You may qualify if:

• Pathological reports and Prooperative CAT Scan showing Endocrine Pancreatic Tumours

You may not qualify if:

• Nonendocrine Pancreatic Tumours

Sponsors & Collaborators

• Medical College and Hospital Kolkata: lead
• Sir Ganga Ram Hospital: collaborator

Related Publications (5)

• Vortmeyer AO, Huang S, Lubensky I, Zhuang Z. Non-islet origin of pancreatic islet cell tumors. J Clin Endocrinol Metab. 2004 Apr;89(4):1934-8. doi: 10.1210/jc.2003-031575.

  PMID: 15070966 BACKGROUND

• Halfdanarson TR, Rabe KG, Rubin J, Petersen GM. Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival. Ann Oncol. 2008 Oct;19(10):1727-33. doi: 10.1093/annonc/mdn351. Epub 2008 May 30.

  PMID: 18515795 BACKGROUND

• Kazanjian KK, Reber HA, Hines OJ. Resection of pancreatic neuroendocrine tumors: results of 70 cases. Arch Surg. 2006 Aug;141(8):765-9; discussion 769-70. doi: 10.1001/archsurg.141.8.765.

  PMID: 16924083 RESULT

• Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL, Fernandez-Del Castillo C. Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005. Arch Surg. 2007 Apr;142(4):347-54. doi: 10.1001/archsurg.142.4.347.

  PMID: 17438169 RESULT

• Heitz PU, Komminoth P, Perrin A et al. Pancreatic endocrine tumors: Introduction. In: DeLellis DA, Lloyd RV, Heitz PU, et al., eds. Pathology and Genetics of Tumours of Endocrine Organs. WHO Classification of Tumours. Lyon, France: IARC Press, 2004: 177-82.

  RESULT

MeSH Terms

Conditions

Adenoma, Islet Cell

Condition Hierarchy (Ancestors)

Adenoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Pancreatic Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Endocrine Gland Neoplasms; Digestive System Diseases; Pancreatic Diseases; Endocrine System Diseases

Limitations and Caveats

The analysis was done from a prospectively maintained database and target followup done for a period of 5 years after surgery

Results Point of Contact

• Title: Md Tanveer Adil
• Organization: Sir Ganga Ram Hospital, New Delhi, India

tanveer.cmc@gmail.com

0091-9830154566

Study Officials

• Md Tanveer Adil

  Sir Ganga Ram Hospital, New Delhi

  PRINCIPAL INVESTIGATOR

• Raghavendra Nagaraja

  Sir Ganga Ram Hospital, New Delhi

  STUDY DIRECTOR

• Vibha Varma

  Sir Ganga Ram Hospital, New Delhi

  STUDY DIRECTOR

• Naimish Mehta

  Sir Ganga Ram Hospital, New Delhi

  STUDY DIRECTOR

• Vinay Kumaran

  Sir Ganga Ram Hospital, New Delhi

  STUDY DIRECTOR

• Samiran Nundy

  Sir Ganga Ram Hospital, New Delhi

  STUDY CHAIR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Fellow

Study Record Dates

• First Submitted: March 23, 2015
• First Posted: March 27, 2015
• Study Start: March 1, 2011
• Primary Completion: June 1, 2011
• Study Completion: November 1, 2014
• Last Updated: April 29, 2015
• Results First Posted: April 29, 2015

Record last verified: 2015-04