Sustained Attention Abilities in Schizophrenia

NCT02388607 | Unknown

• 1 other identifier: 5972
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Schizophrenia is a psychiatric pathology, which concerns around 1% of adult population. It is characterized by clinical symptoms combining positive and negative symptoms and thinking disorganization. Schizophrenia is also characterized by cognitive deficits, likely to play an important part in adaptation of these patients in their every-day life, and to affect their clinical symptomatology. Among them, there are deficits in sustained attention which are associated with a difficulty for these patients to maintain efficiently their cognitive activity on a source of stimulation or task. This basic attentional process is fundamental for the efficiency of the overall of cognitive processes, and so for all behaviors directed on an aim. The question of whether or not patients with schizophrenia have difficulty sustaining attention is of high relevance, in the sense that it could undermine performance on nearly any task and so provide a compelling causal explanation of many other impairments observed in these patients. Yet it has not been conclusively answered in over four decades of research. Consequently, the main objective of the protocol is to evaluate sustained attention abilities in schizophrenic patients and to better understand the specific functioning of cognitive and neural mechanisms underlying these abilities (attentional resources and cognitive control mechanisms).

Conditions

Schizophrenic Psychoses

Outcome Measures

Primary Outcomes (1)

• Assess sustained attention span of patients with schizophrenia

  Subjects are involved in 4 different attentional tasks during which behavioral and electrophysiological measures are recorded in order to evaluate sustained attention abilities and the specific functioning of cognitive and neural mechanisms underlying these abilities in schizophrenic patients.

  two half-days

Secondary Outcomes (1)

• Study the specific mechanisms underlying attention skills supported in schizophrenic patients

  two half-days

Study Arms (1)

assessing attention span

* Electrophysiological measurements (evocated potentials and spectral densities) * Clinical scales and subjective assessments of difficulty of the tasks performed, and commitment to the task

Other: measurements

Interventions

measurements OTHER

performance measurements

assessing attention span

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

40 schizophrenic patients versus 40 healthy subjects matched

You may qualify if:

• age between 18 and 60 years (include)
• men or women volunteers, hospitalized or not
• subject affiliated to an health insurance
• subject having signed an informed consent (for patients):
• presence of DSM-IV TR criteria for schizophrenia (American Psychiatric Association, 1994)

You may not qualify if:

• a major somatic disorder or non stabilized
• medical history likely to affect cerebral anatomy or to be linked to an abnormality (neonatal distress, neurochirurgical intervention, neurological disorders, stroke attack)
• any disorders involved in the use of a psycho-active substance (as defined by the DSM-IV)
• sensory disabling impairments, and specifically visual acuity \< 8
• general anaesthesia during the 3 months before the study
• pregnancy (declared by the subject)
• persons in an emergency situation
• persons deprived in any way of their liberty
• use of psychotropic substance during the 3 weeks before the study
• use of benzodiazepines

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Service de psychiatrie

Strasbourg, 67000, France

RECRUITING

MeSH Terms

Interventions

Weights and Measures

Intervention Hierarchy (Ancestors)

Investigative Techniques

Study Officials

• Giersch Anne, MD

  Les Hôpitaux Universitaires de Strasbourg

  PRINCIPAL INVESTIGATOR

• Bonnefond Anne, PHD

  Institut National de la Santé Et de la Recherche Médicale, France

  STUDY CHAIR

Central Study Contacts

Dimitri Sanchez

CONTACT

drci@chru-strasbourg.fr

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 10, 2014
• First Posted: March 17, 2015
• Study Start: March 1, 2015
• Primary Completion: March 1, 2023
• Study Completion: March 1, 2023
• Last Updated: September 14, 2021

Record last verified: 2021-09

Locations

FR (1)