The Impact of Topical Prostaglandins on the Biomechanical Properties of the Cornea in Patients With Open Angle Glaucoma

NCT02388360 | Completed Phase 4 DMC

• 1 other identifier: MaisonneuveRH
• Study Type: interventional
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine the influence of topical prostaglandin analog (PGA) medication on corneal biomechanical properties in patients undergoing PGA treatment for open-angle glaucoma.

Conditions

Glaucoma, Open-Angle

Keywords

Prostaglandin analogs; Corneal biomechanics; Corneal Hysteresis; Glaucoma, Open-Angle

Outcome Measures

Primary Outcomes (1)

• The Corneal Hysteresis (in mmHg) difference in patient with PGAs and without PGAs based on the integrated analysis of the data collected from the Reichert Ocular Response Analyzer (ORA)

  12 weeks

Secondary Outcomes (3)

• The intraocular pressure (in mmHg) difference in patient with PGAs and without PGAs based on the integrated analysis of the data collected from Goldmann tonometry

  12 weeks

• The corneal thickness (in µm) difference in patient with PGAs and without PGAs based on the integrated analysis of the data collected from pachymetry

  12 weeks

• The Corneal Resistance Factor (in mmHg) difference in patient with PGAs and without PGAs based on the integrated analysis of the data collected from the Reichert Ocular Response Analyzer (ORA)

  12 weeks

Study Arms (1)

topical prostaglandin analogs

OTHER

Drug: topical prostaglandin analogs

Interventions

topical prostaglandin analogs DRUG

topical prostaglandin analogs

Eligibility Criteria

• Age: 40 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patients with bilateral open angle glaucoma on monotherapy with topical PGA medication in both eyes

You may not qualify if:

• corneal disease (such as Fuchs' endothelial dystrophy or keratoconus)
• past history of corneal trauma or surgery (including refractive surgery) that may affect hysteresis measurements
• contact lens wearers
• uncontrolled glaucoma or advanced visual field (VF) damage (mean defect \< -12.0 db)
• patients taking systemic prostaglandin medication, non-steroidal anti-inflammatory drugs, or undergoing hormone replacement therapy

Sponsors & Collaborators

• Maisonneuve-Rosemont Hospital: lead

Study Sites (1)

Montreal Glaucoma Institut

Montreal, Quebec, H1V 1G5, Canada

Location

Related Publications (32)

• Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006 Mar;90(3):262-7. doi: 10.1136/bjo.2005.081224.

  PMID: 16488940 BACKGROUND

• Terai N, Raiskup F, Haustein M, Pillunat LE, Spoerl E. Identification of biomechanical properties of the cornea: the ocular response analyzer. Curr Eye Res. 2012 Jul;37(7):553-62. doi: 10.3109/02713683.2012.669007. Epub 2012 May 4.

  PMID: 22559332 BACKGROUND

• Touboul D, Roberts C, Kerautret J, Garra C, Maurice-Tison S, Saubusse E, Colin J. Correlations between corneal hysteresis, intraocular pressure, and corneal central pachymetry. J Cataract Refract Surg. 2008 Apr;34(4):616-22. doi: 10.1016/j.jcrs.2007.11.051.

  PMID: 18361984 BACKGROUND

• Ottino P, He J, Axelrad TW, Bazan HE. PAF-induced furin and MT1-MMP expression is independent of MMP-2 activation in corneal myofibroblasts. Invest Ophthalmol Vis Sci. 2005 Feb;46(2):487-96. doi: 10.1167/iovs.04-0852.

  PMID: 15671273 BACKGROUND

• Luce DA. Determining in vivo biomechanical properties of the cornea with an ocular response analyzer. J Cataract Refract Surg. 2005 Jan;31(1):156-62. doi: 10.1016/j.jcrs.2004.10.044.

  PMID: 15721708 BACKGROUND

• Roberts C. The cornea is not a piece of plastic. J Refract Surg. 2000 Jul-Aug;16(4):407-13. doi: 10.3928/1081-597X-20000701-03. No abstract available.

  PMID: 10939720 BACKGROUND

• Glass DH, Roberts CJ, Litsky AS, Weber PA. A viscoelastic biomechanical model of the cornea describing the effect of viscosity and elasticity on hysteresis. Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3919-26. doi: 10.1167/iovs.07-1321. Epub 2008 Jun 6.

  PMID: 18539936 BACKGROUND

• Roberts C. Biomechanics of the cornea and wavefront-guided laser refractive surgery. J Refract Surg. 2002 Sep-Oct;18(5):S589-92. doi: 10.3928/1081-597X-20020901-18.

  PMID: 12361163 BACKGROUND

• Detry-Morel M, Jamart J, Hautenauven F, Pourjavan S. Comparison of the corneal biomechanical properties with the Ocular Response Analyzer(R) (ORA) in African and Caucasian normal subjects and patients with glaucoma. Acta Ophthalmol. 2012 Mar;90(2):e118-24. doi: 10.1111/j.1755-3768.2011.02274.x. Epub 2011 Oct 11.

  PMID: 21989354 BACKGROUND

• Congdon NG, Broman AT, Bandeen-Roche K, Grover D, Quigley HA. Central corneal thickness and corneal hysteresis associated with glaucoma damage. Am J Ophthalmol. 2006 May;141(5):868-75. doi: 10.1016/j.ajo.2005.12.007. Epub 2006 Mar 9.

  PMID: 16527231 BACKGROUND

• Agarwal DR, Ehrlich JR, Shimmyo M, Radcliffe NM. The relationship between corneal hysteresis and the magnitude of intraocular pressure reduction with topical prostaglandin therapy. Br J Ophthalmol. 2012 Feb;96(2):254-7. doi: 10.1136/bjo.2010.196899. Epub 2011 Mar 24.

  PMID: 21436180 BACKGROUND

• Tsikripis P, Papaconstantinou D, Koutsandrea C, Apostolopoulos M, Georgalas I. The effect of prostaglandin analogs on the biomechanical properties and central thickness of the cornea of patients with open-angle glaucoma: a 3-year study on 108 eyes. Drug Des Devel Ther. 2013 Oct 4;7:1149-56. doi: 10.2147/DDDT.S50622. eCollection 2013.

  PMID: 24115838 BACKGROUND

• Shah S, Laiquzzaman M, Cunliffe I, Mantry S. The use of the Reichert ocular response analyser to establish the relationship between ocular hysteresis, corneal resistance factor and central corneal thickness in normal eyes. Cont Lens Anterior Eye. 2006 Dec;29(5):257-62. doi: 10.1016/j.clae.2006.09.006. Epub 2006 Nov 7.

  PMID: 17085066 BACKGROUND

• Detry-Morel M, Jamart J, Pourjavan S. Evaluation of corneal biomechanical properties with the Reichert Ocular Response Analyzer. Eur J Ophthalmol. 2011 Mar-Apr;21(2):138-48. doi: 10.5301/ejo.2010.2150.

  PMID: 20853262 BACKGROUND

• Wells AP, Garway-Heath DF, Poostchi A, Wong T, Chan KC, Sachdev N. Corneal hysteresis but not corneal thickness correlates with optic nerve surface compliance in glaucoma patients. Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3262-8. doi: 10.1167/iovs.07-1556. Epub 2008 Mar 3.

  PMID: 18316697 BACKGROUND

• Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Kass MA. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002 Jun;120(6):714-20; discussion 829-30. doi: 10.1001/archopht.120.6.714.

  PMID: 12049575 BACKGROUND

• Lopilly Park HY, Kim JH, Lee KM, Park CK. Effect of prostaglandin analogues on tear proteomics and expression of cytokines and matrix metalloproteinases in the conjunctiva and cornea. Exp Eye Res. 2012 Jan;94(1):13-21. doi: 10.1016/j.exer.2011.10.017. Epub 2011 Nov 4.

  PMID: 22067128 BACKGROUND

• Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res. 2003 May 2;92(8):827-39. doi: 10.1161/01.RES.0000070112.80711.3D.

  PMID: 12730128 BACKGROUND

• Weinreb RN, Lindsey JD, Marchenko G, Marchenko N, Angert M, Strongin A. Prostaglandin FP agonists alter metalloproteinase gene expression in sclera. Invest Ophthalmol Vis Sci. 2004 Dec;45(12):4368-77. doi: 10.1167/iovs.04-0413.

  PMID: 15557445 BACKGROUND

• Ottino P, Taheri F, Bazan HE. Platelet-activating factor induces the gene expression of TIMP-1, -2, and PAI-1: imbalance between the gene expression of MMP-9 and TIMP-1 and -2. Exp Eye Res. 2002 Mar;74(3):393-402. doi: 10.1006/exer.2001.1135.

  PMID: 12014920 BACKGROUND

• Tao Y, Bazan HE, Bazan NG. Platelet-activating factor enhances urokinase-type plasminogen activator gene expression in corneal epithelium. Invest Ophthalmol Vis Sci. 1996 Sep;37(10):2037-46.

  PMID: 8814143 BACKGROUND

• Lindsey JD, Kashiwagi K, Kashiwagi F, Weinreb RN. Prostaglandins alter extracellular matrix adjacent to human ciliary muscle cells in vitro. Invest Ophthalmol Vis Sci. 1997 Oct;38(11):2214-23.

  PMID: 9344344 BACKGROUND

• Lindsey JD, Kashiwagi K, Kashiwagi F, Weinreb RN. Prostaglandin action on ciliary smooth muscle extracellular matrix metabolism: implications for uveoscleral outflow. Surv Ophthalmol. 1997 Feb;41 Suppl 2:S53-9. doi: 10.1016/s0039-6257(97)80008-2.

  PMID: 9154277 BACKGROUND

• Mankus C, Chi C, Rich C, Ren R, Trinkaus-Randall V. The P2X(7) receptor regulates proteoglycan expression in the corneal stroma. Mol Vis. 2012;18:128-38. Epub 2012 Jan 18.

  PMID: 22275804 BACKGROUND

• Mayo C, Ren R, Rich C, Stepp MA, Trinkaus-Randall V. Regulation by P2X7: epithelial migration and stromal organization in the cornea. Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4384-91. doi: 10.1167/iovs.08-1688. Epub 2008 May 23.

  PMID: 18502993 BACKGROUND

• Kataoka A, Tozaki-Saitoh H, Koga Y, Tsuda M, Inoue K. Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT. J Neurochem. 2009 Jan;108(1):115-25. doi: 10.1111/j.1471-4159.2008.05744.x. Epub 2008 Nov 10.

  PMID: 19014371 BACKGROUND

• Sagara T, Gaton DD, Lindsey JD, Gabelt BT, Kaufman PL, Weinreb RN. Topical prostaglandin F2alpha treatment reduces collagen types I, III, and IV in the monkey uveoscleral outflow pathway. Arch Ophthalmol. 1999 Jun;117(6):794-801. doi: 10.1001/archopht.117.6.794.

  PMID: 10369592 BACKGROUND

• Chronopoulos A, Tang A, Beglova E, Trackman PC, Roy S. High glucose increases lysyl oxidase expression and activity in retinal endothelial cells: mechanism for compromised extracellular matrix barrier function. Diabetes. 2010 Dec;59(12):3159-66. doi: 10.2337/db10-0365. Epub 2010 Sep 7.

  PMID: 20823103 BACKGROUND

• Mathew JH, Bergmanson JP, Doughty MJ. Fine structure of the interface between the anterior limiting lamina and the anterior stromal fibrils of the human cornea. Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3914-8. doi: 10.1167/iovs.07-0707.

  PMID: 18765633 BACKGROUND

• Scott JE, Dyne KM, Thomlinson AM, Ritchie M, Bateman J, Cetta G, Valli M. Human cells unable to express decoron produced disorganized extracellular matrix lacking "shape modules" (interfibrillar proteoglycan bridges). Exp Cell Res. 1998 Aug 25;243(1):59-66. doi: 10.1006/excr.1998.4089.

  PMID: 9716449 BACKGROUND

• He J, Bazan NG, Bazan HE. Alkali-induced corneal stromal melting prevention by a novel platelet-activating factor receptor antagonist. Arch Ophthalmol. 2006 Jan;124(1):70-8. doi: 10.1001/archopht.124.1.70.

  PMID: 16401787 BACKGROUND

• Meda R, Wang Q, Paoloni D, Harasymowycz P, Brunette I. The impact of chronic use of prostaglandin analogues on the biomechanical properties of the cornea in patients with primary open-angle glaucoma. Br J Ophthalmol. 2017 Feb;101(2):120-125. doi: 10.1136/bjophthalmol-2016-308432. Epub 2016 May 9.

  PMID: 27162226 DERIVED

MeSH Terms

Conditions

Glaucoma, Open-Angle

Interventions

Prostaglandins, Synthetic

Condition Hierarchy (Ancestors)

Glaucoma; Ocular Hypertension; Eye Diseases

Intervention Hierarchy (Ancestors)

Prostaglandins; Eicosanoids; Fatty Acids, Unsaturated; Fatty Acids; Lipids; Autacoids; Inflammation Mediators; Biological Factors

Study Officials

• Paul Harasymowycz, Dr

  Maisonneuve-Rosemont Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Paul Harasymowycz, MD

Study Record Dates

• First Submitted: December 20, 2014
• First Posted: March 17, 2015
• Study Start: May 6, 2013
• Primary Completion: June 30, 2016
• Study Completion: November 16, 2016
• Last Updated: February 26, 2021

Record last verified: 2021-02

Locations

CA (1)