Impairment of Central Coherence in Restrictive Anorexia Nervosa (CoCA)

NCT02381639 | Completed

• 1 other identifier: RC14_0301
• Study Type: interventional
• Target: 122
• Locations: 1 country
• Sites: 1

Brief Summary

The current etiological pathological model of anorexia nervosa is poly-factorial involving individual genetic and psychological factors, in close interaction with environmental, family and socio-cultural factors. Among these factors, this study focuses on the central coherence process (cognitive ability to integrate complex information into a comprehensive meaning), in the active phase of the disease. Therefore, patients followed in the addiction service of the Nantes University Hospital will perform neuropsychological tests assessing executive functions involved in the process of central coherence. Impairment of central coherence process could act as a maintenance factor of the disease, particularly in connection with body dysmorphic disorder. The therapeutic perspectives acting on the central coherence process like cognitive remediation deserve to deepen knowledge on the cognitive profile of patients with anorexia nervosa.

Conditions

Anorexia Nervosa

Outcome Measures

Primary Outcomes (1)

• Percentages for types I and III of the copy of the figure of Rey

  90 minutes

Secondary Outcomes (2)

• Average scores for all cognitive and psychiatric tests

  90 minutes

• Measure of relationships between average scores for all cognitive and psychiatric tests and socio-demographic and clinical data

  90 minutes

Study Arms (2)

Patients

OTHER

patients followed in the addiction service of the University Hospital of Nantes (consultations and / or hospitalizations) for restrictive anorexia nervosa

Behavioral: One interview of 90 minutes with a part of cognitive assessment and a part of self-assessment

Healthy volunteers

OTHER

control subjects matched for age and sex with the patients

Behavioral: One interview of 90 minutes with a part of cognitive assessment and a part of self-assessment

Interventions

One interview of 90 minutes with a part of cognitive assessment and a part of self-assessment BEHAVIORAL

The content of the assessment will be the same for all subjects and will consist of a part of cognitive assessment (National Reading Test, Rey Osterreich Complex Figure, Hayling Sentence Completion Task, verbal memory, digit sequencing, token motor task, verbal fluencies, symbol coding, tower of London) and self-assessment (Mini International Neuropsychiatric Interview, Beck Depression Inventory, State Trait Anxiety Inventory, Wender Utah Rating Scale, Adult Self-Report Scale Symptom Checklist, UPPS Impulsive Behavior Scale)

Healthy volunteers; Patients

Eligibility Criteria

• Age: 15 Years+
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• For the patients :
• Woman.
• Aged of more than 15 years and 3 months.
• Followed in the addiction service of the University Hospital of Nantes (consultations and / or hospitalizations) for Restrictive Anorexia Nervosa (according to the diagnostic criteria of DSM-IV-TR).
• French language mastered.
• Having signed the consent if major and if not the legal representatives have signed the consent (for minors).
• For the volunteers :
• Women.
• Aged of more than 15 years and 3 months.
• French language mastered.
• Having signed the consent if major and if not the legal representatives have signed the consent (for minors).

You may not qualify if:

• For the patients :
• Man
• Age under 15 years and 3 months old
• Current Renutrition by nasogastric tube
• Personal history of:
• Head injury, neurodegenerative diseases, epilepsy unbalanced, unbalanced endocrine disorder, mental retardation
• Support for current or past cognitive remediation
• Opposition of the patient and / or his legal representatives if minor
• Subject under legal guardianship
• Current participation or in the past to pharmacological research protocol (time since the end of their participation in the protocol less than one year)
• French language not mastered
• For the volunteers :
• Man
• Age under 15 years and 3 months old
• Current Renutrition by nasogastric tube

Sponsors & Collaborators

• Nantes University Hospital: lead

Study Sites (1)

CHU de Nantes, Service d'Addictologie

Nantes, France

Location

MeSH Terms

Conditions

Anorexia Nervosa

Condition Hierarchy (Ancestors)

Feeding and Eating Disorders; Mental Disorders

Study Officials

• Jennyfer CHOLET

  Service d'Addictologie, CHU de Nantes, 44093 Nantes cedex 01, FRANCE

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2015
• First Posted: March 6, 2015
• Study Start: June 11, 2015
• Primary Completion: August 16, 2017
• Study Completion: August 16, 2017
• Last Updated: March 29, 2018

Record last verified: 2017-09

Locations

FR (1)