Metabolic Cost of Sitting, Standing, and Transitions

NCT02377037 | Completed DMC

• 1 other identifier: Transitions study
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

There is already a lot of scientific evidence supporting the benefits of public health recommendations regarding physical activity (the accumulation of at least 150 minutes of at least moderate intensity physical activity per week). However, these 30 daily minutes represent only about 3% of the waking period. Recent data suggest that most of the population spends on average 8-9 hours / day of sedentary behavior (SB). SB is characterized by any activity with a metabolic cost (MC) below 1.5 METs, mainly actions in the sitting position. In fact, there is evidence that the more time spent sitting higher the risk of disease and mortality, with sitting directly associated with diseases such as type II diabetes, cardiovascular diseases and even cancer. The average life expectancy may increase by \~ 2 years if the investigators reduce sitting about 3h/ day. Additionally, how people accumulate sitting time seems to be a major factor, with prolonged sitting associated with a higher risk of disease. Short-term experimental studies indicate that sedentary lifestyles affect energy balance enhancing weight gain. While there is some research regarding the MC associated with "sitting" and "standing" behaviors, the results are contradictory. Besides these conflicting results, the impact of transitions between these two types of behavior and how these transitions can contribute to MC increase have never been investigated. Our hypothesis is that, in both men and women, the simple replacement of sitting for "standing" may not substantially increase MC, but instead, the largest contribution may reside on the transitions between these two states of behavior. Therefore, the investigators will perform a study with the following purposes: Examine MC and HR associated with "sitting", "standing", and transitions between these two types of behavior in adults of both gender, apparently healthy with variable body composition profiles.

Conditions

Metabolic Cost

Keywords

Sitting; Standing; Transitions

Outcome Measures

Primary Outcomes (1)

• Metabolic cost

  The MC will be estimated using an open-circuit spirometry system (MedGraphics Corporation, Breezeex Software). Each participant will have to complete 4 periods (conditions) of 10 minutes in which the calorimeter device is attached to the mask and breath-by-breath VO2 and VCO2 are measured for 40 minutes.

  60 minutes (30 from metabolic rest and 30 from conditions)

Secondary Outcomes (1)

• Heart rate

  60 minutes (30 from metabolic rest and 30 from conditions)

Study Arms (3)

Sitting

EXPERIMENTAL

Remain seated in a chair, with hands placed on top of the thighs for 10 minutes, remaining motionless in which the calorimeter device is attached to the mask and breath-by-breath VO2 and VCO2 are measured minute by minute.

Other: Metabolic cost and HR associated with distinct postural behaviors

Standing

EXPERIMENTAL

Remain in an upright position (standing) with hands placed on the thighs for 10 minutes, remaining motionless in which the calorimeter device is attached to the mask and breath-by-breath VO2 and VCO2 are measured minute by minute.

Other: Metabolic cost and HR associated with distinct postural behaviors

Transitions sit/stand

EXPERIMENTAL

The participant will perform one sit-to-stand followed by a stand-to-sit transition, every minute in which the calorimeter device is attached to the mask and breath-by-breath VO2 and VCO2 are measured.

Other: Metabolic cost and HR associated with distinct postural behaviors

Interventions

Metabolic cost and HR associated with distinct postural behaviors OTHER

The order of the three conditions will be randomly assigned and all will be undertaken in laboratory settings. Before engaging in the experimental conditions participants will perform anthropometric and body composition assessments and also the resting EE evaluation. All evaluations will be performed at one time only, starting at 7:00 am in the morning after an overnight fast

Sitting; Standing; Transitions sit/stand

Eligibility Criteria

• Age: 18 Years - 64 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Men and women aged 18-64 years and without major metabolic, pulmonary, and cardiac disorders and general health guaranteed.
• Physically independent and able to perform all the conditions without limitations.

You may not qualify if:

• Pregnancy or engagement in any weight loss program that may affect energy balance.

Sponsors & Collaborators

• Technical University of Lisbon: lead

Study Sites (1)

Exercise and Health Laboratory, Faculdade de Motricidade Humana, Universidade de Lisboa

Cruz Quebrada, Lisbon District, 1495, Portugal

Location

Related Publications (23)

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  BACKGROUND

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Study Officials

• Analiza M Silva, PhD

  Laboratory of Exercise and Health, Faculadde Motricidade Humana, Universidade de Lisboa

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 18, 2015
• First Posted: March 3, 2015
• Study Start: November 1, 2014
• Primary Completion: February 1, 2015
• Study Completion: February 1, 2015
• Last Updated: March 3, 2015

Record last verified: 2015-02

Locations

PT (1)