Sequence Variations of Genes in the Estrogen Pathway and Perinatal Depression

NCT02373709 | Active Not Recruiting DMC

• 1 other identifier: 2010/539/F
• Study Type: observational
• Target: 750
• Locations: 1 country
• Sites: 1

Brief Summary

To elucidate the disease pathway of perinatal depression by identifying genetic variants which could play a role in predisposing to the condition and/or lead to better understanding of the pathogenesis of the condition. This is achieved by investigating for associations between oestrogen receptor genetic variants and perinatal depression.

Conditions

Postnatal Depression; Genetic Predisposition

Outcome Measures

Primary Outcomes (1)

• Perinatal depression

  Defined as meeting Diagnostic and Statistical Manual for Psychiatric Disorders, Fourth Edition (DSM-IV) criteria for major depression through an interview by a clinician using Structured Clinical Interview for Diagnosis (SCID).

  Antenatal and postnatal period

Study Arms (2)

Cases: Perinatal depression

Cases will be defined as those with a depressive episode with onset during the antenatal or postnatal period.

Controls: No perinatal depression

Controls will be defined as those who score \< 7 on Edinburgh Postnatal Depression Scale and/or no episode of clinical depression from pregnancy until 6 months postnatal.

Eligibility Criteria

• Age: 21 Years - 35 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Chinese women attending antenatal and postnatal clinics in KK Women's and Children's Hospital and National University Hospital, Singapore.

You may qualify if:

• Anthropometric profile: age 21-35 years; Chinese race; Chinese ancestry for all 4 grandparents
• Natural conception (not artificially assisted)
• Cases: depressive episode during antenatal period or \< 6 months postnatal at time of recruitment; patients with past diagnosis of depression must have been well for 3 months before pregnancy
• Controls: well during antenatal period or \> 6 months postnatal at time of recruitment; no family history of depression or affective disorders

You may not qualify if:

• Other psychiatric disorders (non-mood disorders) namely schizophrenia and substance dependence
• Previously diagnosed neurological disorders

Sponsors & Collaborators

• KK Women's and Children's Hospital: lead
• National University Hospital, Singapore: collaborator

Study Sites (1)

KK Women's and Children's Hospital

Singapore, 229899, Singapore

Location

Biospecimen

Retention: SAMPLES WITH DNA

Saliva samples for DNA extraction

MeSH Terms

Conditions

Depression, Postpartum; Genetic Predisposition to Disease

Condition Hierarchy (Ancestors)

Puerperal Disorders; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Depressive Disorder; Mood Disorders; Mental Disorders; Disease Susceptibility; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Ene Choo Tan, Ph.D.

  KK Research Centre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 22, 2015
• First Posted: February 27, 2015
• Study Start: October 1, 2010
• Primary Completion (Estimated): December 1, 2028
• Study Completion (Estimated): December 1, 2028
• Last Updated: November 26, 2024

Record last verified: 2024-11

Locations

SG (1)