Cyclosporine A in the TReatment of Interstitial Pneumonitis Associated With Sjogren's Syndrome

NCT02370550 | Unknown Phase 4 DMC

• 3 other identifiers: 2014-M03U1111-1167-1974ChiCTR-IPR-15005990
• Study Type: interventional
• Target: 240
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this large multicenter, randomized, double-blinded, controlled clinical study is to investigate the efficacy and safety of Cyclosporin A for primary Sjogren's syndrome associated pneumonitis(pSS-IP), which has important implications for the establishment of standardized diagnosis and treatment of pSS-IP.

Conditions

Sjogren's Syndrome

Outcome Measures

Primary Outcomes (1)

• The forced vital capacity (FVC)

  The FVC is expressed as percent of expected values corrected baseline level.

  the 52 weeks

Secondary Outcomes (1)

• The diffusing capacity of carbon monoxide (DLco)

  the 52 weeks

Study Arms (2)

Cyclosporin A(CsA)+glucocorticoid

EXPERIMENTAL

A. The efficacy/safety are evaluated at V3, V4, V5 and V6, and the treatment is adjusted accordingly. Patients who experienced treatment failure (FVC absolute decrease \>15% of predicted values after 4 weeks of treatment) are suggested to switch to intravenous glucocorticoid + cyclophosphamide(CYC) 0.5-1 g/m2 every 4 weeks as the rescue therapy after unblinding, and continue to complete the subsequent follow-up. Each patient can only have one chance to be rescued. Patients who experience a second treatment failure should be withdrawn from the trial and be given empirical treatment. Patients who did not experience treatment failure continued to receive current treatment. B. For subjects with aggravated shortness of breath and dyspnea in between of two consecutive visits, the investigators should decide whether a visit should be increased to complete subsequent examinations.

Drug: Cyclosporin A; Drug: Prednisone; Drug: Calcium carbonate D

placebo+glucocorticoid

PLACEBO COMPARATOR

A. The efficacy/safety are evaluated at V3, V4, V5 and V6, and the treatment is adjusted accordingly. Patients who experienced treatment failure are suggested to switch to glucocorticoid + CsA 2-3mg/kg/d, BID as the rescue therapy, and continue to complete the subsequent follow-up. Each patient can only have one chance to be rescued. Patients who did not experience treatment failure continued to receive current treatment. B. For subjects with aggravated shortness of breath and dyspnea in between of two consecutive visits, the investigators in each center should decide whether a visit should be increased.

Drug: Prednisone; Drug: Placebo; Drug: Calcium carbonate D

Interventions

Cyclosporin A DRUG

CsA 2-3 mg/kg/d, BID PO

Also known as: Cyclosporin A Capsules, CsA soft capsules 25 mg, Hangzhou China-US East China pharmaceutical Co., Ltd.

Cyclosporin A(CsA)+glucocorticoid

Prednisone DRUG

Prednisone 0.5mg/kg/d QD PO starting at Week 0. After 2-4 weeks, the initial dose is gradually tapered by 2.5 mg each week until a maintenance dosage of 5-7.5 mg/d through week 52 (visit 6). The initial and maintenance doses are determined by the investigators of each center depending on the patients.

Cyclosporin A(CsA)+glucocorticoid; placebo+glucocorticoid

Placebo DRUG

Placebo tablet 2-3 mg/kg/d, BID PO

placebo+glucocorticoid

Calcium carbonate D DRUG

Calcium carbonate D 600 mg, QD PO

Cyclosporin A(CsA)+glucocorticoid; placebo+glucocorticoid

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients meeting the 2002 or 2012 pSS criteria;
• Patients meeting the diagnostic criteria of interstitial pneumonitis(IP);
• Patients with exertional dyspnea consistent with grade 2 on the Magnitude of Task component of the Mahler Modified Dyspnea Index;
• Pulmonary function test: patients with percentages of forced vital capacity (FVC) to predicted values≥45%, percentage of diffusing capacity of carbon monoxide (DLco) to predicted values≥30%, forced expiratory volume in one second (FEV1) / FVC\> 65%;
• For patients who received oral glucocorticoid, the doses should be no more than 10 mg/d (or equivalent amount of other types of glucocorticoids);
• Patients who had not received any prior treatment with immunosuppressants (including but not limited to CYC, CsA, azathioprine(AZA), tacrolimus(FK-506), methotrexate, leflunomide, etc.) or had discontinued the therapy above for at least 3 months; for patients who received hydrochloroquine(HCQ), the doses should be stabilized for at least 3 months;
• Patients who had not received any prior treatment with biological agents, including but not limited to rituximab, infliximab, adalimumab, etanercept, etc., or had discontinued therapy for at least three months;
• For patients who had prior treatment with N-acetylcysteine, the doses of above drugs should be stabilized for at least 3 months;
• The women of reproductive age who had a negative urine pregnancy test. The women and men of reproductive age must receive effective contraceptive measures from the screening period to last administration of drugs;
• Patients who were able to read, to understand and to sign informed consent.

You may not qualify if:

• Patients with acute exacerbation of IP(AEIP);
• Arterial blood gas analysis showed respiratory failure;
• Patients with lung diseases other than IP:
• Patients with severe pulmonary hypertension who require specific treatments assessed by the rheumatology and immunology experts in various clinical centers;
• Patients with a history of smoking within the last 6 months or current smokers;
• Patients with other serious lung diseases, such as lung tumor or active pulmonary infection;
• Lung biopsy, alveolar lavage or high-resolution computerized tomography (HRCT) suggested serious lung diseases other than IP;
• Patients with other rheumatic autoimmune diseases, including but not limited to rheumatoid arthritis, systemic lupus erythematosus, inflammatory myopathy, systemic sclerosis, primary biliary cirrhosis, etc.;
• Patients with serious heart, liver, kidney diseases, hematologic and/ or endocrine diseases:
• Heart diseases: decompensated heart failure or refractory hypertension; clinically important abnormal ECG that may lead to unacceptable risks to enrolled patients at screening;
• Liver function: alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) ≥2 times the upper limit of normal (ULN);
• Renal function: renal tubular and/or interstitial diseases, renal insufficiency: serum creatinine≥2 ULN or glomerular filtration rate (eGFR) \<90 ml/min/1.73 m2;
• White blood cell (WBC) count \<3 ×109/L and/or hemoglobin (Hb) \<100 g/L and/or platelet (PLT) count \<80×109 /L;
• Other serious diseases: such as cancer, etc.;
• Patients with active infection or other diseases which will be aggravated with treatment of glucocorticoid and immunosuppressive therapy;

Sponsors & Collaborators

• Peking University People's Hospital: lead

Study Sites (1)

Peking University People's Hospital

Beijing, Beijing Municipality, 110044, China

RECRUITING

MeSH Terms

Conditions

Sjogren's Syndrome

Interventions

Cyclosporine; Long-Term Synaptic Depression; Prednisone

Condition Hierarchy (Ancestors)

Arthritis, Rheumatoid; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Xerostomia; Salivary Gland Diseases; Mouth Diseases; Stomatognathic Diseases; Dry Eye Syndromes; Lacrimal Apparatus Diseases; Eye Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Intervention Hierarchy (Ancestors)

Cyclosporins; Peptides, Cyclic; Macrocyclic Compounds; Polycyclic Compounds; Peptides; Amino Acids, Peptides, and Proteins; Neuronal Plasticity; Nervous System Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Pregnadienediols; Pregnadienes; Pregnanes; Steroids; Fused-Ring Compounds

Study Officials

• Zhanguo Li, MD

  Peking University People's Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yue Yang, MD

CONTACT

+86-10-88325230

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Medicine

Study Record Dates

• First Submitted: February 18, 2015
• First Posted: February 25, 2015
• Study Start: March 1, 2015
• Primary Completion: March 1, 2021
• Study Completion: December 1, 2021
• Last Updated: May 22, 2020

Record last verified: 2020-05

Locations

CN (1)