Brasília Study on Healthy Aging

NCT02366104 | Completed

• 1 other identifier: Gerus
• Study Type: observational
• Target: 230
• Locations: 1 country
• Sites: 2

Brief Summary

BSHA is a cohort study of healthy elderlies enrolled voluntarily. It has been ongoing since December 2008. And the purpose of this study is to assess clinical and biological markers of cardiovascular risk in very elderly participants.

Conditions

Healthy

Keywords

Cardiovascular Diseases; Aged; Primary Prevention

Outcome Measures

Primary Outcomes (1)

• All cause mortality

  1 year

Secondary Outcomes (1)

• Major cardiovascular events

  2 years

Eligibility Criteria

• Age: 80 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Non-institutionalized outpatients under preventive care were voluntarily enrolled into the study. Participants were aged of 80 years or over, have never manifested myocardial infarction, stroke or peripheral arterial disease.

You may qualify if:

• Aged of 80 years or over

You may not qualify if:

• Manifested atherosclerotic disease (MI, stroke or peripheral arterial disease) according to medical evaluation, electrocardiogram and echocardiogram
• Functional dependence or institutionalization
• Cognitive impairment assessed by mini-mental state examination (\< 13 points)
• Use of any anti-inflammatory in the last 30 days
• Current or previous diagnosis of neoplastic or immune inflammatory disease
• Chronic obstructive pulmonary disease
• Glomerular filtration rate \< 25 mL/min/1.73 m2
• Hepatic disease (ALT or AST ≥ 1.5 upper reference limit)
• Chronic infectious disease (≥ 3 months)
• Left ventricular ejection fraction \< 50% on echocardiography
• Manifested neoplasia at admission or until the first year after enrollment

Sponsors & Collaborators

• University of Campinas, Brazil: lead
• Instituto de Cardiologia Biocardios: collaborator
• University of Brasilia: collaborator

Study Sites (2)

Biocárdios - Instituto de Cardiologia

Brasília, Federal District, Brazil

Location

University of Campinas

Campinas, São Paulo, 13083-887, Brazil

Location

Related Publications (6)

• Freitas WM, Quaglia LA, Santos SN, de Paula RC, Santos RD, Blaha M, Rivera JJ, Cury R, Blumenthal R, Nadruz-Junior W, Agatston A, Figueiredo VN, Nasir K, Sposito AC; Brazilian Study on Healthy Aging. Low HDL cholesterol but not high LDL cholesterol is independently associated with subclinical coronary atherosclerosis in healthy octogenarians. Aging Clin Exp Res. 2015 Feb;27(1):61-7. doi: 10.1007/s40520-014-0249-4. Epub 2014 Jun 7.

  PMID: 24906678 BACKGROUND

• Henriques AD, Tonet-Furioso AC, Machado-Silva W, Freitas WM, Quaglia LA, Santos SN, Cordova C, Sposito AC, Nobrega OT; Brazilian Study on Healthy Aging Group. Apoliprotein E genotype is associated with apoliprotein B plasma levels but not with coronary calcium score in very elderly individuals in primary care setting. Gene. 2014 Apr 15;539(2):275-8. doi: 10.1016/j.gene.2014.01.077. Epub 2014 Feb 12.

  PMID: 24530308 BACKGROUND

• Souza VC, Freitas WM, Quaglia LA, Santos SN, Cordova C, Sposito AC, Nobrega OT. Osteopontin in bone mineral density of very old Brazilians. J Bone Miner Metab. 2013 Jul;31(4):449-54. doi: 10.1007/s00774-013-0425-1. Epub 2013 Mar 21.

  PMID: 23515922 BACKGROUND

• Costa AP, de Paula RC, Carvalho GF, Araujo JP, Andrade JM, de Almeida OL, de Faria EC, Freitas WM, Coelho OR, Ramires JA, Quinaglia e Silva JC, Sposito AC; Brasilia Heart Study Group. High sodium intake adversely affects oxidative-inflammatory response, cardiac remodelling and mortality after myocardial infarction. Atherosclerosis. 2012 May;222(1):284-91. doi: 10.1016/j.atherosclerosis.2012.02.037. Epub 2012 Mar 3.

  PMID: 22436606 BACKGROUND

• Freitas WM, Quaglia LA, Santos SN, Soares AA, Japiassu AV, Boaventura V, dos Santos Barros E, Cordova C, Nobrega OT, Sposito AC. Association of systemic inflammatory activity with coronary and carotid atherosclerosis in the very elderly. Atherosclerosis. 2011 May;216(1):212-6. doi: 10.1016/j.atherosclerosis.2011.01.040. Epub 2011 Feb 2.

  PMID: 21316055 BACKGROUND

• de Azevedo Filho ER, Koeche C, Bueno FF, de Toledo O, Alves VP, da Silva HS, Moraes CF, Freitas WM, Campos-Staffico AM, de Carvalho LSF. Unraveling the intertwined threads of insomnia and sarcopenia in cognitive and functional impairment in octogenarians. BMC Geriatr. 2025 Nov 7;25(1):868. doi: 10.1186/s12877-025-06398-3.

  PMID: 41204176 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Plasma Leukocyte DNA

MeSH Terms

Conditions

Cardiovascular Diseases

Study Officials

• Andrei C Sposito, Ph.D.

  University of Campinas

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D., Ph.D.

Study Record Dates

• First Submitted: February 11, 2015
• First Posted: February 19, 2015
• Study Start: December 1, 2008
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2016
• Last Updated: March 25, 2019

Record last verified: 2019-03

Locations

BR (2)