ADHD: Gaps Between Patients With Alcohol-dependence and Impact on Relapse

NCT02364817 | Completed

• 2 other identifiers: 2013_092014-A00132-45
• Study Type: observational
• Target: 113
• Locations: 1 country
• Sites: 3

Brief Summary

Some recent studies have found that adult attention deficit - hyperactivity disorder (ADHD) was frequent among patients with alcohol-dependence. However, no investigation has ever addressed whether ADHD may impact the drinking outcome. Moreover, most of the different aforementioned studies assessed ADHD using the ADHD self-report scale (ASRS). The ASRS is a screening questionnaire that is of limited diagnostic value, and the overrepresentation of high-score ASRS among patients with alcohol-dependence could be in part due to differential diagnoses such as antisocial or borderline personality disorders, executive function impairments, or isolated impulsiveness. The study aims to evaluate "ADHD: Gaps between patients with Alcohol Dependence and Impact on early Relapse" (AGADIR). In AGADIR, subjects with alcohol-dependence are recruited at the end of a residential detoxification program. They are assessed for ADHD using the ASRS, but also with a standardized diagnostic tool, i.e., the Diagnostic Interview for ADHD in adults (DIVA 2.0). Potential differential diagnoses are screened during the baseline visit. The patients are followed-up during the 12 first post-detox weeks, through a standardized psychosocial treatment. ASRS is re-performed at the end of the follow-up.

Conditions

Alcoholism; Attention Deficit Disorder With Hyperactivity

Keywords

Attention Deficit Disorder with Hyperactivity; Alcohol Dependence; Adults; Treatment outcome; Mental Health

Outcome Measures

Primary Outcomes (1)

• Cumulated rate of alcohol relapse

  Cumulated rate of alcohol relapse during the 12 weeks following the detoxification program

  12 weeks

Secondary Outcomes (2)

• Psychometric properties of the ASRS

  12 weeks

• Multivariate analysis of the alcohol relapse

  12 weeks

Study Arms (1)

Post-Detox Cohort

All the patients included should meet Diagnostic and Statistical Manual 4th edition revised (DSM-IV-Tr) criteria for Alcohol Dependance. They are all recruited at the end of an inpatient alcohol detoxification process (see inclusion criteria). The initial screening is performed just before the end of hospitalization. The subsequent follow-up is 12 weeks-long. There is no drug for abstinence maintenance during the study. The psychosocial intervention is based on the BRENDA model.

Behavioral: cognitive and psychiatric assessment

Interventions

cognitive and psychiatric assessment BEHAVIORAL

Administered at baseline: * Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) * hyperactivity : Adult ADHD Self-Report Scale (ASRS), Wenders-Utah Rating Scale (WURS), Diagnostic Interview for Adult ADHD 2nd edition (DIVA 2.0) * psychiatric history : Mini International Neuropsychiatric Interview 5th edition (MINI 5.0), Personality Disorder Questionnaire for the DSM-IV (PDQ-4) * cognitive functions : Frontal Assessment Battery (FAB), Montreal Cognitive Assessment (MoCA) * impulsivity : Barratt's Impulsiveness scale 11th edition (BIS-11) * alcohol consumption: alcohol - timeline follow-back (A-TLFB) ,administered at baseline (month before hospitalization), week 4 visit, week 6 visit, and week 12 visit. * administered at week 12: ASRS

Post-Detox Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects with alcohol-dependence who undergo a residential alcohol detoxification program

You may qualify if:

• current DSM-IV-Tr criteria for alcohol-dependence
• current residential alcohol detoxification program
• concurrent alcohol withdrawal symptoms, i.e., CIWA-Ar ≥ 10
• benzodiazepine diazepam-equivalent dose \> 30 mg
• medical history of neurological impairment (excluding alcohol-induced cognitive disorders)
• guardianship or loss of liberty
• pregnant or lactating woman

Sponsors & Collaborators

• University Hospital, Lille: lead
• Institute for Scientific Research on Beverages (France): collaborator

Study Sites (3)

Ch Le Vinatier

Bron, France

Location

Department of Addiction Medicine

Lille, 59037, France

Location

Department of Addiction Medicine

Saint-Amand-les-Eaux, 59230, France

Location

MeSH Terms

Conditions

Alcoholism; Attention Deficit Disorder with Hyperactivity; Psychological Well-Being

Condition Hierarchy (Ancestors)

Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders; Attention Deficit and Disruptive Behavior Disorders; Neurodevelopmental Disorders; Personal Satisfaction; Behavior

Study Officials

• Renaud Jardri, MD, PhD

  University Hospital of Lille (CHU Lille), France

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2015
• First Posted: February 18, 2015
• Study Start: January 1, 2015
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2017
• Last Updated: December 16, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (3)