Optimisation and Quantification of Contrast Enhanced Computed Tomography Myocardial Fibrosis Imaging

NCT02364687 | Completed

• 1 other identifier: 13/SS/0152
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

Detecting scarred heart muscle is important to diagnose and treat of a wide variety of heart conditions. Magnetic resonance imaging (MRI) can assess scarred heart muscle but it is time consuming, contraindicated for some patients and not tolerated by others. Computed tomography (CT) imaging has the potential to provide a rapid comprehensive assessment of the heart. This study will assess CT imaging of the heart muscle of patients who have previously undergone MRI of their heart. Using a state of the art CT scanner the investigators will develop a low radiation dose protocol to identify scarred heart muscle. The investigators will use and develop software techniques to analyse these images. This will enable us to develop a new way to identify and measure scarred heart muscle that will benefit patients with heart disease.

Conditions

Myocardial Infarction

Outcome Measures

Primary Outcomes (1)

• Myocardial late enhancement

  The amount of myocardial late enhancement measured on computed tomography as compared to magnetic resonance imaging.

  Immediate

Study Arms (1)

Participants

Participants will have previously had an MRI scan and will undergo a CT scan.

Radiation: Computed tomography late enhancement imaging

Interventions

Computed tomography late enhancement imaging RADIATION

Participants

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who have previously undergone magnetic resonance imaging which showed myocardial late enhancement.

You may qualify if:

• Presence of late enhancement on magnetic resonance imaging

You may not qualify if:

• age less than 40
• inability or unwillingness to undergo CT
• renal failure (serum creatinine \>200 umol/l or estimated glomerular filtration rate \<30 ml/min)
• hepatic failure
• allergy to iodinated contrast
• pregnancy
• breast feeding
• inability to undergo informed consent
• fast atrial fibrillation

Sponsors & Collaborators

• University of Edinburgh: lead

MeSH Terms

Conditions

Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Michelle Williams

  University of Edinburgh, NHS Lothian

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2015
• First Posted: February 18, 2015
• Study Start: October 1, 2013
• Primary Completion: December 1, 2015
• Study Completion: May 1, 2023
• Last Updated: June 27, 2023

Record last verified: 2022-06