NCT02364050

Brief Summary

Prospective data collection of a consecutive series of elderly patients with large B-cell lymphoma newly diagnosed, receiving before the start of treatment Multidimensional Geriatric Assessment (VGM) through the use of Activity of Daily Living (ADL), Instrumental Activity of Daily Living (IADL) and Cumulative Illness Rating Scale for Geriatrics (CIRS-G).

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
1,300

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Sep 2013

Longer than P75 for all trials

Geographic Reach
1 country

55 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2013

Completed
1.4 years until next milestone

First Submitted

Initial submission to the registry

February 10, 2015

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 16, 2015

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2017

Completed
3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2020

Completed
Last Updated

February 6, 2020

Status Verified

February 1, 2020

Enrollment Period

4.3 years

First QC Date

February 10, 2015

Last Update Submit

February 5, 2020

Conditions

Outcome Measures

Primary Outcomes (1)

  • OS

    Overall survival

    5 years

Secondary Outcomes (5)

  • PFS

    5 years

  • FFS

    5 years

  • Response to initial therapy

    5 years

  • Early mortality rate

    5 years

  • % of patients who performed pre-phase therapy

    5 years

Study Arms (1)

Elderly patients with DLBCL

Elderly patients (Age ≥ 65 years) with large B-cell lymphoma classified FIT or UNFIT or FRAIL by Multidimensional Geriatric Assessment (MGA)

Eligibility Criteria

Age65 Years+
Sexall
Healthy VolunteersNo
Age GroupsOlder Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Elderly patients with large B-cell lymphoma classified FIT or UNFIT or FRAIL by Multidimensional Geriatric Assessment (MGA)

You may qualify if:

  • Patient with Large B-cell Lymphoma
  • Age ≥ 65 years
  • informed Consent

You may not qualify if:

  • Abscence of data considered essential for the study
  • Withdrawal of Consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (55)

Azienda Ospedaliera Caravaggio

Treviglio, Bergamo, 24127, Italy

Location

A.O.Cardinale Panico Ematologia e centro trapianti

Tricase, LE, Italy

Location

IRCCS Humanitas

Rozzano, Milano, 20089, Italy

Location

CRO-Centro di Riferimento Oncologico

Aviano, Pordenone, 33081, Italy

Location

CROB

Rionero in Vulture, Potenza, 85028, Italy

Location

Polo Pontino

Latina, Roma, 04100, Italy

Location

ASL TO-4

Ivrea, Torino, 10015, Italy

Location

Ospedale S. Giacomo di Castelfranco Veneto

Castelfranco Veneto, Treviso, 31033, Italy

Location

AO SS.Antonio e Biagio

Alessandria, 15121, Italy

Location

AOU Ospedali Riuniti

Ancona, 60126, Italy

Location

A.O. Universitaria Ospedale Consorziale Policlinico Di Bari

Bari, 70124, Italy

Location

IRCC Istituto tumori Ematologia

Bari, Italy

Location

AO Barletta

Barletta, 76121, Italy

Location

SOS Ematologia Divisione Medicina Interna Ospedale degli Infermi

Biella, Italy

Location

Spedali Civili di Brescia

Brescia, 25123, Italy

Location

Ospedale Businco

Cagliari, 09121, Italy

Location

Arnas Garibaldi

Catania, Italy

Location

AO di Cosenza

Cosenza, Italy

Location

AO Santa Croce e Carle

Cuneo, 12100, Italy

Location

AOU Careggi

Florence, 50134, Italy

Location

Ematologia Ospedale Vito Fazzi

Lecce, Italy

Location

USL 6 Livorno Centro Aziendale Ematologia

Livorno, 57124, Italy

Location

Ospedale di Matera

Matera, 75100, Italy

Location

Area Vasta Romagna e IRST

Meldola (FC), Italy

Location

Ospedali Riuniti Papardo

Messina, 98158, Italy

Location

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Milan, 20122, Italy

Location

Ospedale S. Raffaele

Milan, 20132, Italy

Location

Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, 20133, Italy

Location

AO Niguarda

Milan, 20162, Italy

Location

Osp. San Carlo Borromeo Divisione di Oncologia Medica

Milan, Italy

Location

AOU Policlinico di Modena

Modena, 41124, Italy

Location

Ospedale San Gerardo

Monza, Italy

Location

AUO Maggiore della Carità

Novara, 28100, Italy

Location

Istituto Oncologico Veneto

Padua, 35128, Italy

Location

AOU Padova

Padua, Italy

Location

A.O. Universitaria Policlinico Giaccone Di Palermo

Palermo, 90127, Italy

Location

A.O. Ospedali Riuniti Villa Sofia-Cervello

Palermo, Italy

Location

Azienda Ospedaliero-Universitaria di Parma

Parma, 43126, Italy

Location

Fondazione IRCCS Policlinico S.Matteo

Pavia, 27100, Italy

Location

AO di Perugia S. Maria della misericordia

Perugia, 06132, Italy

Location

Ospedale di Pescara

Pescara, 65124, Italy

Location

Ospedale Civile di Piacenza

Piacenza, 29121, Italy

Location

Ospedale S. Maria delle Croci

Ravenna, Italy

Location

A.O. Bianchi Melacrino Morelli

Reggio Calabria, Italy

Location

AO Santa Maria Nuova

Reggio Emilia, 42123, Italy

Location

Ospedale degli Infermi

Rimini, 47923, Italy

Location

AOU La Sapienza

Roma, 00161, Italy

Location

Policlinico Universitario A.Gemelli

Roma, 00168, Italy

Location

Azienda OSpedaliera S. Andrea

Roma, 00189, Italy

Location

AOU Senese

Siena, 53100, Italy

Location

AO Santa Maria di Terni

Terni, 05100, Italy

Location

AO Città della Salute e della Scienza Ematologia Universitaria

Torino, 10126, Italy

Location

AO Città della Salute e della Scienza SC Ematologia

Torino, 10126, Italy

Location

Ospedale di Circolo

Varese, Italy

Location

Presidio Ospedaliero S. Andrea

Vercelli, 13100, Italy

Location

Related Publications (1)

  • Merli F, Luminari S, Tucci A, Arcari A, Rigacci L, Hawkes E, Chiattone CS, Cavallo F, Cabras G, Alvarez I, Fabbri A, Re A, Puccini B, Barraclough A, Delamain MT, Ferrero S, Usai SV, Ferrari A, Cencini E, Pennese E, Zilioli VR, Marino D, Balzarotti M, Cox MC, Zanni M, Di Rocco A, Lleshi A, Botto B, Hohaus S, Merli M, Sartori R, Gini G, Nassi L, Musuraca G, Tani M, Bottelli C, Kovalchuk S, Re F, Flenghi L, Molinari A, Tarantini G, Chimienti E, Marcheselli L, Mammi C, Spina M. Simplified Geriatric Assessment in Older Patients With Diffuse Large B-Cell Lymphoma: The Prospective Elderly Project of the Fondazione Italiana Linfomi. J Clin Oncol. 2021 Apr 10;39(11):1214-1222. doi: 10.1200/JCO.20.02465. Epub 2021 Feb 12.

MeSH Terms

Conditions

Lymphoma, Large B-Cell, Diffuse

Condition Hierarchy (Ancestors)

Lymphoma, B-CellLymphoma, Non-HodgkinLymphomaNeoplasms by Histologic TypeNeoplasmsLymphoproliferative DisordersLymphatic DiseasesHemic and Lymphatic DiseasesImmunoproliferative DisordersImmune System Diseases

Study Officials

  • Michele Spina, MD

    CRO-Centro di Riferimento Oncologico

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 10, 2015

First Posted

February 16, 2015

Study Start

September 1, 2013

Primary Completion

December 1, 2017

Study Completion

December 1, 2020

Last Updated

February 6, 2020

Record last verified: 2020-02

Data Sharing

IPD Sharing
Will share

Locations