Outcomes Following Total Knee Arthroplasty

NCT02364011 | Completed DMC

• 1 other identifier: 75446
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this investigation is to determine both patient-reported and performance-based outcomes, specifically muscle function and kinematic/kinetic outcomes, between four different surgical total knee prostheses in individuals following TKA. Change scores will be determined based on patient-reported outcomes, kinematic/kinetic data, knee extension strength/power, static/dynamic balance control, mobility measures and functional performance testing during functional tasks (i.e. walking, ascending/descending stairs, sit-to-stand). After evaluating the pattern of change in lower-extremity function, the investigators will be better prepared to address residual functional impairments and prognostic factors linked to maximal recovery over two years.

Conditions

Osteoarthritis

Keywords

Biomechanics; Primary Total Knee Arthroplasty; TKA Bearings; Osteoarthritis; Total Knee Replacement

Outcome Measures

Primary Outcomes (1)

• Patient Reported Outcome Scores following TKA

  Follow Up Visits up to 2-Years

Eligibility Criteria

• Age: 40 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who present to the University of Utah for TKA surgical procedure

You may qualify if:

• adults \> 40 years of age that are scheduled for primary TKA
• if they have had a previous TKA, it needs to have been performed on the opposite leg at least 3 months prior to the current TKA
• willing to return for follow-up visits and should be willing and able to be transported from the UOC to the Skeletal Muscle Exercise Research Facility (SMERF), in the Department of Physical Therapy study site for scheduled research follow-up appointments

You may not qualify if:

• adult with previous additional orthopaedic, neurological, visual or surgical conditions that may affect gait or balance

Sponsors & Collaborators

• University of Utah: lead

Study Sites (1)

University of Utah Orthopaedic Center

Salt Lake City, Utah, 84108, United States

Location

MeSH Terms

Conditions

Osteoarthritis

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Christopher Pelt, MD

  University of Utah

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Study Record Dates

• First Submitted: February 9, 2015
• First Posted: February 16, 2015
• Study Start: November 1, 2014
• Primary Completion: June 10, 2025
• Study Completion: June 10, 2025
• Last Updated: November 18, 2025

Record last verified: 2025-11

Locations

US (1)