The Effects of Morphine on Desflurane Consumption and Recovery Time
Comparison of Two Different Doses of Intravenous Morphine on Desflurane Consumption and Recovery Time in Patients Undergoing Total Abdominal Hysterectomy
1 other identifier
interventional
90
1 country
1
Brief Summary
Combination of volatile and opioid agents are used to achieve unconsciousness, haemodynamic stability and analgesia for surgical prosedures. This prospective, randomized, double-blind, controlled study evaluates the effects of two different doses of morphine sulphate (0.1 mg/kg and 0.2 mg/kg), on desflurane consumption, recovery characteristics, postoperative analgesic requirements and side effects during total abdominal hysterectomy.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_4
Started Sep 2007
Shorter than P25 for phase_4
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2007
CompletedFirst Submitted
Initial submission to the registry
February 4, 2015
CompletedFirst Posted
Study publicly available on registry
February 12, 2015
CompletedDecember 3, 2015
June 1, 2015
3 months
February 4, 2015
December 2, 2015
Conditions
Outcome Measures
Primary Outcomes (2)
postoperative desflurane consumption
postoperative first hour
sedation scores for OASS scale
postoperative first hour
Study Arms (3)
Group Saline
PLACEBO COMPARATORGroup Saline (Group S) received i.v saline 0.9 % in 10 ml volume (n=30)
Group Morphine 1
ACTIVE COMPARATORGroup Morphine 1 (Group M1) received i.v morphine 0.1 mg kg-1, in 10 ml volume (n=30)
Group Morphine 2
ACTIVE COMPARATORGroup Morphine 2 (Group M2) received i.v morphine 0.2 mg kg-1, in 10 ml volume (n=30)
Interventions
Group Saline (Group S): Received i.v saline 0.9 % in 10 ml volume (n=30) Group Morphine 1 (Group M1): Received i.v morphine 0.1 mg kg-1 in 10 ml volume (n=30) Group Morphine 2 (Group M2): Received i.v morphine 0.2 mg kg-1 in 10 ml volume (n=30)
Eligibility Criteria
You may qualify if:
- undergoing total abdominal hysterectomy with general anaesthesia
You may not qualify if:
- renal dysfunction (cre\>1.2), liver failure, cardiovascular, psychiatric, allergic and metabolic disorders
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Baskent University School of Medicine Adana Teaching and Research Hospital
Adana, 01250, Turkey (Türkiye)
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
cagla bali
Baskent University
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- CARE PROVIDER, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- medical doctor
Study Record Dates
First Submitted
February 4, 2015
First Posted
February 12, 2015
Study Start
September 1, 2007
Primary Completion
December 1, 2007
Study Completion
December 1, 2007
Last Updated
December 3, 2015
Record last verified: 2015-06