Role of Oxytocin in Telling and Detecting Lies

NCT02361177 | Withdrawn Early Phase 1

• 1 other identifier: 2013-11-0033
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

The investigators are interested in the impact of intranasal oxytocin in unethical behavior.

Conditions

Dyssocial Behavior

Outcome Measures

Primary Outcomes (1)

• Unethical behavior

  To measure unethical behavior, we will calculate whether participants took more money than they actually earned on a problem-solving task.

  130 minutes

Study Arms (2)

oxytocin

EXPERIMENTAL

Intranasal 24 IU oxytocin self-administration.

Drug: Oxytocin

placebo

PLACEBO COMPARATOR

Intranasal placebo. 125 mg of 0.5% cholorobutanol to 50 ml saline, with approximately 5 pH. The solution will then be sterilized using a 0.22 micron filter.

Drug: Oxytocin

Interventions

Oxytocin DRUG

Intranasal oxytocin is hypothesized to amplify the influence of social norms on unethical behavior.

Also known as: syntocinon

oxytocin; placebo

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male

You may not qualify if:

• \_\_\_\_\_ \_\_\_\_\_BP \> 130/85, HRT \> 95 (can be included at discretion of study physician/designee)
• \_\_\_\_\_History of seizures
• \_\_\_\_\_Neurological Disorder
• \_\_\_\_\_Current psychiatric disorder
• \_\_\_\_\_Previous psychiatric disorder (can be included at discretion of PI)
• Date last episode (if \> 1 year, include; if \<1 year, at discretion of PI)
• \_\_\_\_\_Current use of psychoactive drugs
• \_\_\_\_\_Previous use of psychoactive drugs (can be included at discretion of PI) \_\_\_\_\_Date last medicated\_\_\_\_\_ \_\_\_\_\_Type of medication\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
• \_\_\_\_\_Current use of anticoagulants
• \_\_\_\_\_Current use of corticosteroids
• \_\_\_\_\_Previous head trauma (can be included at discretion of PI)
• \_\_\_\_\_Alcoholism or substance abuse
• \_\_\_\_\_Carcinoma of the breast or prostate
• \_\_\_\_\_Renal or Hepatic diseases
• \_\_\_\_\_Chronic lung diseases

Sponsors & Collaborators

• University of Texas at Austin: lead
• Harvard University: collaborator

Related Publications (1)

• Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E. Oxytocin increases trust in humans. Nature. 2005 Jun 2;435(7042):673-6. doi: 10.1038/nature03701.

  PMID: 15931222 RESULT

MeSH Terms

Conditions

Antisocial Personality Disorder

Interventions

Oxytocin

Condition Hierarchy (Ancestors)

Personality Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Pituitary Hormones, Posterior; Pituitary Hormones; Peptide Hormones; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Peptides; Amino Acids, Peptides, and Proteins

Study Officials

• Robert A Josephs, PhD

  utaustin

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 5, 2015
• First Posted: February 11, 2015
• Study Start: January 1, 2016
• Primary Completion: April 1, 2016
• Study Completion: April 1, 2016
• Last Updated: June 13, 2016

Record last verified: 2016-06