Emergence From Anesthesia in Anterior Temporal Lobectomy and Amygdalohippocampectomy Patients

NCT02360098 | Completed Results

• 1 other identifier: UHN REB 14-8212 BE
• Study Type: observational
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

Smooth emergence (wake up) from anesthesia is an important consideration in patients undergoing neurosurgical procedures as blood pressure changes associated with violent emergence can cause intracranial hemorrhage and brain swelling. At the same time, emergence should also be quick so that patients' neurological function can be assessed at a timely manner. Pattern of emergence from anesthesia is poorly investigated and understood.

Conditions

Emergence From Anesthesia

Keywords

Emergence from Anesthesia; Anterior temporal lobectomy; Amygdalohippocampectomy; Anesthesia

Outcome Measures

Primary Outcomes (1)

• Volumes of the Hippocampus, Thalamus and Amygdala

  Comparison of volumes of the hippocampus, thalamus and amygdala between Agitated and Smooth emergence groups

  1 day

Interventions

Emergence from Anesthesia OTHER

There are no study related interventions in this study and perioperative care of these patients will be as per our standard practice The only study related protocol would be collecting the data on the emergence from anesthesia. The data will be collected from the time of turning off the anesthetic agents till the discharge from recovery room. Data collected include, vital signs, Glasgow coma scale( GCS), and Riker agitation- sedation score.. The patients will be assessed every 5 minutes for the first 30 minutes and every 10 minutes for the next 60 minutes.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Emergence from anesthesia in anterior temporal lobectomy and amygdalohippocampectomy PATIENTS

You may qualify if:

• Adult patients above the age of 18 who are scheduled for elective anterior temporal lobectomy and amygdalohippocampectomy under General Anesthesia

You may not qualify if:

• Lack of informed consent Patients needing intensive care unit postoperatively

Sponsors & Collaborators

• Lashmi Venkatraghavan: lead
• University Health Network, Toronto: collaborator

Study Sites (1)

Toronto Western Hospital

Toronto, Ontario, M5T2S8, Canada

Location

Results Point of Contact

• Title: Emad Al Azazi
• Organization: TORONTO WESTERN HOSPITAL/UHN

emad.alazazi@uhnresearch.ca

416-603-5800

Study Officials

• Lashmi Venkatraghavan, MD

  Toronto Western Hospital/UHN

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Professor, Department of Anesthesia, Toronto Western Hospital, Toronto, Canada

Study Record Dates

• First Submitted: February 2, 2015
• First Posted: February 10, 2015
• Study Start: December 1, 2014
• Primary Completion: March 1, 2017
• Study Completion: March 1, 2017
• Last Updated: July 13, 2020
• Results First Posted: July 13, 2020

Record last verified: 2020-07

Locations

CA (1)