Vitamin D Influence on Oocyte Donation
Impact of Vitamin D Levels on Ovarian Reserve and Ovarian Response to Controlled Stimulation in Egg Donors
1 other identifier
observational
269
0 countries
N/A
Brief Summary
Objective: To investigate the correlation between total and bioavailable serum 25-OH vitamin D, ovarian reserve and ovarian response to controlled stimulation in egg donors.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2013
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2013
CompletedFirst Submitted
Initial submission to the registry
November 7, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2015
CompletedFirst Posted
Study publicly available on registry
January 19, 2015
CompletedJanuary 19, 2015
January 1, 2015
1.5 years
November 7, 2014
January 16, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Numbers of oocytes retrieved
2 months
Secondary Outcomes (5)
implantation rate
2 months
pregnancy rate
2 months
AFC
2 months
number of mature oocytes
2 months
AMH
2 months
Interventions
observational study of 269 donnors
Eligibility Criteria
oocytes' donors who underwent ovarian stimulation cycles in our clinic from June 2013 to April 2014
You may qualify if:
- Caucasian race,
- between 18 and 34 years of age,
- all donors had normal menstrual cycles of 26-34 days,
- normal weight range (BMI 18- 25 Kg/m2),
- normal uterus and ovaries on transvaginal ultrasound (no signs of polycystic ovarian syndrome), and
- an antral follicle count (AFC) \>10,
- normal karyotype
You may not qualify if:
- current or past exposure to radiation or hazardous chemical substances,
- history of drug use,
- family history of hereditary chromosomal diseases,
- sexually transmitted diseases
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- IVI Madridlead
Related Publications (1)
Holick MF et al. Endocrine Society. Evaluation, treatment, prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911-1930 Rudick B et al. Characterizing the influence of vitamin D levels on IVF outcomes. Hum Reprod. 2012;27:3321-7 Polyzos NP et al. Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ICSI. Hum Reprod. 2014;29:2032-40 Franasiak JM et al. Vitamin D levels do not affect IVF outcomes following the transfer of euploid blastocysts. Am J Obstet Gynecol 2014;211:x.ex-x.ex Fabris A, Pacheco A, Cruz M, Puente JM, Fatemi H, Garcia-Velasco JA. Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients. Fertil Steril. 2014. Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril. 2014 ;102:460-468
RESULT
Study Officials
- PRINCIPAL INVESTIGATOR
Juan Antonio García Velasco, Professor
IVI Madrid
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 7, 2014
First Posted
January 19, 2015
Study Start
June 1, 2013
Primary Completion
December 1, 2014
Study Completion
January 1, 2015
Last Updated
January 19, 2015
Record last verified: 2015-01