Cancer Development In Organ Transplant Recipients

NCT02333279 | Completed DMC

• 2 other identifiers: FUP062snctp000000587
• Study Type: observational
• Target: 1,800
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators will determine the cancer risk in organ transplant recipients compared to the general population with the help of statistical analysis. Secondly the investigators will try to characterize the different cancer types.

Conditions

Heart Cancer; Kidney Cancer; Lung Cancer; Pancreas Cancer; Liver Cancer

Outcome Measures

Primary Outcomes (1)

• Number of solid cancers

  Number of solid cancers

  Ten Year followup

Study Arms (1)

Organ transplant recipients

Follow-ups in regular intervals following the organ transplant date.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All solid organ transplant recipients in Switzerland since 2008 who have given their consent to be included in the study.

You may qualify if:

• We will select all patients within the STCS based on the date of the first solid organ transplantation. Patients with multiple organ transplantations will be included as well. Patients contribute to the study observation time until death or end of follow-up due to other reasons.

You may not qualify if:

• We will exclude patients with non-solid organ transplantation (e.g. hematopoietic stem cell transplantation), because the detailing of information in the STCS is insufficient to allow for detailed analysis of cancer development and control of relevant confounders. We will exclude

Sponsors & Collaborators

• University of Zurich: lead
• University Hospital, Basel, Switzerland: collaborator
• Insel Gruppe AG, University Hospital Bern: collaborator
• Cantonal Hospital of St. Gallen: collaborator
• University Hospital, Geneva: collaborator
• University of Lausanne Hospitals: collaborator

Study Sites (1)

University Hospital Zurich, Division of Dermatology

Zurich, 8091, Switzerland

Location

Related Publications (1)

• Lengwiler E, Stampf S, Zippelius A, Salati E, Zaman K, Schafer N, Schardt J, Siano M, Hofbauer G, The Swiss Transplant Cohort Study. Solid cancer development in solid organ transplant recipients within the Swiss Transplant Cohort Study. Swiss Med Wkly. 2019 May 19;149:w20078. doi: 10.4414/smw.2019.20078. eCollection 2019 May 6.

  PMID: 31104307 RESULT

MeSH Terms

Conditions

Heart Neoplasms; Kidney Neoplasms; Lung Neoplasms; Pancreatic Neoplasms; Liver Neoplasms

Condition Hierarchy (Ancestors)

Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Heart Diseases; Cardiovascular Diseases; Urologic Neoplasms; Urogenital Neoplasms; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Kidney Diseases; Urologic Diseases; Male Urogenital Diseases; Respiratory Tract Neoplasms; Lung Diseases; Respiratory Tract Diseases; Digestive System Neoplasms; Endocrine Gland Neoplasms; Digestive System Diseases; Pancreatic Diseases; Endocrine System Diseases; Liver Diseases

Study Officials

• Gunther FL Hofbauer, MD

  University Hospital, Zürich

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 18, 2014
• First Posted: January 7, 2015
• Study Start: May 1, 2008
• Primary Completion: May 1, 2018
• Study Completion: July 1, 2019
• Last Updated: July 29, 2019

Record last verified: 2019-07

Locations

CH (1)