NCT02331082

Brief Summary

Globally, over seven million children under the age of five die each year, although a suite of interventions-safe delivery care, neonatal care and resuscitation, and management of childhood diarrhea, malnutrition, and pneumonia-can prevent many of these deaths when implemented within functioning health systems. This study will include a quasi experimental, stepped wedge, cluster-controlled trial of a mobile health care coordination and quality improvement intervention designed to facilitate comprehensive health systems strengthening. It will do this through training and equipping community-level health care clinics to manage chronic diseases through use of the Chronic Care Model, structured quality improvement sessions to promote clinical mentorship, and use of an integrated electronic medical record to provide real-time data for disease surveillance. The investigators hypothesize that improving upon the health system in these ways will lead to a 25% reduction in under-two mortality through improved services for the citizens of Achham, Nepal.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
7,000

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Nov 2014

Longer than P75 for not_applicable

Geographic Reach
1 country

2 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 8, 2013

Completed
1.2 years until next milestone

Study Start

First participant enrolled

November 1, 2014

Completed
2 months until next milestone

First Posted

Study publicly available on registry

January 6, 2015

Completed
4.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2019

Completed
Last Updated

December 6, 2017

Status Verified

December 1, 2017

Enrollment Period

4.9 years

First QC Date

August 8, 2013

Last Update Submit

December 4, 2017

Conditions

Keywords

Infant MortalityUnder-two mortalityMaternal MortalityImplementation ResearchHealth Systems StrengtheningChronic Disease ManagementCommuity Health Workers

Outcome Measures

Primary Outcomes (3)

  • Under-two mortality rate

    We expect the intervention will lead to a 25% decrease in under-two mortality in the experimental arm.

    Five years

  • Infant mortality rate

    We expect the intervention will lead to a 25% decrease in the infant mortality rate in the experimental arm.

    Five years

  • Neonatal mortality rate

    We expect the intervention will lead to a 25% decrease in the neonatal mortality rate in the experimental arm.

    Five years

Secondary Outcomes (6)

  • Institutional Birth Rate

    Five years

  • Antenatal Care Completion Percentage

    Five years

  • Postpartum contraceptive prevalence rate

    Five years

  • Preterm delivery rate

    Five years

  • Low birthweight delivery rates

    Five years

  • +1 more secondary outcomes

Study Arms (2)

Control

ACTIVE COMPARATOR

Existing healthcare system

Other: Existing healthcare system

Health System Improvement

EXPERIMENTAL

Structured Quality Improvement Chronic Care Model Integrated Electronic Medical Record Solar-powered electrical supply Performance-based financing

Other: Structured Quality ImprovementOther: Chronic Care ModelDevice: Integrated Electronic Medical RecordDevice: Solar-powered electrical supplyBehavioral: Performance-based financing

Interventions

For structured quality improvement, trained healthcare providers (primarily doctors from referral hospital) will serve as mentors to mid-level providers. The mentors will facilitate on-site trainings of primary care with mid-level providers at the district hospital. Mentors will also travel monthly to the healthcare facilities themselves to provide training both in the direct context of clinical care and to provide feedback based upon surveillance and monitoring data. The focus will be on the techniques from the Institute for Healthcare Improvement's Model for Improvement, including Plan-Do-Study-Act cycles, run charts, and root cause analyses. Finally, they will work with the clinical healthcare staff to identify resource needs from the local government for maintenance, water, electricity, and supplies. These resource needs will be addressed through an integrated supply chain management system across the tiers of the healthcare system.

Also known as: Clincal Mentorship, Supply Chain Management
Health System Improvement

Senior physicians trained in mentorship of non-physician mid-level providers will provide decision support for mid-level providers in the current district healthcare system with specific protocols for target conditions. We will add the following elements: focus on mid-level, non-physician providers as the primary clinicians within the intervention; intensive Community Health Worker (CHW) outreach for detection, screening, follow-up of patients, and encouragement of patient self-care and behavior change; and focused effort on the seamless care coordination of patients across the tiers of the system. Through trainings of CHWs, much of patient self-management comes in the form of home visits that reinforce clinic and hospital counseling, including risk management and prevention. CHWs will be trained in the counseling of each target condition, with counseling largely occurring in the patients' homes, where much of the challenges of chronic disease management and behavior change lie.

Also known as: Task-Shifting, Healthcare Systems Strengthening
Health System Improvement

Clinical information systems. We are developing a system for tracking patients that integrates across each of the tiers using an electronic medical record. This is a key technology in supporting each of the above delivery system design elements.

Also known as: Electronic Medical Record
Health System Improvement

As a component of our comprehensive healthcare systems strengthening intervention, we are installing solar panels at community-level clinics to ensure continuous electrical supply for medical devices and technology.

Also known as: Solar Panel
Health System Improvement

As part of our healthcare systems strengthening intervention, we have established a performance-based financing agreement with the Government of Nepal that conditionally funds healthcare delivery based on population-level health outcomes and quality healthcare service delivery. In this arrangement, the Government serves as a regulator of healthcare delivery rather than a primary provider of healthcare services.

Health System Improvement

This is the current rural, district-level public sector healthcare infrastructure of rural Nepal that is not strengthened during the study.

Also known as: Control
Control

Eligibility Criteria

Age15 Years - 49 Years
Sexfemale
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Female
  • Reproductive age, 15-49 years
  • Resides within 14 village clusters that comprise experimental/control arms

You may not qualify if:

  • n/a

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Bayalpata Hospital

Sanfebagar, Achham, Nepal

RECRUITING

Charikot Primary Health Center

Bhimeshwor, Dolakha, Nepal

RECRUITING

Related Links

MeSH Terms

Conditions

Infant DeathMaternal Death

Interventions

Chronic Care ModelElectronic Health Records

Condition Hierarchy (Ancestors)

DeathPathologic ProcessesPathological Conditions, Signs and SymptomsParental Death

Intervention Hierarchy (Ancestors)

Delivery of Health Care, IntegratedDelivery of Health CarePatient Care ManagementHealth Services AdministrationMedical Records Systems, ComputerizedMedical RecordsRecordsData CollectionEpidemiologic MethodsInvestigative TechniquesOrganization and AdministrationHealth Care Evaluation MechanismsQuality of Health CareHealth Care Quality, Access, and EvaluationPublic HealthEnvironment and Public Health

Study Officials

  • David Citrin, PhD, MPH

    Possible

    STUDY DIRECTOR
  • Biraj Karmacharya, MBBS, MSc

    University of Washington

    STUDY CHAIR

Central Study Contacts

Duncan Maru, MD, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 8, 2013

First Posted

January 6, 2015

Study Start

November 1, 2014

Primary Completion

October 1, 2019

Study Completion

October 1, 2019

Last Updated

December 6, 2017

Record last verified: 2017-12

Locations