Postoperative Pain Relief After Cesarean Section: Is There a Role for the Quadratus Lumborum Block?

NCT02328378 | Completed

• 1 other identifier: Ch27021403
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The Quadratus Lumborum block (QLB) was first described by Blanco in 2007. The main advantage of QLB compared to the Transversus Abdominis Plane block (TAP) is the extension of local anesthetic agent beyond the TAP plane to the thoracic paravertebral space. The wider spread of the local anesthetic agents produces extensive analgesia and prolonged action of the injected local anesthetic solution. Previous studies showed that TAP block may not be effective in improving postoperative analgesia in patients who had cesarean section under spinal anaesthesia. The aim of this randomised controlled, double blinded study is to examine the effect of QLB on the postoperative pain management in patients who had cesarean section under spinal anesthesia.

Conditions

Postoperative Pain

Outcome Measures

Primary Outcomes (1)

• Total morphine used in the first 48 hours after surgery

  Total cumulative morphine dose in mg used in the first 48 hours after surgery

  48 hours

Secondary Outcomes (3)

• Nausea or vomiting

  48 hours

• Sedation score in the first 48 hours

  48 hours

• Severity of postoperative pain via visual analogue pain scale

  48 hours

Study Arms (2)

Quadratus Lumborum block group (QL)

ACTIVE COMPARATOR

patients will receive a bilateral Quadratus Lumborum block using Bupivicaine 0.125%

Procedure: Quadratus Lumborum block

Control Group

PLACEBO COMPARATOR

patients will receive a bilateral placebo block

Procedure: Quadratus Lumborum block

Interventions

Quadratus Lumborum block PROCEDURE

Patients will receive a bilateral Quadratus Lumborum block using 0.125% Bupivacaine in a dose of 0.2ml/kg body weight, after the end of surgery.

Control Group; Quadratus Lumborum block group (QL)

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Elective caesarean sections
• ASA 1 to 3
• Written informed consent.

You may not qualify if:

• Patient refusal
• Local infection at the site of injection
• Allergy to study medications
• Sepsis
• Anatomic abnormalities
• Systemic anticoagulation or coagulopathy
• Inability to comprehend or participate in pain scoring system
• Inability to use intravenous patient controlled analgesia

Sponsors & Collaborators

• Dr. Tarek Ansari: lead

Study Sites (1)

Corniche Hospital

Abu Dhabi, 3788, United Arab Emirates

Location

Related Publications (1)

• Blanco R, Ansari T, Girgis E. Quadratus lumborum block for postoperative pain after caesarean section: A randomised controlled trial. Eur J Anaesthesiol. 2015 Nov;32(11):812-8. doi: 10.1097/EJA.0000000000000299.

  PMID: 26225500 DERIVED

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Rafa Blanco, FRCA

  Corniche Hospital

  PRINCIPAL INVESTIGATOR

• Tarek Ansari, FFARCSI

  Corniche Hospital

  PRINCIPAL INVESTIGATOR

• Emad Girgis, MD

  Corniche Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Consultant Anesthetist

Study Record Dates

• First Submitted: December 25, 2014
• First Posted: December 31, 2014
• Study Start: September 1, 2014
• Primary Completion: March 1, 2015
• Study Completion: March 1, 2015
• Last Updated: May 24, 2016

Record last verified: 2016-05

Locations

AE (1)