NCT02327767

Brief Summary

The goal of this project is to test a device (Zondervan et al, 2013) that can provide active assistance for arm training for people in Vietnam with severe to moderate stroke, but that is also simple and does not rely on powered actuators. The hypothesis is that individuals with a severe chronic stroke, who exercise with a mechanically passive rehabilitation device, will have improved arm movement ability without experiencing an increase in arm pain.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jan 2015

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 24, 2014

Completed
6 days until next milestone

First Posted

Study publicly available on registry

December 30, 2014

Completed
2 days until next milestone

Study Start

First participant enrolled

January 1, 2015

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2015

Completed
Last Updated

January 5, 2015

Status Verified

January 1, 2015

Enrollment Period

2 months

First QC Date

December 24, 2014

Last Update Submit

January 2, 2015

Conditions

Keywords

Active AssistanceResonanceStrokeArm Rehabilitation

Outcome Measures

Primary Outcomes (1)

  • Upper Extremity-Fugl Meyer Assessment (UE-FMA)

    The UE-FMA will assess sensorimotor performance of the volunteer's arm and takes 30-minutes to complete. This includes assessing reflex activity, volitional movement within synergy, volitional movement mixing synergies, volitional movement out of synergy, wrist movement, hand movement, coordination, sensation and proprioception (Fugl-Meyer, 1975). A score of \< 35/66 indicated moderate to severe impairments, which will be used as a baseline measure.

    up to 6 weeks

Secondary Outcomes (2)

  • Stroke Impact Scale

    Baseline, 3 weeks, 6 weeks

  • Wong Baker Faces Pain Rating Scale

    Baseline, 3 weeks, 6 weeks

Study Arms (2)

Resonating Arm Exerciser

EXPERIMENTAL

The treatment group will participate in supervised Resonating Arm Exerciser (RAE) group sessions of 45 minutes, three times a week, for a total of eight sessions for three consecutive weeks. During each treatment session, the affected upper extremity will be used to push on the lever of the RAE in the sagittal plane. Upon pushing and pulling on the lever, the wheelchair moves a total of 20 cm from a neutral position, which indicated a repetition counted by a programed iphone.

Device: Resonating Arm Exerciser

Physical Therapy

NO INTERVENTION

The control group will continue with existing physical therapy treatment of passive range of motion (PROM) and therapeutic exercise to their involved upper extremity by the physical therapist.

Interventions

Participants in the exercise group will exercise using the device for 8 exercise sessions for 45 minutes per session for 3 consecutive weeks.

Resonating Arm Exerciser

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years or older
  • diagnosis of stoke more than six months post injury
  • patient in Da Nang, Vietnam
  • \<35 out of 66 on the UE-FMA
  • ability to perform one complete repetition with the RAE
  • participants' willingness to refrain from additional rehabilitation for the upper extremities during the duration of the RAE portion of the study.

You may not qualify if:

  • \< 24 out of 30 on the Mini-Mental State Examination (MMSE) (Mitrushina, 1991)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

DaNang Orthopedic and Rehabilitation Hospital

Da Nang, Vietnam

Location

Related Publications (4)

  • Zondervan DK, Palafox L, Hernandez J, Reinkensmeyer DJ. The Resonating Arm Exerciser: design and pilot testing of a mechanically passive rehabilitation device that mimics robotic active assistance. J Neuroeng Rehabil. 2013 Apr 18;10:39. doi: 10.1186/1743-0003-10-39.

    PMID: 23597303BACKGROUND
  • Fugl-Meyer AR, Jaasko L, Leyman I, Olsson S, Steglind S. The post-stroke hemiplegic patient. 1. a method for evaluation of physical performance. Scand J Rehabil Med. 1975;7(1):13-31.

    PMID: 1135616BACKGROUND
  • Vellone E, Savini S, Fida R, Dickson VV, Melkus GD, Carod-Artal FJ, Rocco G, Alvaro R. Psychometric evaluation of the Stroke Impact Scale 3.0. J Cardiovasc Nurs. 2015 May-Jun;30(3):229-41. doi: 10.1097/JCN.0000000000000145.

    PMID: 24695074BACKGROUND
  • Mitrushina M, Satz P. Reliability and validity of the Mini-Mental State Exam in neurologically intact elderly. J Clin Psychol. 1991 Jul;47(4):537-43. doi: 10.1002/1097-4679(199107)47:43.0.co;2-9.

    PMID: 1939698BACKGROUND

Related Links

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Study Officials

  • Janna Beling, PhD, PT

    California State University, Northridge

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Janna Beling, PhD, PT

CONTACT

Perez Scott, MA

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

December 24, 2014

First Posted

December 30, 2014

Study Start

January 1, 2015

Primary Completion

March 1, 2015

Study Completion

March 1, 2015

Last Updated

January 5, 2015

Record last verified: 2015-01

Locations