Assessment of a Proposed Microbiological Alert and Its Impact on a Sepsis Campaign

NCT02325258 | Completed

• 1 other identifier: MICRO.HGUGM.2012-001
• Study Type: interventional
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the present study was to evaluate the ability of health-care professionals in addressing sepsis, and the impact of a telephone call upon receival of blood cultures in the clinical microbiology department, from a clinical microbiologist, in the early management of sepsis.

Conditions

Sepsis

Keywords

Sepsis diagnosis; Sepsis drug therapy; Sepsis outcome

Outcome Measures

Primary Outcomes (1)

• Sepsis recognition in patients who had blood cultures drawn

  Use of diagnostic resources and antimicrobial consumption

  72 h

Secondary Outcomes (1)

• Health care professionals who correctly identify a case of sepsis

  72 h

Study Arms (2)

Telephone call

EXPERIMENTAL

Telephone call to physicians in charge of patients who have just had blood cultures drawn. Diagnostic and therapeutic recommendations to physicians in charge.

Other: Telephone call

No telephone call

NO INTERVENTION

control arm: no intervention

Interventions

Telephone call OTHER

Aug-Dec 2012. Prospective study in patients who had blood cultures drawn and sent to the Microbiology Lab during the morning shift (9 am to 3 pm, Mon- Fri) to evaluate sepsis recognition. The investigators allocated 300 patients to 2 groups of 150 patients each, by opportunity sampling: patients whose clinical history number ended in odd numbers were assigned to group A (intervention) and those whose clinical history number ended in even numbers were assigned to group B (no intervention, control group). For patients in group A, the investigators attempted a telephone contact with the physician and/or nurse in charge and an interview, issuing recommendations regarding the convenience of further biochemical, microbiological or extra radiologic tests, and management and antimicrobial therapy.

Telephone call

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients who had blood cultures drawn and sent to the Microbiology Laboratory, during the morning shift (from 9 am to 3 pm, Monday to Friday)
• Patients \>/=18 years old

You may not qualify if:

• Patients \<18 years old
• Patients with a recent bacteremic episode with no subsequent negative blood cultures
• In-patients with blood cultures drawn to whom the telephone call had already been performed.

Sponsors & Collaborators

• Emilio Bouza: lead

Study Sites (1)

Servicio de Microbiologia y Enfermedades Infecciosas

Madrid, Madrid, 28007, Spain

Location

Related Publications (1)

• Bunsow E, Vecchio MG, Sanchez C, Munoz P, Burillo A, Bouza E. Improved Sepsis Alert With a Telephone Call From the Clinical Microbiology Laboratory: A Clinical Trial. Medicine (Baltimore). 2015 Sep;94(39):e1454. doi: 10.1097/MD.0000000000001454.

  PMID: 26426609 DERIVED

MeSH Terms

Conditions

Sepsis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Emilio Bouza Santiago, MD, PhD

  Servicio de Microbiología y Enfermedades Infecciosas

  PRINCIPAL INVESTIGATOR

• Eleonora Bunsow, MD, PhD

  Servicio de Microbiología y Enfermedades Infecciosas

  STUDY DIRECTOR

• Marcela González Del Vecchio, MD

  Servicio de Microbiología y Enfermedades Infecciosas

  STUDY CHAIR

• Carlos Sánchez, PharmD

  Servicio de Microbiología y Enfermedades Infecciosas

  STUDY CHAIR

• Patricia Muñoz García, MD, PhD

  Servicio de Microbiología y Enfermedades Infecciosas

  STUDY CHAIR

• Almudena Burillo, MD, PhD

  Servicio de Microbiología y Enfermedades Infecciosas

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Head of Department

Study Record Dates

• First Submitted: December 19, 2014
• First Posted: December 24, 2014
• Study Start: August 1, 2012
• Primary Completion: January 1, 2013
• Study Completion: January 1, 2013
• Last Updated: December 30, 2014

Record last verified: 2014-12

Locations

ES (1)