Herpes Simplex Reactivation in Adult Critical Care Patients
1 other identifier
observational
140
0 countries
N/A
Brief Summary
Welcome or not Herpes Simplex virus (HSV) is an ever present guest in the intensive care unit (ICU). Several studies have documented a high frequency of HSV reactivation in critically ill patients despite that clinical impact remains unknown.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jan 2015
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 19, 2014
CompletedFirst Posted
Study publicly available on registry
December 23, 2014
CompletedStudy Start
First participant enrolled
January 1, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2015
CompletedDecember 23, 2014
December 1, 2014
1 month
November 19, 2014
December 22, 2014
Conditions
Outcome Measures
Primary Outcomes (1)
Incidence of HSV reactivation
Participants will be followed for the duration of the hospital stay with sampling of blood or tracheal secretions every 4 days until end of the viral reactivation period
Approximately 16 days
Secondary Outcomes (3)
Duration of mechanical ventilation
Approximately 16 days
ICU length of stay
Approximately 16 days
30/90 day mortality
30/90 days
Interventions
No intervention will be performed
Eligibility Criteria
Adult critically ill patients
You may qualify if:
- Admission to ICU
- Expected length of stay (LOS) \>72 hours
- Informed consent by patient, relative or guardian
You may not qualify if:
- Ongoing antiviral treatment/prophylaxis
- Expected LOS \<72 hours
- Withdrawal of informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Biospecimen
blood tracheal secretions
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD
Study Record Dates
First Submitted
November 19, 2014
First Posted
December 23, 2014
Study Start
January 1, 2015
Primary Completion
February 1, 2015
Study Completion
August 1, 2015
Last Updated
December 23, 2014
Record last verified: 2014-12