Psychophysical Correlates of Pain Reduction by Topical Analgesic Compounds

NCT02322164 | Completed

• 2 other identifiers: 15004815-AT-0048
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Background: \- Researchers are studying a topical (skin) cream that reduces pain. This is called an analgesic cream. They want to try a new test to better measure how well it works. Heat will be applied to the participants arms and they will judge the intensity of the temperatures. Researchers will compare the pain reduction from this cream to other pain relief treatments. Objective: \- To better measure the effects of a pain-relieving (analgesic) cream. Eligibility: \- Healthy volunteers ages 18 50. Design:

• There will be 2 study sessions.
• Session 1 will be about 1.5 hours.
• Participants will be screened with physical exam and urine drug test. They will answer medical and psychological questions.
• Participants will have sensory testing.
• A moisturizer will be put on their arms. A heating device will be placed on their arms. It gives heat pulses of about 2 seconds each. Some are warm and some are very hot. Participants will say how strong each pulse is. They can move away if it gets painful.
• Then the pain-relieving cream will be put on one arm. The moisturizer will be put on the other. Participants will get more pulses and rate them. They will also get pairs of pulses and compare them.
• Some participants will return for session 2 for 1 hour. They will receive similar sensory testing as in session 1.

Conditions

Healthy Volunteers

Keywords

Skin; TEMPERATURE; Placebo

Outcome Measures

Primary Outcomes (1)

• Thermal sensory discrimination

  One time point

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• You may be eligible to participate in this research study if you are:
• Between 18 and 50 years old.
• Fluent in English.
• Able to understand the procedures described in this document and give your written consent.

You may not qualify if:

• You may not be eligible to participate in this research study if you:
• Cannot complete the required procedures and tests in the study
• Used recreational drugs within the past six months
• Are in the third trimester of pregnancy
• Have a major medical condition or major medical history event that could affect touch and pain
• Have a medical condition that might affect touch and pain (e.g. Raynaud s Disease, peripheral neuropathy, or circulatory disorder)
• Have chronic pain or a history or chronic pain
• Have allergies to topical treatments
• Have a dermatological condition such as scars or burns, or have had a tattoo on your forearms within the previous four weeks that might influence touch or pain
• Had a recent or permanent injury of upper limbs or amputation or use a prosthetic limb
• Have participated in related NIH protocols (we will determine this)
• Used non-steroidal anti-inflammatory drugs (NSAIDS, e.g. aspirin, ibuprofen), acetaminophen, or sumatriptan within 3 days of testing (brand names include Advil, Tylenol, and Imitrex)
• Used narcotics (e.g. opioids, oxycodone) or pseudo narcotics (e.g. tramadol, tapentadol) within one week of testing (brand names include Percocet and Ultram)
• Use centrally acting medications like anticonvulsants (e.g. gabapentin, pregabalin), antidepressants (e.g. fluoxetine, duloxetine), antipsychotics (e.g. chlorpromazine, prochlorperazine), or anxiolytics (e.g. clonazepam, alprazolam) (Brand names include Neurontin, Lyrica, Prozac, Cymbalta, and Xanax)
• Use tobacco daily or used tobacco within 24 hours of testing

Sponsors & Collaborators

• National Center for Complementary and Integrative Health (NCCIH): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Study Officials

• Mary C Bushnell, Ph.D.

  National Center for Complementary and Integrative Health (NCCIH)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 19, 2014
• First Posted: December 23, 2014
• Study Start: December 19, 2014
• Primary Completion: September 21, 2017
• Study Completion: July 2, 2018
• Last Updated: July 5, 2018

Record last verified: 2018-07-02

Locations

US (1)