Exercise Post Bone Marrow Transplant

NCT02320942 | Unknown DMC

• 1 other identifier: H14-01679
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a preliminary study to assess whether it is possible to introduce an exercise program for BMT patients after discharge from hospital. The exercise program will include 3 endurance (stationary bike, walking) and 2 resistance (weights, stretch bands) training sessions/week, until 100 days after BMT. Our second plan is to test changes in QoL, aerobic fitness, muscle strength, total body fat and mineral composition, and blood immune markers with exercise in the 100 days after BMT. The investigators anticipate this study will improve the QoL, mobility, and strength of patients after BMT, therefore allowing a faster and healthier recovery.

Conditions

Leukemia

Keywords

Bone Marrow Transplantation; Exercise; Rehabilitation; Cancer

Outcome Measures

Primary Outcomes (1)

• Quality of Life

  European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30).

  Approximately 12-weeks

Secondary Outcomes (5)

• Baseline Demographics

  Baseline: pre-BMT visit.

• Aerobic Fitness

  Approximately 12-weeks

• Muscle Strength

  Approximately 12-weeks

• Body Composition

  Approximately 12-weeks

• Immune Function

  Approximately 12-weeks

Study Arms (1)

Exercise Intervention

EXPERIMENTAL

At discharge from the inpatient unit, participants will receive a practical introduction by an exercise specialist and enrolled in the 12-week exercise intervention

Other: Exercise Intervention

Interventions

Exercise Intervention OTHER

The semi-supervised intervention is a progressive program with a goal of three aerobic and two resistance exercise sessions per week. Aerobic exercise will consist of 20-40 minutes of bicycling using a stationary bike located on CP6 (supervised or un-supervised) or brisk walking at home. Resistance exercise will include exercise for the upper and lower extremities with stretch bands. Patients will complete at least one supervised aerobic and resistance session per week with the exercise trainer and complete a daily log of their exercise, including adherence, adverse events and symptoms.

Exercise Intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults ≥ 18 years of age
• Undergoing alloHSCT for any indication through the LBMT Program of BC at VGH
• Good comprehension of English (must be able to fill out questionnaires in English)

You may not qualify if:

• Contraindications to entrance into an exercise program (i.e., known cardiovascular disease, musculoskeletal issue or not cleared for exercise by the attending physician)
• Mobility impairment requiring use of mobility aids

Sponsors & Collaborators

• University of British Columbia: lead
• British Columbia Cancer Agency: collaborator

Study Sites (1)

Vancouver General Hospital - Krall Centre Centennial Pavilion 6

Vancouver, British Columbia, V5Z1M9, Canada

RECRUITING

MeSH Terms

Conditions

Leukemia; Motor Activity; Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Histologic Type; Hematologic Diseases; Hemic and Lymphatic Diseases; Behavior

Study Officials

• Raewyn Broady, MBChB

  British Columbia Cancer Agency

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Raewyn Broady

CONTACT

604-875-4952; RBroady@bccancer.bc.ca

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 16, 2014
• First Posted: December 19, 2014
• Study Start: October 1, 2014
• Primary Completion: December 1, 2015
• Study Completion: December 1, 2015
• Last Updated: August 26, 2015

Record last verified: 2015-08

Locations

CA (1)