Estudo Longitudinal de Saúde do Adulto (Brazilian Longitudinal Study of Adult Health )

NCT02320461 | Unknown

• 1 other identifier: 01.06.0010.00
• Study Type: observational
• Target: 15,105
• Locations: 0 countries
• Sites: N/A

Brief Summary

The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute with relevant information regarding the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes. The investigators enrolled 15,105 civil servants from predefined universities or research institutes. Baseline assessment (2008-2010) included detailed interviews and measurements to assess social and biological determinants of health, as well as various clinical and subclinical conditions related to diabetes, cardiovascular diseases and mental health. For the ascertainment of incident events, annual telephone surveillance is being conducted since 2009, and a second visit of interviews and exams is under way (2012-2014). Long-term biological sample storage is provided for sera, plasma, urine and DNA. Baseline data is available for analyses, and collaboration via specific research proposals directed to study investigators is welcome. This multicenter study is chaired by a steering committee, made up of the coordinators and vice-coordinators of each of the six centers. No individual center coordinates the study. The six institutions listed in the contact details all sponsor the study.

Conditions

Diabetes Mellitus; Cardiovascular Diseases

Keywords

diabetes mellitus; cardiovascular diseases; cohort studies; hypertension; obesity; smoking; social class

Outcome Measures

Primary Outcomes (2)

• Diabetes mellitus (Incident cases)

  Incident cases

  6 years

• Myocardial infarction (Incident cases)

  Incident cases

  6 years

Eligibility Criteria

• Age: 35 Years - 74 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

ELSA-Brasil is a cohort study of 15,105 civil servants. All active or retired employees of the six institutions (and, in a few instances, also of related educational or health institutions), of both sexes, and with ages between 35 and 74 years, were eligible for the study. The six institutions, located in three different Brazilian regions, are: the Federal Universities of Bahia, Espirito Santo, Minas Gerais and Rio Grande do Sul, the University of Sao Paulo and the Oswaldo Cruz Foundation.

You may qualify if:

• age 35-74 years,
• active or retired employees of the institutions involved or affiliated institutions.

You may not qualify if:

• current or recent (\<4 months prior to the first interview) pregnancy,
• intention to quit work at the institution in the near future,
• severe cognitive or communication impairment and,
• if retired, residence outside each center´s corresponding metropolitan area.

Sponsors & Collaborators

• Federal University of Rio Grande do Sul: lead

Related Publications (6)

• Aquino EM, Barreto SM, Bensenor IM, Carvalho MS, Chor D, Duncan BB, Lotufo PA, Mill JG, Molina Mdel C, Mota EL, Passos VM, Schmidt MI, Szklo M. Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): objectives and design. Am J Epidemiol. 2012 Feb 15;175(4):315-24. doi: 10.1093/aje/kwr294. Epub 2012 Jan 10.

  PMID: 22234482 BACKGROUND

• Schmidt MI, Duncan BB, Mill JG, Lotufo PA, Chor D, Barreto SM, Aquino EM, Passos VM, Matos SM, Molina Mdel C, Carvalho MS, Bensenor IM. Cohort Profile: Longitudinal Study of Adult Health (ELSA-Brasil). Int J Epidemiol. 2015 Feb;44(1):68-75. doi: 10.1093/ije/dyu027. Epub 2014 Feb 27.

  PMID: 24585730 BACKGROUND

• Birck MG, Almeida-Pititto B, Janovsky CCPS, Goulart AC, Santos IS, Teixeira PFDS, Sgarbi JA, Barreto SM, Duncan BB, Schmidt MI, Lotufo PA, Bensenor IM. Thyroid-Stimulating Hormone and Thyroid Hormones and Incidence of Diabetes: Prospective Results of the Brazilian Longitudinal Study of Adult Health (ELSA-BRASIL). Thyroid. 2022 Jun;32(6):694-704. doi: 10.1089/thy.2021.0533. Epub 2022 May 24.

  PMID: 35473396 DERIVED

• Riboldi BP, Luft VC, Bracco PA, de Oliveira Cardoso L, Molina MDC, Alvim S, Giatti L, Schmidt MI, Duncan BB. The inflammatory food index and its association with weight gain and incidence of diabetes: Longitudinal Study of Adult Health (ELSA-Brasil). Nutr Metab Cardiovasc Dis. 2022 Mar;32(3):675-683. doi: 10.1016/j.numecd.2021.12.022. Epub 2022 Jan 6.

  PMID: 35123853 DERIVED

• Drehmer M, Odegaard AO, Schmidt MI, Duncan BB, Cardoso LO, Matos SMA, Molina MDCB, Barreto SM, Pereira MA. Brazilian dietary patterns and the dietary approaches to stop hypertension (DASH) diet-relationship with metabolic syndrome and newly diagnosed diabetes in the ELSA-Brasil study. Diabetol Metab Syndr. 2017 Feb 13;9:13. doi: 10.1186/s13098-017-0211-7. eCollection 2017.

  PMID: 28228848 DERIVED

• Drehmer M, Pereira MA, Schmidt MI, Del Carmen B Molina M, Alvim S, Lotufo PA, Duncan BB. Associations of dairy intake with glycemia and insulinemia, independent of obesity, in Brazilian adults: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Am J Clin Nutr. 2015 Apr;101(4):775-82. doi: 10.3945/ajcn.114.102152. Epub 2015 Jan 21.

  PMID: 25833975 DERIVED

Related Links

• Public website of the study

Biospecimen

Retention: SAMPLES WITH DNA

Frozen serum and urine samples

MeSH Terms

Conditions

Diabetes Mellitus; Cardiovascular Diseases; Hypertension; Obesity; Smoking

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Vascular Diseases; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Study Officials

• Estela M Aquino, MD

  Federal University of Bahia

  PRINCIPAL INVESTIGATOR

• José G Mill, MD

  Federal University of Espirito Santo

  PRINCIPAL INVESTIGATOR

• Sandhi M Barreto, MD

  Universidade Federal da Minas Gerais

  PRINCIPAL INVESTIGATOR

• Rosane H Griep, DSc

  Fundação Oswaldo Cruz

  PRINCIPAL INVESTIGATOR

• Paulo A Lotufo, MD

  University of Sao Paulo

  PRINCIPAL INVESTIGATOR

• Maria I Schmidt, MD

  Federal University of Rio Grande do Sul

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: December 16, 2014
• First Posted: December 19, 2014
• Study Start: August 1, 2008
• Primary Completion: December 1, 2020
• Study Completion: December 1, 2020
• Last Updated: December 19, 2014

Record last verified: 2014-12