Epidemiologic Features of Kawasaki Disease in Shanghai From 2008 Through 2012

NCT02317913 | Completed DMC

• 1 other identifier: kd2008-2012
• Study Type: observational
• Target: 2,402
• Locations: 1 country
• Sites: 1

Brief Summary

To investigate the epidemiological pictures of Kawasaki disease (KD) in Shanghai from 2008 through 2012, and illustrate the risk factors of coronary arterial lesions .

Conditions

Kawasaki Disease

Keywords

Kawasaki disease; Epidemiology; Incidence; Coronary arterial lesions; Shanghai

Outcome Measures

Primary Outcomes (1)

• incidence of coronary artery lesions(CAL)

  according to the result of the echocardiography performed in the acute phase ,early and late recovery of Kawasaki disease

  5 years

Eligibility Criteria

• Age: 1 Day - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

All patients with KD diagnosed during January 2008 through December 2012 in Shanghai

You may qualify if:

• The 5th revised edition of diagnostic criteria for KD, issued by the Japan Kawasaki Disease Research Committee at the 7th International Kawasaki Disease Symposium in 2002, was adopted. Cases were included in the study if the patients had at least five of the following six clinical manifestations or at least four signs together with coronary abnormalities documented by echocardiography or coronary angiography:
• fever persisting 5 days or longer (inclusive of those cases in whom the fever has subsided before the 5th day in response to therapy)
• bilateral conjunctival congestion
• changes of lips and oral cavity, such as reddening of lips, strawberry tongue, diffuse congestion of oral and pharyngeal mucosa
• polymorphous exanthema
• changes of peripheral extremities, such as reddening of palms and soles, indurative edema at initial stage, or membranous desquamation from fingertips at convalescent stage
• acute nonpurulent cervical lymphadenopathy. In addition, the cases of incomplete KD, diagnosed with referring to the guidelines for incomplete KD made by American Academy of Pediatrics (AAP) and American Heart Association (AHA) in 2004, were also included in this investigation

You may not qualify if:

• The cases were not in accordance with the recruited criteria

Sponsors & Collaborators

• Children's Hospital of Fudan University: lead
• Shanghai Children's Medical Center: collaborator
• Xinhua Hospital, Shanghai Jiao Tong University School of Medicine: collaborator
• Ruijin Hospital: collaborator
• Shanghai 6th People's Hospital: collaborator
• Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine: collaborator
• Changhai Hospital: collaborator
• Shanghai Tongji Hospital, Tongji University School of Medicine: collaborator

Study Sites (1)

Children Hospital of Fudan University

Shanghai, Shanghai Municipality, 201102, China

Location

Related Publications (1)

• Chen JJ, Ma XJ, Liu F, Yan WL, Huang MR, Huang M, Huang GY; Shanghai Kawasaki Disease Research Group. Epidemiologic Features of Kawasaki Disease in Shanghai From 2008 Through 2012. Pediatr Infect Dis J. 2016 Jan;35(1):7-12. doi: 10.1097/INF.0000000000000914.

  PMID: 26372452 DERIVED

MeSH Terms

Conditions

Mucocutaneous Lymph Node Syndrome

Condition Hierarchy (Ancestors)

Vasculitis; Vascular Diseases; Cardiovascular Diseases; Lymphatic Diseases; Hemic and Lymphatic Diseases; Skin Diseases, Vascular; Skin Diseases; Skin and Connective Tissue Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor,President

Study Record Dates

• First Submitted: December 8, 2014
• First Posted: December 17, 2014
• Study Start: April 1, 2013
• Primary Completion: November 1, 2015
• Study Completion: January 1, 2016
• Last Updated: March 10, 2016

Record last verified: 2015-03

Locations

CN (1)