Protein Nutrition for Muscle Hypertrophy in Older Adults
Efficacy of Isolated Whey and Micellar Whey Protein (+/- Citrulline) to Stimulate Protein Synthesis in 'Healthy' and 'Anabolically Resistant' Elderly Muscle
1 other identifier
interventional
30
0 countries
N/A
Brief Summary
The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Sep 2012
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2013
CompletedFirst Submitted
Initial submission to the registry
November 12, 2014
CompletedFirst Posted
Study publicly available on registry
December 11, 2014
CompletedDecember 18, 2014
November 1, 2014
1.2 years
November 12, 2014
December 17, 2014
Conditions
Outcome Measures
Primary Outcomes (1)
Change in myofibrillar fractional synthetic rate (FSR)
one day and 2 weeks
Secondary Outcomes (2)
change in non-myofibrillar fractional synthetic rate (FSR)
baseline and one day of feeding
Capillary dilatation and blood flow
2 weeks
Study Arms (3)
20g isolated whey protein + 30g carb, 8,5g fat, 15g glycine
EXPERIMENTAL20g isolated whey protein + 30g carb, 8,5g fat, 15g glycine
20g micellar whey protein + 30g carb, 8.5g fat, 15g glycine
EXPERIMENTAL20g micellar whey protein + 30g carb, 8.5g fat, 15g glycine
20g micellar whey protein + 30g carb, 8.5g fat, 5g citrulline
EXPERIMENTAL20g micellar whey protein + 30g carb, 8.5g fat, 5g citrulline
Interventions
isolated whey protein
micellar whey protein
glycine
Eligibility Criteria
You may qualify if:
- Must habitually complete a minimum of 5000 steps per day
- Having obtained informed consent
- Non-obese
- Non-smoker
You may not qualify if:
- Aged \>80 years
- Inability to comply with study procedures
- Currently participating or having participated in another infusion trial during last 12 months
- Any acute or chronic llness
- History of neuromuscular problems
- Medications known to affect protein metabolism
- Individuals who complete fewer than 5000 steps per day
- Individuals who have metal implants
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Stuart Philips, PhD
McMaster University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 12, 2014
First Posted
December 11, 2014
Study Start
September 1, 2012
Primary Completion
December 1, 2013
Study Completion
December 1, 2013
Last Updated
December 18, 2014
Record last verified: 2014-11