International Registry on the Use of the CytoSorb Adsorber
CytoSorb
1 other identifier
observational
1,434
3 countries
19
Brief Summary
Registry on the use of the CytoSorb® adsorber in ICU patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2015
Longer than P75 for all trials
19 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 4, 2014
CompletedFirst Posted
Study publicly available on registry
December 9, 2014
CompletedStudy Start
First participant enrolled
January 1, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 4, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
February 4, 2021
CompletedOctober 23, 2024
December 1, 2019
6.1 years
December 4, 2014
October 21, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Difference between mortality predicted by scoring systems (APACHE II/SAPS II, EuroSCORE II) and actual mortality within 30 days after intervention
days
Secondary Outcomes (6)
- Organ function (SOFA - score-difference)
days
- Concentration of biomarkers IL-6, CRP, PCT, myoglobin, free hemoglobin
days
- Length of hospital and ICU stay (days)
days
- Duration of mechanical ventilation (days)
days
- Duration of renal replacement therapy (days)
days
- +1 more secondary outcomes
Study Arms (4)
Patients with severe sepsis/septic shock
Use of CytoSorb adsorber in patients with severe sepsis/septic shock
Cardiac surgery with CPB: preemptive use
Use of CytoSorb adsorber in patients with cardiac surgery with CPB: preemptive use
Cardiac surgery with CPB: postop. use
Use of CytoSorb adsorber in patients with cardiac surgery with CPB: postoperative use
Patients with other indications
Use of CytoSorb adsorber in patients with other indications
Interventions
Use of CytoSorb adsorber either in patients with severe sepsis/septic shock or with cardiac surgery with CPB or in other patients.
Eligibility Criteria
Patients undergoing treatment with the CytoSorb® adsorber
You may qualify if:
- Use of the CytoSorb® adsorber
- Age ≥ 18 years
- Signed informed consent
You may not qualify if:
- \- none
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Jena University Hospitallead
- University Hospital Goettingencollaborator
Study Sites (19)
Krankenhaus Hietzing
Vienna, Austria
Vivantes Klinikum Neukölln
Berlin, Germany
Evangelisches Krankenhaus
Bielefeld, Germany
Carl-Thiem-Klinikum
Cottbus, Germany
Universitätsklinikum Düsseldorf
Düsseldorf, Germany
Klinikum Emden
Emden, Germany
Kliniken Erlabrunn gGmbH
Erlabrunn, Germany
Universitätsklinikum Freiburg
Freiburg im Breisgau, Germany
Universitätsmedizin Göttingen
Göttingen, Germany
Greifswald University Hospital
Greifswald, Germany
Krankenhaus St. Elisabeth & St. Barbara
Halle, Germany
Universitätsklinikum Hamburg-Eppendorf
Hamburg, Germany
Krankenhaus Herzberg, Elbe-Elster-Klinikum GmbH
Herzberg, Germany
Kliniken Maria Hilf GmbH Mönchengladbach
Mönchengladbach, Germany
Klinikum rechts der Isar der TU München
München, Germany
Klinikum Oldenburg
Oldenburg, Germany
University Hospital Ulm
Ulm, Germany
Kliniken Nordoberpfalz AG, Klinikum Weiden
Weiden, Germany
University of Szeged
Szeged, Hungary
Related Publications (3)
Hawchar F, Tomescu D, Trager K, Joskowiak D, Kogelmann K, Soukup J, Friesecke S, Jacob D, Gummert J, Faltlhauser A, Aucella F, van Tellingen M, Malbrain MLNG, Bogdanski R, Weiss G, Herbrich A, Utzolino S, Nierhaus A, Baumann A, Hartjes A, Henzler D, Grigoryev E, Fritz H, Bach F, Schroder S, Weyland A, Gottschaldt U, Menzel M, Zachariae O, Novak R, Berden J, Haake H, Quintel M, Kloesel S, Kortgen A, Stecher S, Torti P, Nestler F, Nitsch M, Olboeter D, Muck P, Findeisen M, Bitzinger D, Krassler J, Benad M, Schott M, Schumacher U, Molnar Z, Brunkhorst FM. Hemoadsorption in the critically ill-Final results of the International CytoSorb Registry. PLoS One. 2022 Oct 25;17(10):e0274315. doi: 10.1371/journal.pone.0274315. eCollection 2022.
PMID: 36282800BACKGROUNDSchittek GA, Zoidl P, Eichinger M, Orlob S, Simonis H, Rief M, Metnitz P, Fellinger T, Soukup J. Adsorption therapy in critically ill with septic shock and acute kidney injury: a retrospective and prospective cohort study. Ann Intensive Care. 2020 Nov 18;10(1):154. doi: 10.1186/s13613-020-00772-7.
PMID: 33206229DERIVEDFriesecke S, Trager K, Schittek GA, Molnar Z, Bach F, Kogelmann K, Bogdanski R, Weyland A, Nierhaus A, Nestler F, Olboeter D, Tomescu D, Jacob D, Haake H, Grigoryev E, Nitsch M, Baumann A, Quintel M, Schott M, Kielstein JT, Meier-Hellmann A, Born F, Schumacher U, Singer M, Kellum J, Brunkhorst FM. International registry on the use of the CytoSorb(R) adsorber in ICU patients : Study protocol and preliminary results. Med Klin Intensivmed Notfmed. 2019 Nov;114(8):699-707. doi: 10.1007/s00063-017-0342-5. Epub 2017 Sep 4.
PMID: 28871441DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Frank M. Brunkhorst, Prof.
Center for Clinical Studies at Jena University Hospital
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Target Duration
- 30 Days
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 4, 2014
First Posted
December 9, 2014
Study Start
January 1, 2015
Primary Completion
February 4, 2021
Study Completion
February 4, 2021
Last Updated
October 23, 2024
Record last verified: 2019-12