The NOR-COR Study for Coronary Prevention

NCT02309255 | Completed

• 1 other identifier: NOR-COR REK ID 2013/1885
• Study Type: observational
• Target: 975
• Locations: 1 country
• Sites: 1

Brief Summary

The NOR-COR study is a cross-sectional, observational study designed to explore a large number of cardiovascular, inflammatory, genetic, behavioral, and psychosocial factors (including anxiety, depression, quality of life) in 1369 patients with established coronary heart disease (CHD) hospitalized in the Sections for Cardiology at the hospitals in Drammen (n=722) and Vestfold (n=647). Study data from an extensive questionnaire, clinical and laboratory data, and sputum/saliva for genetic analyses will be collected. The main overall aim of the NOR-COR study is to develop new strategies to improve secondary prevention for underserved high risk patient-groups with CHD. The first study phase aims to collect information necessary to develop empirically based future secondary coronary prevention interventions. In a genetic sub-project markers associated with CHD and personality type will be explored. The study will evaluate current secondary preventive programs and explore the mechanisms that link behavioral, psychosocial, inflammatory, and genetic factors to poor prognosis. The study will in short term provide new knowledge potentially useful for increasing participation in current cardiac rehabilitation/secondary preventive programs. For a longer perspective these associations may be useful for design of new intervention programs to selected high risk patient groups whom may be in need of programs with different content and/or of longer duration than those currently being applied.

Conditions

Secondary Coronary Prevention

Keywords

Secondary coronary prevention; Psychosocial factors; Cardiac rehabilitation

Outcome Measures

Primary Outcomes (1)

• Cardiovascular risk factors, lifestyle, and drug adherence

  Within 2 years after study inclusion

Secondary Outcomes (1)

• Readmission with a coronary event, acute myocardial infarctrion and cardiovascular mortality

  Within 5 years after study inclusion

Other Outcomes (1)

• The hospital anxiety and depression scale (HADS)

  Within 2 years after study inclusion

Study Arms (1)

coronary heart disease patients

Other: no intervention

Interventions

no intervention OTHER

coronary heart disease patients

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

1365 CHD patients

You may qualify if:

• All patients aged 18-80 years with first or recurrent diagnosis or treatments for CHD: a) acute myocardial infarction \[ICD-10; I21\], b) coronary artery by-pass graft operation (CABG), or c) elective or emergency PCI \[ICD-10; I25\]) have been identified from hospital patient discharge lists (diagnostic lists) by searching chronologically after last admission the past three years. In patients with recurrent diagnosis the last event will define the event.

You may not qualify if:

• Cognitive impairment that would invalidate assessment including all patients living at nursing home and psychosis.
• Short life expectancy (i.e. \<1 year) due to terminal heart (NYHA class 4), lung (chronic obstructive pulmonary disease GOLD 4)-, liver- or kidney disease (chronic kidney disease stage 5), malignant disease, or other reason.
• Not able to understand and write the Norwegian language or refuse to give written informed consent to study participation.

Sponsors & Collaborators

• Vestre Viken Hospital Trust: lead
• The Hospital of Vestfold: collaborator
• Oslo University Hospital: collaborator
• Kalmar County Hospital: collaborator

Study Sites (1)

Vestre Viken HF, Drammen Hospital and The Hospital of Vestfold

Drammen and Tønsberg, Buskerud and Vestfold, N-3004, Norway

Location

Related Publications (5)

• Sverre E, Peersen K, Perk J, Husebye E, Gullestad L, Dammen T, Otterstad JE, Munkhaugen J. Challenges in coronary heart disease prevention - experiences from a long-term follow-up study in Norway. Scand Cardiovasc J. 2021 Apr;55(2):73-81. doi: 10.1080/14017431.2020.1852308. Epub 2020 Dec 4.

  PMID: 33274648 DERIVED

• Sverre E, Peersen K, Weedon-Fekjaer H, Perk J, Gjertsen E, Husebye E, Gullestad L, Dammen T, Otterstad JE, Munkhaugen J. Preventable clinical and psychosocial factors predicted two out of three recurrent cardiovascular events in a coronary population. BMC Cardiovasc Disord. 2020 Feb 5;20(1):61. doi: 10.1186/s12872-020-01368-6.

  PMID: 32024471 DERIVED

• Munkhaugen J, Hjelmesaeth J, Otterstad JE, Helseth R, Sollid ST, Gjertsen E, Gullestad L, Perk J, Moum T, Husebye E, Dammen T. Managing patients with prediabetes and type 2 diabetes after coronary events: individual tailoring needed - a cross-sectional study. BMC Cardiovasc Disord. 2018 Aug 3;18(1):160. doi: 10.1186/s12872-018-0896-z.

  PMID: 30075751 DERIVED

• Sverre E, Otterstad JE, Gjertsen E, Gullestad L, Husebye E, Dammen T, Moum T, Munkhaugen J. Medical and sociodemographic factors predict persistent smoking after coronary events. BMC Cardiovasc Disord. 2017 Sep 6;17(1):241. doi: 10.1186/s12872-017-0676-1.

  PMID: 28877684 DERIVED

• Sverre E, Peersen K, Husebye E, Gjertsen E, Gullestad L, Moum T, Otterstad JE, Dammen T, Munkhaugen J. Unfavourable risk factor control after coronary events in routine clinical practice. BMC Cardiovasc Disord. 2017 Jan 21;17(1):40. doi: 10.1186/s12872-016-0387-z.

  PMID: 28109259 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Salvia for genetic analyses

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 24, 2014
• First Posted: December 5, 2014
• Study Start: February 1, 2014
• Primary Completion: April 1, 2015
• Study Completion: April 1, 2015
• Last Updated: June 15, 2015

Record last verified: 2015-06

Locations

NO (1)