NCT02305771

Brief Summary

The aim of the study is to demonstrate that our semantic knowledge (elements of our long-term memory and the process we use them) respond to a graphic organisation and gather together following accurate patterns called cliques (neural networks).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
21

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Feb 2015

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 28, 2014

Completed
5 days until next milestone

First Posted

Study publicly available on registry

December 3, 2014

Completed
3 months until next milestone

Study Start

First participant enrolled

February 27, 2015

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 20, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 20, 2015

Completed
Last Updated

May 24, 2023

Status Verified

May 1, 2023

Enrollment Period

9 months

First QC Date

November 28, 2014

Last Update Submit

May 22, 2023

Conditions

Epilepsy

Outcome Measures

Primary Outcomes (2)

  • Three main criteria are to be considered to validate the tool for measuring the similarity between the graphs obtained

    Despite the intra-individual variability, the same object or the same sound repeated several times should generate the most similar connectivity graphs Despite the inter-individual variability, analysis of connectivity graphs must also report high similarity indices between individuals on the same stimuli or stimuli sharing the same semantic properties even if subjects are different. At the stage of conceptual analysis of stimuli, or from 175 ms after the presentation of the image or sound, the analysis of connectivity graphs should reveal strong similarity indices for several different images of the same object (independence to the visual representation); for picture and sound representing the same object (independence to the sensory modality) or two objects belonging to the same semantic category (conceptual similarity, eg: orange, lemon). Indeed, these objects share common characteristics / semantic dimensions (eg mobile vs. stationary or living vs. non-living etc.).

    2 years

  • Estimate the plausibility of the results obtained with our method directly from the graphs

    The density (ie: the ratio between the number of links in a given graph on the total possible number of links), the diameter (ie: the longest path in a graph), the average degree (ie: the average number of links connected to each node), the clustering (ie: the density of connections to a group of nodes with the rest of the network) and other parameters will be compared in terms of standard values available in the literature but also with tools that help to calculate the semantic distance between words such as WordNet and many others.

    2 years

Secondary Outcomes (1)

  • Judgement of the quality of the measurement on simulated data in the laboratory test our method for measuring the similarity between the graphs

    2 years

Study Arms (1)

Healthy volunteers

OTHER

20 healthy volunteers will undergo an inclusion visit in order to check inclusion and non inclusion criteria. Then will be performed: * Electroencephalography * MRI

Device: ElectroencephalographyDevice: MRI

Interventions

ElectroencephalographyDEVICE
Healthy volunteers
MRIDEVICE
Healthy volunteers

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years and older
  • Right-handed ;
  • French native speaker
  • Having given written informed consent

You may not qualify if:

  • Presence of any psychiatric, neuropsychological and developmental disorder
  • Any uncorrected visual impairment
  • Any trouble or delay in learning to read / speak french
  • Fully bilingual or multilingual
  • Medication, treatment and / or substances that may alter or modify brain functions
  • Pregnancy, breast feeding
  • Persons under major legal protection and/or deprived of liberty
  • MRI-related criterions
  • Cardiac pacemaker or implanted defibrillator
  • Iron-magnetic surgical clips
  • Cochlear implant
  • Intra-ocular or brain foreign bodies
  • Less than 4 weeks-old stents, less than 6 weeks-old osteosynthesis materials
  • Claustrophobia

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Rennes University Hospital

Rennes, 35033, France

Location

Related Publications (1)

  • Mheich A, Dufor O, Yassine S, Kabbara A, Biraben A, Wendling F, Hassan M. HD-EEG for tracking sub-second brain dynamics during cognitive tasks. Sci Data. 2021 Jan 27;8(1):32. doi: 10.1038/s41597-021-00821-1.

    PMID: 33504796RESULT

MeSH Terms

Conditions

Epilepsy

Interventions

Electroencephalography

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, NeurologicalDiagnostic Techniques and ProceduresDiagnosisElectrodiagnosis

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
OTHER
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 28, 2014

First Posted

December 3, 2014

Study Start

February 27, 2015

Primary Completion

November 20, 2015

Study Completion

November 20, 2015

Last Updated

May 24, 2023

Record last verified: 2023-05

Locations

FR(1)