Physical Activity in Relation to Surgical Procedures

NCT02299596 | Completed

• 1 other identifier: Physsurg C - the RCT
• Study Type: interventional
• Target: 761
• Locations: 1 country
• Sites: 2

Brief Summary

This study will compare the outcome after surgery between a group of patients that receives instructions for prehabilitation training and one group that received standard treatment.

Conditions

Colorectal Cancer; Surgery

Keywords

Colorectal neoplasm; Physical activity

Outcome Measures

Primary Outcomes (1)

• Recovery measured as physical recovery measured in questionnaire

  4-6 weeks

Secondary Outcomes (15)

• Psychological recovery measured in a questionnaire, patient reported

  4-6 weeks and 1 year post-operatively

• Recovery measured as time back to work

  1 year

• Complications according to Clavien-Dindo

  within 90 days

• QoL measured using SF-36

  4-6 weeks and 1 year

• QoL measured using EQ-5D

  4-6 weeks and 1 year

Study Arms (2)

Pre and postoperative exercise

EXPERIMENTAL

The intervention is prehabilitation preoperatively and physical training postoperatively. During the hospital stay both groups will be treated in the same manner. Preoperative intervention: One half hour of exercise daily added to the existing daily exercise routine. The level of exercise should produce shortness of breath but the patient should be able to talk without much effort. Inspiratory muscle training. Thirty breaths x two twice daily. Postoperative intervention is mainly the same as preoperatively.

Other: Physical activity

Control

NO INTERVENTION

Standard treatment with one exception, patients will fill in a physical activity diary

Interventions

Physical activity OTHER

The intervention will take place both pre- and postoperatively. During the hospital stay both groups will be treated in the same manner.

Pre and postoperative exercise

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosed colorectal cancer and a planned surgical procedure

You may not qualify if:

• HIPEC surgery, not able to give informed consent or understand the intervention

Sponsors & Collaborators

• Sahlgrenska University Hospital: lead

Study Sites (2)

Sahlgrenska University Hospital/Östra

Gothenburg, 416 85, Sweden

Location

Dept. of Surgery, Skaraborgs Sjukhus

Skövde, Sweden

Location

Related Publications (5)

• Onerup A, Li Y, Afshari K, Angenete E, de la Croix H, Ehrencrona C, Wedin A, Haglind E. Long-term results of a short-term home-based pre- and postoperative exercise intervention on physical recovery after colorectal cancer surgery (PHYSSURG-C): a randomized clinical trial. Colorectal Dis. 2024 Mar;26(3):545-553. doi: 10.1111/codi.16860. Epub 2024 Jan 15.

  PMID: 38225857 DERIVED

• Molenaar CJ, van Rooijen SJ, Fokkenrood HJ, Roumen RM, Janssen L, Slooter GD. Prehabilitation versus no prehabilitation to improve functional capacity, reduce postoperative complications and improve quality of life in colorectal cancer surgery. Cochrane Database Syst Rev. 2023 May 10;5(5):CD013259. doi: 10.1002/14651858.CD013259.pub3.

  PMID: 37162250 DERIVED

• Molenaar CJ, van Rooijen SJ, Fokkenrood HJ, Roumen RM, Janssen L, Slooter GD. Prehabilitation versus no prehabilitation to improve functional capacity, reduce postoperative complications and improve quality of life in colorectal cancer surgery. Cochrane Database Syst Rev. 2022 May 19;5(5):CD013259. doi: 10.1002/14651858.CD013259.pub2.

  PMID: 35588252 DERIVED

• Onerup A, Thorn SE, Angenete E, Bock D, Gryback Gillheimer E, Haglind E, Nilsson H. Effects of a home-based exercise program on the insulin-like growth factor axis in patients operated for colorectal cancer in Sweden: Results from the randomised controlled trial PHYSSURG-C. Growth Horm IGF Res. 2020 Apr;51:27-33. doi: 10.1016/j.ghir.2020.01.005. Epub 2020 Jan 28.

  PMID: 32007834 DERIVED

• Onerup A, Angenete E, Bock D, Borjesson M, Fagevik Olsen M, Gryback Gillheimer E, Skullman S, Thorn SE, Haglind E, Nilsson H. The effect of pre- and post-operative physical activity on recovery after colorectal cancer surgery (PHYSSURG-C): study protocol for a randomised controlled trial. Trials. 2017 May 8;18(1):212. doi: 10.1186/s13063-017-1949-9.

  PMID: 28482864 DERIVED

MeSH Terms

Conditions

Colorectal Neoplasms; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Eva Haglind, M.D., Ph.D.

  SSORG

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant Surgeon, Professor

Study Record Dates

• First Submitted: November 17, 2014
• First Posted: November 24, 2014
• Study Start: January 1, 2015
• Primary Completion: May 31, 2020
• Study Completion: December 31, 2025
• Last Updated: April 27, 2026

Record last verified: 2026-04

Locations

SE (2)