Effect of Vit D on New-onset AF in Hypertension
Relation of Low Vitamin D Levels and New-onset AF Among Hypertensive Patients
1 other identifier
observational
227
0 countries
N/A
Brief Summary
Atrial fibrillation (AF), an important cause of cardiac mortality and morbidity is the most common type of cardiac arrhythmia in clinical practice. Hypertensive individuals are at particular risk of development of atrial fibrillation. Renin-angiotensin-aldosteron system (RAS) which is activated in hypertension may be the underlying mechanism of AF among hypertensive patients. Vitamin D deficiency has been shown to be involved in the pathogenesis of hypertension, cardiovascular disease and obesity. Increased RAS activity is one of the postulated mechanisms by which vitamin D deficiency may trigger the development of hypertension and various cardiovascular diseases. On the basis of these data we hypothesized that hypovitaminosis D might be associated with new-onset AF among patients with hypertension.
Trial Health
Trial Health Score
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participants targeted
Target at P75+ for all trials
Started Jan 2012
Typical duration for all trials
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Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2014
CompletedFirst Submitted
Initial submission to the registry
November 20, 2014
CompletedFirst Posted
Study publicly available on registry
November 24, 2014
CompletedNovember 24, 2014
November 1, 2014
2.8 years
November 20, 2014
November 21, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
hypovitaminosis D
Identifying whether hypovitaminosis D is a risk factor for development of new-onset AF among hypertensive patients
Baseline
Study Arms (2)
New onset Atrial fibrillation
New-onset AF was defined as patients with hypertension and atrial fibrillation which was identified for the first time by an electrocardiogram or ambulatory holter monitoring.
control
Hypertensive patients without atrial fibrillation.
Eligibility Criteria
Hypertensive patients with new-onset AF. New onset AF was defined as AF identified for the first time by an electrocardiogram or ambulatory holter monitoring. Hypertension was defined as blood pressure ≥ 140/90 mmHg or a history of antihypertensive drug use.
You may qualify if:
- Hypertensive patients with new-onset AF
You may not qualify if:
- Established coronary artery disease
- Heart failure
- Chronic obstructive pulmonary disease
- Diabetes mellitus
- Significant heart valve disease
- Hyperthyroidism
- Renal failure
- Any malignancy
- Acute infection
- Recent thoracic or abdominal surgery
- Under therapy of Vit D3
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr Ozgur Ulas Ozcan
Study Record Dates
First Submitted
November 20, 2014
First Posted
November 24, 2014
Study Start
January 1, 2012
Primary Completion
November 1, 2014
Study Completion
November 1, 2014
Last Updated
November 24, 2014
Record last verified: 2014-11