An fMRI Study of Satiation in Healthy Volunteers.
Satiation Attenuates BOLD Activity in Brain Regions Involved in Reward and Increases Activity in an Inhibitory Control Area: an fMRI Study in Healthy Volunteers.
1 other identifier
interventional
16
1 country
1
Brief Summary
To our knowledge no study has assessed the effects of a meal on neural responses to food cues and compared this with a condition simulating natural inter-meal hunger levels. This is important, as the existing literature often compares the effect of fasting to satiation, which may not reflect typical appetite processes. Thus, the purpose of this research was to examine the effect of a satiating lunch compared to a normal pre-meal state on blood oxygen level dependent (BOLD) activity in the human brain, as measured using functional magnetic resonance imaging (fMRI).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jul 2010
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2010
CompletedFirst Submitted
Initial submission to the registry
November 19, 2014
CompletedFirst Posted
Study publicly available on registry
November 21, 2014
CompletedNovember 21, 2014
November 1, 2014
5 months
November 19, 2014
November 20, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Activation differences between satiated and pre-meal scan fMRI BOLD signal
6 months
Study Arms (1)
Scanning
OTHERRepeated measures: Satiation scan + Pre-meal scan All participants undertook both scans
Interventions
All participants were scanned before and after not being fed (pre-meal), and before and after being given a satiating lunch (satiated).
Eligibility Criteria
You may qualify if:
- Healthy volunteers
- Sufficiently fluent in English to understand the task and the instructions
You may not qualify if:
- Currently taking medication
- Past or current depression/dieting,
- Smokers
- Food allergies
- Diabetes
- Pregnancy
- BMI score outside the normal range
- Any contraindications to fMRI scanning (e.g. pacemakers, mechanical heart valve, hip replacement, metal implants)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Birminghamlead
- University of Oxfordcollaborator
Study Sites (1)
University of Birmingham
Birmingham, West Midlands, B15 2TT, United Kingdom
Related Publications (1)
Thomas JM, Higgs S, Dourish CT, Hansen PC, Harmer CJ, McCabe C. Satiation attenuates BOLD activity in brain regions involved in reward and increases activity in dorsolateral prefrontal cortex: an fMRI study in healthy volunteers. Am J Clin Nutr. 2015 Apr;101(4):697-704. doi: 10.3945/ajcn.114.097543. Epub 2015 Jan 21.
PMID: 25833968DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Jason M Thomas, MRes
University of Birmingham
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 19, 2014
First Posted
November 21, 2014
Study Start
July 1, 2010
Primary Completion
December 1, 2010
Study Completion
December 1, 2010
Last Updated
November 21, 2014
Record last verified: 2014-11