Comparison of DSM-IV-TR and DSM-5 for ASD

NCT02296502 | Completed Results

• 1 other identifier: DSM5 and ASD
• Study Type: observational
• Target: 439
• Locations: 1 country
• Sites: 5

Brief Summary

The study aim is to prospectively compare DSM-IV-TR and DSM-5 criteria for Autism Spectrum Disorder (ASD) in a sample of 250 children and adolescents who meet DSM-IV-TR criteria for ASD and 150 children and adolescents referred for diagnosis who do not meet DSM-IV-TR criteria.Families and children will be recruited from eight sites affiliated with the Autism Treatment Network (ATN). Participants must be between the ages of 2.0 and 17.11 years who undergo an ATN assessment at one of the eight sites. Both subjects who are found to meet criteria of ASD/PDD and those who do not meet criteria (after completing the ATN assessment) will be enrolled. After completing the standard ATN assessment, clinicians will complete a DSM-IV and DSM-5 checklist for ASD/PDD.

Conditions

Autism Spectrum Disorder

Keywords

DSM Diagnosis

Outcome Measures

Primary Outcomes (2)

• Clinical Features of Concordant vs Discordant Groups

  Clinical Features of Concordant versus Discordant Groups. Full Scale IQ: Stanford-Binet IQ test.(score range 40-160; higher = greater intellectual abilties) ABC = Aberrant Behavior Checklist, which includes: Irritability subscale: score range 0-45, higher = more problems. Social Withdrawal subscale: score range 0-48, higher = more problems. Stereotypic Behavior subscale: score range 0-21, higher = more problems. Hyperactivity/Noncompliance subscale: score range 0-48, higher = more problems. Inappropriate Speech subscale: score range 0-12, higher = more problems. CBCL = Child Behavior Checklist, which includes: Externalizing Problems and Internalizing problems: T scores less than 60 are considered in the normal range, 60-63 represent borderline scores, and scores greater than 63 are in the clinical range

  One day

• Sensitivity and Specificity of DSM-5 Criteria for ASD Relative to DSM-IV Criteria

  Sensitivity and Specificity of DSM-5 Criteria for ASD Relative to DSM-IV Criteria Sensitivity refers to the ability of the DSM-5 to correctly identify those with ASD, whereas specificity is the ability of the DSM-5 to correctly identify those without ASD.

  day

Study Arms (4)

Autism Spectrum Disorder (DSM IV & 5)

All children and adolescents seen for autism diagnostic evaluations at the study sites who meet diagnostic criteria for ASD in both DSM-IV and DSM-5

Other: DSM

Autism Spectrum Disorder (DSM 5 only)

All children and adolescents seen for autism diagnostic evaluations at the study sites who meet diagnostic criteria for ASD in DSM-5 but not DSM-IV

Other: DSM

Autism Spectrum Disorder (DSM IV only)

All children and adolescents seen for autism diagnostic evaluations at the study sites who meet diagnostic criteria for ASD in DSM-IV but not DSM-5

Other: DSM

Non-Autism Spectrum Disorder

All children and adolescents seen for autism diagnostic evaluations at the study sites who do not meet diagnostic criteria for ASD.

Other: DSM

Interventions

DSM OTHER

Comparing use of DSM-IV versus DSM-5 criteria for autism spectrum disorder

Autism Spectrum Disorder (DSM 5 only); Autism Spectrum Disorder (DSM IV & 5); Autism Spectrum Disorder (DSM IV only); Non-Autism Spectrum Disorder

Eligibility Criteria

• Age: 2 Years - 17 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

All children ages 2-17 who are being evaluated for a possible diagnosis of autism spectrum disorder

You may qualify if:

• age 2-17
• question of possible autism spectrum disorder

You may not qualify if:

• \<2 years old \>17 years old

Sponsors & Collaborators

• University of Pittsburgh: lead
• University of Missouri-Columbia: collaborator
• Children's Hospital Los Angeles: collaborator
• Nationwide Children's Hospital: collaborator
• Children's Hospital Medical Center, Cincinnati: collaborator
• Vanderbilt University: collaborator

Study Sites (5)

Children's Hospital of Los Angeles

Los Angeles, California, 90027, United States

Location

University of Missouri

Columbia, Missouri, 65201, United States

Location

Children's Hospital of Cincinnati

Cincinnati, Ohio, 45229, United States

Location

Nationwide Children's Hospital

Columbus, Ohio, 43081, United States

Location

Vanderbilt University

Nashville, Tennessee, 37240, United States

Location

MeSH Terms

Conditions

Autism Spectrum Disorder

Condition Hierarchy (Ancestors)

Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders

Results Point of Contact

• Title: Benjamin L Handen, PhD
• Organization: University of Pittsburgh

handenbl@upmc.edu

412-235-5445

Study Officials

• Benjamin Handen, PhD

  University of Pittsburgh

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professof of Psychiatry

Study Record Dates

• First Submitted: November 18, 2014
• First Posted: November 20, 2014
• Study Start: November 1, 2014
• Primary Completion: November 1, 2016
• Study Completion: November 1, 2016
• Last Updated: March 11, 2019
• Results First Posted: March 11, 2019

Record last verified: 2018-11

Locations

US (5)