Dietary Intakes and Periodontal Outcomes After Sanative Therapy

NCT02291835 | Completed

• 1 other identifier: BrockU
• Study Type: observational
• Target: 129
• Locations: 0 countries
• Sites: N/A

Brief Summary

Periodontitis is a chronic inflammatory disease and a significant risk factor for tooth loss. While a link between diet and periodontal health exists, the relationship between diet and healing following periodontal therapy has yet to be investigated.The objective of this study was to determine if higher intakes of foods and nutrients with antioxidant or anti-inflammatory activity are associated with reduced probing depth following sanative therapy. Sanative therapy is a first line cost-effective treatment to manage periodontal disease and thus prevent tooth loss. Patients with chronic generalized periodontitis undergoing sanative therapy were recruited for the study. Mean probing depth was assessed at baseline and 8-16 weeks following sanative therapy. Dietary intakes of fruits, vegetables, vitamins and dietary fats were estimated using the Block 2005 food frequency questionnaire and supplement use was recorded using a questionnaire. A small venous blood sample was also collected at baseline to measure serum 25-hydroxyvitamin D concentrations.

Conditions

Periodontal Pocket

Outcome Measures

Primary Outcomes (1)

• Periodontal healing evaluated based on changes in mean probing depth

  Healing is evaluated based on changes in mean probing depth

  Baseline and between 8 and 16 weeks after sanative therapy

Other Outcomes (3)

• Dietary nutrient intakes

  Completed by participant anytime between study enrolment and follow-up (8 to 16 weeks after sanative therapy)

• Supplemental nutrient intakes

  Completed by participant anytime between study enrolment and follow-up (8 to 16 weeks after sanative therapy)

• Serum 25-hydroxyvitamin D concentrations

  Sample collected at baseline visit when sanative therapy was performed

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients undergoing sanative therapy for the treatment of chronic generalized periodontitis.

You may qualify if:

• All adult patients undergoing sanative therapy were eligible.

You may not qualify if:

• under 19 years of age

Sponsors & Collaborators

• Brock University: lead

Related Publications (1)

• Dodington DW, Fritz PC, Sullivan PJ, Ward WE. Higher Intakes of Fruits and Vegetables, beta-Carotene, Vitamin C, alpha-Tocopherol, EPA, and DHA Are Positively Associated with Periodontal Healing after Nonsurgical Periodontal Therapy in Nonsmokers but Not in Smokers. J Nutr. 2015 Nov;145(11):2512-9. doi: 10.3945/jn.115.211524. Epub 2015 Sep 30.

  PMID: 26423734 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum

MeSH Terms

Conditions

Periodontal Pocket

Condition Hierarchy (Ancestors)

Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Wendy E Ward, PhD

  Professor

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor and Canada Research Chair in Bone and Muscle Development

Study Record Dates

• First Submitted: October 16, 2014
• First Posted: November 17, 2014
• Study Start: January 1, 2013
• Primary Completion: August 1, 2014
• Study Completion: August 1, 2014
• Last Updated: August 28, 2018

Record last verified: 2018-08