NCT02290756

Brief Summary

The investigators propose to develop and test the efficacy of a low cost evidence based toolkit aimed at improving brain development among newborns a rural setting of Pakistan. The toolkit will include a safe delivery kit, nutritional supplementation, and trainings on cord care, hypothermia management, aspiration and bag and mask techniques and APGAR score calculation. A simple, home-based parenting program will also be implemented that will teach parents tools that provide stimuli for brain and cognitive development in children. This parenting program covers Early Childhood Interventions for children at risk of developmental problems and covers developmental skill areas such as cognitive and fine motor, social and self-help and gross motor skills. Such an intervention package provides comprehensive care to families at the community level, with a minimal cost that can be scaled up. A new cadre of Link workers will be implemented who will provide mentoring and supportive supervision to Birth Attendants and will train parents in the stimulation program. The study will recruit 1080 pregnant women and their newborns.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
1,080

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jan 2015

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 21, 2014

Completed
24 days until next milestone

First Posted

Study publicly available on registry

November 14, 2014

Completed
2 months until next milestone

Study Start

First participant enrolled

January 1, 2015

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2016

Completed
Last Updated

December 2, 2015

Status Verified

November 1, 2015

Enrollment Period

1.7 years

First QC Date

October 21, 2014

Last Update Submit

November 30, 2015

Conditions

Keywords

Early child developmentLink WorkersCommunity Birth attendantsParenting Program

Outcome Measures

Primary Outcomes (1)

  • Improvement in Bayleys Scale for Infant Development score

    one time assessment at infant's 12 month birthday

Secondary Outcomes (2)

  • HOME inventory test

    2 assessments at 6 months birthday and 12 month birthday of the infant

  • Parent-Child Interaction assessment

    2 assessments at 6 months birthday and 12 month birthday of the infant

Study Arms (2)

Parenting program and toolkit

ACTIVE COMPARATOR

The intervention arm of the study will have the low cost evidence based toolkit delivered to the the pregnant women for the duration of their pregnancy and the parenting program delivered to the newborn for 12 months.

Behavioral: Parenting ProgramBehavioral: Low cost evidence based toolkit

Control- toolkit

OTHER

The control arm of the study will only have the low cost evidence based toolkit delivered to the the pregnant women for the duration of their pregnancy.

Behavioral: Low cost evidence based toolkit

Interventions

The parenting program is an early childhood stimulation program aimed at newborns from their neonatal period till infancy. The implementation of the parenting program will be conducted through the link workers and parents of the newborns.

Parenting program and toolkit

The aim of providing the toolkit is to ensure that all pregnant women in the project are provided the requisite care needed from the antenatal period till delivery to limit complications and insults (both mother and especially the neonate) that can occur during pregnancy, delivery and post partum in both the mother and child. The contents of the toolkit will include: 1. Clean delivery kit, aspiration bulb, bag and mask, Chlorhexidine, Misoprostol, Nutritional supplements (Iron and folic acid, awareness about breastfeeding) and IEC materials 2. Trainings for Birth Attendants and Link workers on aspiration and hypothermia management techniques, use of bag and mask APGAR (also to parents), cord care, basic pregnancy and newborn care information

Control- toolkitParenting program and toolkit

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Those pregnant women who are starting the second trimester of their pregnancy;
  • Those women who will continue to live in the community/village during the pregnancy period and until one year postpartum.

You may not qualify if:

  • Those pregnant women who appear to be, in the link worker's judgment, incapable of understanding the information provided about the study (e.g., mentally incapacitated, cognitively impaired etc.)
  • Not willing to participate in the study/unwilling to provide informed consent or the consent of their family.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Center for Global Public Health

Islamabad, 44000, Pakistan

RECRUITING

Study Officials

  • James F Blanchard, MSc

    University of Manitoba

    PRINCIPAL INVESTIGATOR
  • Tahira E Reza, MSc

    Centre for Global Public Health Pakistan

    PRINCIPAL INVESTIGATOR

Central Study Contacts

James F Blanchard, MSc

CONTACT

Momina Salim, MPH

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Center Director

Study Record Dates

First Submitted

October 21, 2014

First Posted

November 14, 2014

Study Start

January 1, 2015

Primary Completion

September 1, 2016

Study Completion

September 1, 2016

Last Updated

December 2, 2015

Record last verified: 2015-11

Locations