Effects of NAVA and PSV to AECOPD Patients' Air Distribution and Dead Space
1 other identifier
interventional
15
0 countries
N/A
Brief Summary
Chronic obstructive pulmonary disease(COPD) is a common disease among people. Acute exacerbation of chronic obstructive pulmonary disease(AECOPD) is the acute and aggravating phase of COPD which may lead to respiratory failure. Mechanical ventilation is a very important therapy for those patients,but traditional ventilation modes have some defects, so investigators need to find new modes to solve these problems. In this study, the investigators compare neurally adjusted ventilatory assist (NAVA) and PSV to observe the effects on AECOPD patients' air distribution and dead space to determine if NAVA is a more appropriate ventilation mode for AECOPD patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_3 chronic-obstructive-pulmonary-disease
Started Nov 2014
Shorter than P25 for phase_3 chronic-obstructive-pulmonary-disease
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 16, 2014
CompletedStudy Start
First participant enrolled
November 1, 2014
CompletedFirst Posted
Study publicly available on registry
November 13, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2015
CompletedNovember 13, 2014
October 1, 2014
7 months
October 16, 2014
November 12, 2014
Conditions
Outcome Measures
Primary Outcomes (1)
the ratio of physiologic dead space over tidal volume (VD/VT)
1 year
Study Arms (2)
neurally adjusted ventilatory assist
EXPERIMENTALpressure support ventilation
SHAM COMPARATORInterventions
change ventilation modes(NAVA and PSV) with different support levels
Eligibility Criteria
You may qualify if:
- AECOPD patients who need invasive mechanical ventilation
- Patients who can tolerate assist mechanical ventilation
- Patients who have signed ICF
You may not qualify if:
- Patients who are younger than 18 years old or older than 75 years old
- Patients whose respiratory center is severely inhibited
- Patients who can not stand NAVA gastric tube
- Patients who have coagulation disorders
- Patients whose vital signs are unstable
- Patients who are in other clinical trails
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Sun Q, Liu L, Pan C, Zhao Z, Xu J, Liu A, Qiu H. Effects of neurally adjusted ventilatory assist on air distribution and dead space in patients with acute exacerbation of chronic obstructive pulmonary disease. Crit Care. 2017 Jun 2;21(1):126. doi: 10.1186/s13054-017-1714-1.
PMID: 28578708DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD
Study Record Dates
First Submitted
October 16, 2014
First Posted
November 13, 2014
Study Start
November 1, 2014
Primary Completion
June 1, 2015
Study Completion
June 1, 2015
Last Updated
November 13, 2014
Record last verified: 2014-10