NCT02282748

Brief Summary

The planned research project is a prospective population-based cohort study, similar to the well-known Framingham study in the United States. So far, there is no similar research project in Switzerland. It is planned to examine of three Swiss municipalities. Recruitment in a first Swiss municipality (Lostallo/Cama GR) started 2014 and ended in 2019. Overall, 496 participants were recruited in this municipality. The five-year follow-up in this municipality started in 2019. It is planned to start recruitment in a second Swiss municipality (Uznach SG) in 2020. The examinations embrace a broad spectrum of measurements (for details the investigators refer to the published study protocol).

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,000

participants targeted

Target at P75+ for all trials

Timeline
102mo left

Started Oct 2014

Longer than P75 for all trials

Geographic Reach
1 country

3 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress58%
Oct 2014Sep 2034

Study Start

First participant enrolled

October 1, 2014

Completed
28 days until next milestone

First Submitted

Initial submission to the registry

October 29, 2014

Completed
6 days until next milestone

First Posted

Study publicly available on registry

November 4, 2014

Completed
9.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2024

Completed
10 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2034

Expected
Last Updated

February 18, 2020

Status Verified

February 1, 2020

Enrollment Period

9.9 years

First QC Date

October 29, 2014

Last Update Submit

February 14, 2020

Conditions

Cardiovascular Risk Factors

Outcome Measures

Primary Outcomes (1)

  • Mortality

    10 years

Secondary Outcomes (6)

  • Cardiovascular events

    10 years

  • Heart function

    10 years

  • Cognitive function

    10 years

  • Kidney function

    10 years

  • Autonomy

    10 years

  • +1 more secondary outcomes

Other Outcomes (1)

  • Changes in cardiovascular risk factors

    10 years

Interventions

No interventionOTHER

Eligibility Criteria

Age6 Years+
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Population of four Swiss municipalities

You may qualify if:

  • Resident of Cama GR, Lostallo GR, or Uznach SG
  • Age ≥6 years (no upper age limit), for voluntary blood sample ≥18 years
  • Willing to participate in long-term study
  • Written informed consent (in participants ≥6 years and \<18 years signed by parents)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Linth Hospital

Uznach, Canton of St. Gallen, 8730, Switzerland

RECRUITING

Cama

Cama, Kanton Graubünden, CH-6557, Switzerland

RECRUITING

Lostallo

Lostallo, Kanton Graubünden, CH-6558, Switzerland

RECRUITING

Related Publications (3)

  • Pusterla L, Radovanovic D, Muggli F, Erne P, Schoenenberger AW, Schoenenberger-Berzins R, Parati G, Suter P, Lava SAG, Gallino A, Bianchetti MG. Impact of Cardiovascular Risk Factors on Arterial Stiffness in a Countryside Area of Switzerland: Insights from the Swiss Longitudinal Cohort Study. Cardiol Ther. 2022 Dec;11(4):545-557. doi: 10.1007/s40119-022-00280-8. Epub 2022 Sep 24.

    PMID: 36152116DERIVED

  • Schoenenberger AW, Radovanovic D, Muggli F, Suter PM, Schoenenberger-Berzins R, Parati G, Bianchetti MG, Gallino A, Erne P. Prevalence of ideal cardiovascular health in a community-based population - results from the Swiss Longitudinal Cohort Study (SWICOS). Swiss Med Wkly. 2021 Sep 28;151:w30040. doi: 10.4414/smw.2021.w30040. eCollection 2021 Sep 27.

    PMID: 34581550DERIVED

  • Schoenenberger AW, Muggli F, Parati G, Gallino A, Ehret G, Suter PM, Schoenenberger-Berzins R, Resink TJ, Erne P. Protocol of the Swiss Longitudinal Cohort Study (SWICOS) in rural Switzerland. BMJ Open. 2016 Nov 28;6(11):e013280. doi: 10.1136/bmjopen-2016-013280.

    PMID: 27895066DERIVED

Study Officials

  • Paul Erne, MD

    Hypertension Excellence Centre Lucerne

    STUDY CHAIR

  • Andreas W Schoenenberger, MD

    University Department of Geriatrics, University of Bern

    PRINCIPAL INVESTIGATOR

  • Paolo Suter, MD

    University of Zurich

    PRINCIPAL INVESTIGATOR

  • Franco Muggli, MD

    Swiss Society of Hypertension

    PRINCIPAL INVESTIGATOR

  • Renate Schoenenberger, MD

    Hypertension Excellence Centre Lucerne

    PRINCIPAL INVESTIGATOR

  • Pierre-Alexandre Krayenbühl, MD

    Linth Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Paul Erne, MD

CONTACT

paul.erne@erne-net.ch

Andreas W Schoenenberger, MD

CONTACT

Andreas.Schoenenberger@insel.ch

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 29, 2014

First Posted

November 4, 2014

Study Start

October 1, 2014

Primary Completion

September 1, 2024

Study Completion (Estimated)

September 1, 2034

Last Updated

February 18, 2020

Record last verified: 2020-02

Locations

CH(3)