NCT02271685

Brief Summary

Participants will be assigned to complete computerized estimation tasks for which there is a component of accuracy, such as estimating the duration of sounds. Participants will be told that the task is used as an early diagnostic tool to detect those at risk for a medical condition (e.g., Parkinson's disease, Alzheimer's disease). Instructions will be given to participants telling them that accuracy on the task is associated with the disease, whereas those who are not at risk of the disease tend to either overestimate or underestimate the duration of the sounds. The investigators examine whether such instructions about the purpose and diagnosticity of the tasks biases participants' responses to the tasks, leading them to purposefully be more inaccurate in their estimates.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
600

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Feb 2015

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 20, 2014

Completed
2 days until next milestone

First Posted

Study publicly available on registry

October 22, 2014

Completed
3 months until next milestone

Study Start

First participant enrolled

February 1, 2015

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2015

Completed
Last Updated

May 21, 2015

Status Verified

May 1, 2015

Enrollment Period

3 months

First QC Date

October 20, 2014

Last Update Submit

May 19, 2015

Conditions

Parkinson'sAlzheimer Disease

Keywords

Diagnostic InformationRisk Perception

Outcome Measures

Primary Outcomes (1)

  • Time Estimate

    The estimate of the length of time elapsed during the sound file

    30 minutes

Secondary Outcomes (2)

  • Time Generation

    30 minutes

  • Perceived Risk of Disease

    30 minutes

Study Arms (4)

Overestimate Parkinson's

EXPERIMENTAL

People are told that overestimates on the sound estimation task are associated with being healthy and having a low risk of Parkinson's disease, whereas those who are accurate are more likely to develop the disease later in life.

Other: Instructions about OverestimatesOther: Instructions about Parkinson's

Overestimate Alzheimers

EXPERIMENTAL

People are told that overestimates on the sound estimation task are associated with being healthy and having a low risk of Alzheimers disease, whereas those who are accurate are more likely to develop the disease later in life.

Other: Instructions about OverestimatesOther: Instructions about Alzheimers

Underestimate Parkinson's

EXPERIMENTAL

People are told that underestimates on the sound estimation task are associated with being healthy and having a low risk of Parkinson's disease, whereas those who are accurate are more likely to develop the disease later in life.

Other: Instructions about Parkinson'sOther: Instructions about Underestimates

Underestimate Alzheimers

EXPERIMENTAL

People are told that underestimates on the sound estimation task are associated with being healthy and having a low risk of Alzheimers disease, whereas those who are accurate are more likely to develop the disease later in life.

Other: Instructions about UnderestimatesOther: Instructions about Alzheimers

Interventions

Instructions about OverestimatesOTHER

Participants are told that overestimating the duration of sounds are associated with low disease risk.

Overestimate AlzheimersOverestimate Parkinson's
Instructions about Parkinson'sOTHER

Participants are told that the task is about risk of Parkinson's disease.

Overestimate Parkinson'sUnderestimate Parkinson's
Instructions about UnderestimatesOTHER

Participants are told that underestimating the duration of sounds are associated with low disease risk.

Underestimate AlzheimersUnderestimate Parkinson's
Instructions about AlzheimersOTHER

Participants are told that the task is about risk of Alzheimers disease.

Overestimate AlzheimersUnderestimate Alzheimers

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • or older
  • Able to access tasks on computer
  • Able to hear sounds played on computer

You may not qualify if:

  • Computer speakers absent or not functioning

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Carnegie Mellon University

Pittsburgh, Pennsylvania, 15213, United States

Location

MeSH Terms

Conditions

Parkinson DiseaseAlzheimer Disease

Condition Hierarchy (Ancestors)

Parkinsonian DisordersBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMovement DisordersSynucleinopathiesNeurodegenerative DiseasesDementiaTauopathiesNeurocognitive DisordersMental Disorders

Study Officials

  • Eric M VanEpps, MS

    Carnegie Mellon University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
SCREENING
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
PhD Candidate

Study Record Dates

First Submitted

October 20, 2014

First Posted

October 22, 2014

Study Start

February 1, 2015

Primary Completion

May 1, 2015

Study Completion

May 1, 2015

Last Updated

May 21, 2015

Record last verified: 2015-05

Locations

US(1)